• Are Eating Competitions Dangerous?

Are Eating Competitions Dangerous?

The stomachs of competitive eaters accommodate large quantities of food by repeated rapid distension of the gastric wall during eating episodes. A Clinical Challenges and Images in GI article in the June issue of Gastroenterology presents an adverse outcome of these competitions. Tian-Zhi Lim et al describe the case of a 30-year-old, healthy man

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  • Does Mucosal Inflammation Cause Diverticulosis?

Does Mucosal Inflammation Cause Diverticulosis?

Despite limited evidence that a chronic state of low-grade mucosal inflammation contributes to development of diverticulosis, a prospective study published in the June issue of Clinical Gastroenterology and Hepatology found no correlation of the disease with mucosal inflammation, upregulated immune markers, or gastrointestinal symptoms. Colonic diverticulosis (outpouchings from the colonic lumen) is

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Gastroenterology Special Issue on Endoscopy

A special issue of Gastroenterology, Advances in Endoscopic Therapy, presents the latest advances in gastrointestinal endoscopy, including endoscopic images and videos. In their introductory article, Jacques J. Bergman and Patrick S. Yachimski explain that endoscopy is central to gastroenterology clinical practice and research, allowing examination of healthy and diseased tissue from the organ level, to the

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  • What Changes Occur in the Esophageal Epithelial Barrier During Disease Development?

What Changes Occur in the Esophageal Epithelial Barrier During Disease Development?

A review article in the May issue of Clinical Gastroenterology and Hepatology discusses esophageal epithelial barrier structure and function, new and old techniques for studying this barrier, and changes that occur during development of esophageal diseases. To identify mechanisms of diseases associated with barrier dysfunction, such as gastroesophageal reflux disease (GERD), eosinophilic esophagitis,

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  • Does Acute Pancreatitis Increase Risk of Pancreatic Cancer?

Does Acute Pancreatitis Increase Risk of Pancreatic Cancer?

Patients hospitalized with acute pancreatitis have a 2-fold increased risk of pancreatic cancer compared with the general population, researchers report in the May issue of Gastroenterology. Acute pancreatitis is a sudden-onset inflammatory disease of the pancreas. Although acute pancreatitis promotes development of pancreatic cancer in mouse models, there have been conflicting findings from epidemiology

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  • What Are the Best Endpoints for Trials of Agents for Ulcerative Colitis?

What Are the Best Endpoints for Trials of Agents for Ulcerative Colitis?

Despite advances in methods of clinical trials for ulcerative colitis (UC), there is still a large amount of variation in endpoints, even in definitions of response and remission, reseachers found in a systematic review published in the May issue of Clinical Gastroenterology and Hepatology. The authors conclude that we need a

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A Parasitic Infection From Sashimi

Researchers report a case of anisakiasis, caused by nematodes of the genus Anisakis—a parasite transmitted to humans through raw seafood such as sushi and sashimi. In the May issue of Gastroenterology, Kaori Ikegami et al describe the case of a 47-year-old man who arrived at the emergency department with severe epigastric pain.

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  • What is the Best Way to Assess Treatment Response in Patients With Achalasia?

What is the Best Way to Assess Treatment Response in Patients With Achalasia?

A more accurate method to evaluate outcomes of treatment for achalasia is described in the May issue of Clinical Gastroenterology and Hepatology. The method identifies patients with good outcomes with higher levels of sensitivity (same specificity) than timed-barium esophagrams or impedance-manometry bolus transit assessments alone. Achalasia is an esophageal motor disorder

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  • What are the Challenges to In Vitro Maturation of Hepatic Stem Cells?

What are the Challenges to In Vitro Maturation of Hepatic Stem Cells?

New approaches are needed to generate and maintain stable and mature adult liver cells ex vivo. In the April issue of Gastroenterology, Bart Spee and colleagues review factors that promote hepatocyte differentiation and maturation, and consider criteria for establishing whether cells derived from stem cells are fully mature hepatocytes. They discuss challenges to cell transplantation and

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  • Does Pioglitazone Have the Same Effects on NASH in Patients With vs Without Diabetes?

Does Pioglitazone Have the Same Effects on NASH in Patients With vs Without Diabetes?

Patients with prediabetes and nonalcoholic steatohepatitis (NASH) benefit nearly as much from pioglitazone therapy as those with type-2 diabetes, researchers report in the April issue of Clinical Gastroenterology and Hepatology. The diabetes drug reduced fibrosis in non-diabetic patients with NASH, the clinical study found, although to a lesser extent than in patients

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