• How Does Cigarette Smoking Lead to Chronic Pancreatitis?

How Does Cigarette Smoking Lead to Chronic Pancreatitis?

Aryl hydrocarbons in cigarette smoke activate an immune response that promotes pancreatic fibrosis and contributes to pancreatitis, researchers report in the December issue of Gastroenterology. The authors show that constituents of tobacco smoke activate signaling via the aryl hydrocarbon receptor (AHR) to induce T-cell production of interleukin 22 (IL22), activating

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  • Do Relatives of Patients With IBD Also Have Intestinal Dysbiosis?

Do Relatives of Patients With IBD Also Have Intestinal Dysbiosis?

The intestinal microbiota of many healthy, first-degree relatives of patients with inflammatory bowel diseases (IBD) is dysbiotic, signifying a pre-disease state, low-level inflammation, and susceptibility to IBD, researchers report in the November issue of Cellular and Molecular Gastroenterology and Hepatology. Changes in the intestinal microbiome are involved in the pathogenesis

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  • Can Yoga Reduce Symptoms of IBS?

Can Yoga Reduce Symptoms of IBS?

Yoga might be a feasible and safe adjunct treatment for irritable bowel syndrome (IBS), a systematic review shows in the December issue of Clinical Gastroenterology and Hepatology. The review found evidence for beneficial effects of yoga on gastrointestinal (GI) symptoms, quality of life, and anxiety, although further studies are needed. IBS is

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  • How Does Inflammation Lead to Anemia?

How Does Inflammation Lead to Anemia?

Researchers report a mechanism by which inflammation contributes to development of anemia in the November issue of Gastroenterology. The process involves increased liver expression of a microRNA that reduces production of erythropoietin in kidney. Strategies to block this miRNA might help prevent anemia in patients with chronic inflammation. Anemia is associated

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  • Can Histologic Features Identify Patients with GERD?

Can Histologic Features Identify Patients with GERD?

Total epithelial thickness is a robust histologic marker that can be used in detection of gastroesophageal reflux disease (GERD), researchers report in the November issue of Clinical Gastroenterology and Hepatology. GERD can be a challenge to diagnose because its symptoms overlap with those of other disorders. Endoscopy and esophageal pH

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  • Why do Pancreatic Tumor Cells Love the Liver?

Why do Pancreatic Tumor Cells Love the Liver?

Pancreatic ductal adenocarcinoma (PDAC) and its precursors secrete high levels of tissue inhibitor of metalloproteinases 1 (TIMP1) into the circulation, which activates hepatic stellate cells (HSCs) in liver. These cells help create a niche that promotes metastasis of pancreatic tumors to liver, researchers report in the November issue of Gastroenterology.

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  • Can Direct-acting Antivirals Treatment of HCV Reactivate Herpesvirus Infection?

Can Direct-acting Antivirals Treatment of HCV Reactivate Herpesvirus Infection?

Researchers report reactivation of herpesvirus in 10 patients with hepatitis C virus (HCV) infection treated with direct-acting antiviral (DAA) agents in the November issue of Clincial Gastroenterology and Hepatology. Christie Perelló et al performed a case series analysis of reactivation of herpesvirus in patients with HCV infection treated with DAA

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  • How Could the Intestinal Microbiota Contribute to Celiac Disease?

How Could the Intestinal Microbiota Contribute to Celiac Disease?

Bacteria in the small intestine metabolize gluten differently, to increase or decrease its immunogenicity, researchers report in the October issue of Gastroenterology. This interaction between microbes and gluten could help determine the risk for autoimmune enteropathy in genetically susceptible individuals and underlie the reported association between dysbiosis and celiac disease.

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  • Candy Cane Esophagus From Hot Tea

Candy Cane Esophagus From Hot Tea

Researchers describe a patient with a “candy cane appearance” of the esophagus, due to acute thermal injury, in the October issue of Clinical Gastroenterology and Hepatology. Upon further investigation, the authors found that the patient had poured hot boiling tea into his throat. Arun AC and Jenish Rajma describe the case of a 19-year-old

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  • Can Disruption of the Intestinal Epithelial Barrier Contribute to Steatohepatitis?

Can Disruption of the Intestinal Epithelial Barrier Contribute to Steatohepatitis?

Mice with defects in intestinal epithelial permeability develop more severe steatohepatitis when placed on a diet high in saturated fat, fructose, and cholesterol (HFCD) than control mice, and colon tissues from patients with non-alcoholic fatty liver disease (NAFLD) have similar defects in intestinal epithelial permeability, researchers report in the October

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  • What is the Best Way to Predict Disease Progression in Patients With Inactive HBV?

What is the Best Way to Predict Disease Progression in Patients With Inactive HBV?

In patients with chronic hepatitis B virus (HBV) infection who are negative for HBe antigen (HBeAg), monitoring levels of HB surface antigen (HBsAg) can predict disease progression, researchers report in the October issue of Clinical Gastroenterology and Hepatology. Most persons chronically infected with HBV clear HBeAg and enter an inactive carrier phase, characterized by low or undetectable

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  • Time for Peer Review Week!

Time for Peer Review Week!

September 19th to 25th is Peer Review Week! Peer Review Week is a global event celebrating the essential role that peer review has in maintaining scientific quality. The goal is to bring together individuals, institutions, and organizations committed to sharing the central message that good peer review, whatever shape or form it

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  • CMGH now Searchable in PubMed!

CMGH now Searchable in PubMed!

Cellular and Molecular Gastroenterology and Hepatology (CMGH), published by the American Gastroenterological Association, has been accepted for indexing in PubMed Central, which will make all CMGH articles, starting with Volume 1, Issue 1, searchable as full text in PubMed over the next several weeks. In an editorial written for the September

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  • Does Pancreatectomy With Islet Autotransplantation Benefit Patients With Recurrent Acute Pancreatitis?

Does Pancreatectomy With Islet Autotransplantation Benefit Patients With Recurrent Acute Pancreatitis?

In patients with recurrent acute pancreatitis, total pancreatectomy with islet autotransplantation (TPIAT) reduces pain and requirements for narcotic therapy, and increases quality of life, researchers report in the September issue of Clinical Gastroenterology and Hepatology. This treatment should be considered when medical and endoscopic therapies have failed. Recurrent acute pancreatitis, caused

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