• Can a Diet Low in FODMAPs Reduce IBS Symptoms in the Real World?

Can a Diet Low in FODMAPs Reduce IBS Symptoms in the Real World?

In patients with irritable bowel syndrome (IBS), a real-world diet low in fermentable oligosaccharides, monosaccharides, disaccharides and polyols (FODMAPs) reduced symptoms compared with a sham diet, researchers report in the October issue of Gastroenterology. The study also showed that co-administration of the multistrain probiotic increased numbers of Bifidobacterium species and might be

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  • Special 15th Anniversary Collection from CGH

Special 15th Anniversary Collection from CGH

Clinical Gastroenterology and Hepatology (CGH) proudly presents a special collection to celebrate the journal’s 15th year of publication. This collection comprises landmark articles chosen by the CGH Board of Editors for their contributions to science and the practice of gastroenterology and hepatology. The 15th anniversary collection includes commentaries from authors on select groundbreaking original research articles. In these, authors

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  • 3-D Imaging of T-cell Localization in Inflamed Colon Tissues

3-D Imaging of T-cell Localization in Inflamed Colon Tissues

Light sheet fluorescence microscopy (LSFM) provides accurate 3-dimensional images of inflammed intestine of mice with colitis, researchers show in a Gastroenterology in Motion article and video in the October issue of Gastroenterology. The authors demonstrate use of the technology to analyze migration of human T cells in colons of mice with colitis. Improved techniques are

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  • What is the Risk of Pancreatic Cancer in Patients with Low-Risk IPMNs?

What is the Risk of Pancreatic Cancer in Patients with Low-Risk IPMNs?

Low-risk intraductal papillary mucinous neoplasms have an almost 8% chance of progressing to pancreatic cancer within 10 years, whereas higher-risk IPMNs have almost 25% chance, reports a systematic review and meta-analysis in the October issue of Clinical Gastroenterology and Hepatology. Continued long-term surveillance is therefore important for patients with low-risk, as

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  • Can Restricting Fructose Intake Reduce Fatty Liver Disease in Children?

Can Restricting Fructose Intake Reduce Fatty Liver Disease in Children?

Reducing dietary fructose for as little as 9 days decreases liver fat, visceral fat, and de novo lipogenesis and increases insulin sensitivity, secretion, and clearance in children with obesity and metabolic syndrome, researchers report in the September issue of Gastroenterology. These findings support efforts to reduce sugar consumption. Consumption of sugar

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  • Could the Microbiota Link Metabolic Syndrome With Inflammation?

Could the Microbiota Link Metabolic Syndrome With Inflammation?

Bacterial encroachment—shrinking of the bug-free zone adjacent to the colonic epithelium—is a feature of metabolic syndrome, researchers report in the September issue of Cellular and Molecular Gastroenterology and Hepatology. The findings could explain the relationship between diabetes and inflammation. Mucoid structures that coat the epithelium keep the intestinal microbiota at

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  • Does Consumption of Certain Fatty Acids Increase Risk of Ulcerative Colitis Flares?

Does Consumption of Certain Fatty Acids Increase Risk of Ulcerative Colitis Flares?

Diets with high levels of fatty acids such as myristic acid (found in palm oil, coconut oil, and dairy fats) increased risk of flare in patients with ulcerative colitis (UC), researchers report in the September issue of Clinical Gastroenterology and Hepatology. Their findings, from a prospective study of more than 400 patients

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  • Can Exposure to Aflatoxin Cause Gallbladder Cancer?

Can Exposure to Aflatoxin Cause Gallbladder Cancer?

Exposure to aflatoxin increases risk of gallbladder cancer, researchers report in the September issue of Gastroenterology. Ingestion of aflatoxin, produced by a fungi that grows on corn and peanuts, could account for the high incidence of gallbladder cancers in some regions of China and Chile. Gallbladder cancer, the most common biliary tract cancer, has

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  • Does Asthma Increase Risk for Inflammatory Bowel Diseases?

Does Asthma Increase Risk for Inflammatory Bowel Diseases?

A population-based case–control study published in the September issue of Clinical Gastroenterology and Hepatology associates asthma with later development of Crohn’s disease (CD) and with ulcerative colitis (UC). Although the etiology of asthma and inflammatory bowel diseases (IBD) are not well understood, they both involve complex interactions among genetic and environmental factors and the

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  • What is the Best Management Strategy for Patients With NAFLD?

What is the Best Management Strategy for Patients With NAFLD?

Management of patients with non-alcoholic fatty liver disease (NAFLD) requires combined efforts of general practitioners, hepatologists, and other experts, Herbert Tilg explains in a Mentoring, Education, and Training Corner article in the August issue of Gastroenterology. NAFLD has become the most common liver disease worldwide. It ranges from simple steatosis in the absence

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  • Is Endoscopic Balloon Dilation Better Than Surgery for Patients With Crohn’s Disease-related Strictures?

Is Endoscopic Balloon Dilation Better Than Surgery for Patients With Crohn’s Disease-related Strictures?

In patients with Crohn’s disease (CD), surgical treatment of ileocolonic anastomosis strictures reduces risk of further surgery compared with endoscopic balloon dilation (EBD), researchers report in the August issue of Clinical Gastroenterology and Hepatology. However, endoscopic balloon dilation (EBD) delays time until need for a second surgery; EBD should be therefore attempted first

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  • Video: EUS Detection of Early-stage Gastric Cancer in a Patient with FAP

Video: EUS Detection of Early-stage Gastric Cancer in a Patient with FAP

Endoscopic ultrasound (EUS) can detect early-stage gastric cancers developing beneath or within the mucosa that are not visualized by endoscopy in patients with familial adenomatous polyposis (FAP). Researchers report these findings along with a video in the August issue of Gastroenterology. FAP is a hereditary colorectal cancer syndrome characterized by colorectal polyps and colorectal cancer. Patients

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  • Can THC Relieve Chronic Abdominal Pain?

Can THC Relieve Chronic Abdominal Pain?

In a phase 2 study, researchers found no difference between a delta-9-tetrahydrocannabinol (THC) tablet and a placebo tablet in reducing pain measures in patients with chronic abdominal pain from pancreatitis or surgery. Authors Marjan de Vries and Harry van Goor explain their findings in their video abstract: The study was

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  • What are the Complications of Proton Pump Inhibitor Therapy?

What are the Complications of Proton Pump Inhibitor Therapy?

A review article from Michael F. Vaezi et al discusses potential adverse consequences of proton-pump inhibitor (PPI) therapy in the July issue of Gastroenterology. Proton pump inhibitors (PPIs) are among the most commonly prescribed medicines for gastroesophageal reflux disease (GERD) and peptic ulcer disease. Multiple randomized controlled trials of PPIs have shown efficacy

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