• Time for Peer Review Week!

Time for Peer Review Week!

September 19th to 25th is Peer Review Week! Peer Review Week is a global event celebrating the essential role that peer review has in maintaining scientific quality. The goal is to bring together individuals, institutions, and organizations committed to sharing the central message that good peer review, whatever shape or form it

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  • CMGH now Searchable in PubMed!

CMGH now Searchable in PubMed!

Cellular and Molecular Gastroenterology and Hepatology (CMGH), published by the American Gastroenterological Association, has been accepted for indexing in PubMed Central, which will make all CMGH articles, starting with Volume 1, Issue 1, searchable as full text in PubMed over the next several weeks. In an editorial written for the September

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  • Does Pancreatectomy With Islet Autotransplantation Benefit Patients With Recurrent Acute Pancreatitis?

Does Pancreatectomy With Islet Autotransplantation Benefit Patients With Recurrent Acute Pancreatitis?

In patients with recurrent acute pancreatitis, total pancreatectomy with islet autotransplantation (TPIAT) reduces pain and requirements for narcotic therapy, and increases quality of life, researchers report in the September issue of Clinical Gastroenterology and Hepatology. This treatment should be considered when medical and endoscopic therapies have failed. Recurrent acute pancreatitis, caused

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  • A Forward Genetic Screen Identifies Suppressors of Hepatocellular Carcinogenesis

A Forward Genetic Screen Identifies Suppressors of Hepatocellular Carcinogenesis

Using 2 powerful high-throughput in vivo screening tools, researchers identified and validated 27 genes as suppressors of hepatocellular carcinoma (HCC), reported in the August issue of Gastroenterology. Their findings support the role of Ras signaling in development of HCC and provide new therapeutic targets. Sorafenib is the only treatment for patients

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  • Is Dietary Fiber OK for Patients With Crohn’s Disease or Ulcerative Colitis?

Is Dietary Fiber OK for Patients With Crohn’s Disease or Ulcerative Colitis?

Intake of dietary fiber reduces risk of disease flares in patients with Crohn’s disease, but not ulcerative colitis, researchers report in the August issue of Clinical Gastroenterology and Hepatology. Recommendations to limit dietary fiber should therefore be re-evaluated. Inflammatory bowel diseases (IBD) have been associated with an abnormal mucosal immune response to

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  • Video Abstract: Pros and Cons of Continued Aspirin Use in Patients with Lower GI Bleeding

Video Abstract: Pros and Cons of Continued Aspirin Use in Patients with Lower GI Bleeding

In aspirin users with a history of lower gastrointestinal bleeding, continued aspirin use increases risk of recurrent bleeding by almost 3-fold, but reduces risk of serious cardiovascular events by 40% and risk of death from other causes by 17%, researchers report in the August issue of Gastroenterology. First author Francis K.L. Chan discusses the group’s

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  • A Mouse Model for Studying Pancreatic Tumor Resection and Adjuvant Therapy

A Mouse Model for Studying Pancreatic Tumor Resection and Adjuvant Therapy

Researchers have developed mice that develop focal, resectable pancreatic tumors closely resembling human pancreatic ductal adenocarcinomas (PDACs) that can be used to test adjuvant therapies, according to new research in the August issue of Gastroenterology. The authors show that administration of gemcitabine after resection of the tumors activates natural killer (NK) cell-mediated

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  • Can Microbial Dysbiosis Cause Colonic Inflammation?

Can Microbial Dysbiosis Cause Colonic Inflammation?

Dysbiosis contributes to the pathogenesis of inflammatory bowel diseases (IBD) by altering colonic expression of genes that regulate inflammation and the immune response, researchers report in the July issue of Cellular and Molecular Gastroenterology and Hepatology. An altered intestinal microbiota composition has been associated with IBD. However, it is not

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  • Do Nonselective Beta Blockers Increase Mortality in Patients With Cirrhosis and Ascites?

Do Nonselective Beta Blockers Increase Mortality in Patients With Cirrhosis and Ascites?

Nonselective beta blockers (NSBBs) do not significantly increase the risk of death in patients with cirrhosis and ascites or refractory ascites, researchers report in the August issue of Clinical Gastroenterology and Hepatology. The findings from this meta-analysis do not support the position that NSBBs be routinely withheld from patients with

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What Happens to Infants Whose Mothers Took Anti-TNF Agents During Pregnancy?

Anti-tumor necrosis factor (TNF) agents can be detected in infants born to mothers with inflammatory bowel diseases (IBD) who took the drugs during pregnancy, researchers report in the July issue of Gastroenterology. Infliximab is cleared more slowly than adalimumab from infants. However, measureable levels in infants do not seem to be

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Pyoderma Gangrenosum in Fingers of Patient With Crohn’s Disease

In the July issue of Clinical Gastroenterology and Hepatology, researchers describe a patient with Crohn’s disease who developed pyoderma gangrenosum in an unusual location. Faisal Inayat and Abu Hurairah describe a 40-year-old woman who came into the hospital with bilateral, mild, localized pain and discoloration of the fingernails for 10 days (see picture).

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  • Long-term Efficacy of Octreotide in Patients with Polycystic Kidney and Liver Disease

Long-term Efficacy of Octreotide in Patients with Polycystic Kidney and Liver Disease

Three years of long-acting release octreotide (octreotide LAR) significantly reduced liver volume in patients with polycystic kidney and liver disease, researchers found in a placebo-controlled study. These reductions, reported in the July issue of Clinical Gastroenterology and Hepatology, were maintained for 2 years after treatment ended. Polycystic liver disease (PLD)

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  • How Much Do Antibiotics Increase Risk of Obesity in Young Children?

How Much Do Antibiotics Increase Risk of Obesity in Young Children?

Administration of 3 or more courses of antibiotics to children younger than 2 years greatly increases their risk for early childhood obesity, researchers report in the July issue of Gastroenterology. Antibiotics have been used to promote weight gain in the agricultural industry for decades. This effect is believed to be

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  • What is the Most Effective Method for Treating Unresectable Malignant Distal Biliary Obstruction?

What is the Most Effective Method for Treating Unresectable Malignant Distal Biliary Obstruction?

Endoscopic ultrasound-guided biliary drainage (EUS-BD) and percutaneous transhepatic biliary drainage (PTBD) are equally effective in treating patients with unresectable malignant distal biliary obstruction and inaccessible papilla, researchers report in the July issue of Clinical Gastroenterology and Hepatology. However, EUS-BD produced fewer procedure-related adverse events and unscheduled re-interventions. PTBD has been

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