Cancer
  • Does Acute Pancreatitis Increase Risk of Pancreatic Cancer?

Does Acute Pancreatitis Increase Risk of Pancreatic Cancer?

Patients hospitalized with acute pancreatitis have a 2-fold increased risk of pancreatic cancer compared with the general population, researchers report in the May issue of Gastroenterology. Acute pancreatitis is a sudden-onset inflammatory disease of the pancreas. Although acute pancreatitis promotes development of pancreatic cancer in mouse models, there have been conflicting findings from epidemiology

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  • Does Drinking Coffee Increase Survival of Patients With Colorectal Cancer?

Does Drinking Coffee Increase Survival of Patients With Colorectal Cancer?

Drinking 2 or more cups of coffee per day after a diagnosis of stage I to III colorectal cancer (CRC) reduces risk of CRC-specific and all-cause mortality, researchers report in the March issue of Gastroenterology. Patients who maintain a high level of coffee consumption before and after diagnosis have even better odds for survival.

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  • Surgical vs Endoscopic Treatment of T1 Esophageal Adenocarcinoma?

Surgical vs Endoscopic Treatment of T1 Esophageal Adenocarcinoma?

Endoscopic therapy of T1a esophageal adenocarcinoma (EAC) yields more quality-adjusted life years (QALYs) and is more cost effective than esophagectomy, shows a Markov model analysis published in the March issue of Clinical Gastroenterology and Hepatology. However, therapy for T1b EAC should be selected based on patients’ age and comorbidities. Although EAC has

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  • Review: How Does the Tumor Stroma Contribute to Pancreatic Cancer Progression, and Can We Stop It?

Review: How Does the Tumor Stroma Contribute to Pancreatic Cancer Progression, and Can We Stop It?

Recently developed approaches for reshaping the pancreatic tumor stroma might be used in treatments for pancreatic cancer, according to a review in the March issue of Gastroenterology. The authors discuss relationships among the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and how these might be manipulated to stop pancreatic tumor

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  • Why is Gallbladder Cancer Mortality Decreasing in Some Countries but Increasing in Others?

Why is Gallbladder Cancer Mortality Decreasing in Some Countries but Increasing in Others?

Deaths from gallbladder and other biliary tract cancers are decreasing in most countries, but increasing in some high-income countries following decades of decline, researchers report in the March issue of Clinical Gastroenterology and Hepatology. These emerging trends may reflect lifestyle changes, such as increases in excess body weight. Gallbladder cancer is

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  • VIDEO: Non-invasive Detection of Early- and Late-Stage PDAC

VIDEO: Non-invasive Detection of Early- and Late-Stage PDAC

Specific patterns of volatile organic compounds (VOCs) in urine samples can identify patients with pancreatic ductal adenocarcinoma (PDAC), researchers report in the February issue of Gastroenterology. The noninvasive technology, based on ion mobility spectrometry, can be used to discriminate between healthy individuals vs individuals with early- or advanced-stage cancer. VOCs are metabolic products of microbes that can

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  • Are Patients With PSC and Colitis More likely to Have Subclinical Inflammation?

Are Patients With PSC and Colitis More likely to Have Subclinical Inflammation?

Patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) in remission are significantly more likely to have inflammation of the right colon, based on endoscopic and histologic markers, than patients with UC without PSC, researchers report in the January issue of Clinical Gastroenterology and Hepatology. These findings provide insight into cause

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  • Which Patients With Flat Low-grade Dysplasia are at High Risk for Colorectal Cancer?

Which Patients With Flat Low-grade Dysplasia are at High Risk for Colorectal Cancer?

Detection of flat low-grade dysplasia (fLGD) and aneuploidy in colon tissues increases risk for high-grade dysplaisa (HGD) or colorectal cancer (CRC) more than 5-fold in patients with inflammatory bowel disease (IBD), researchers report in the December issue of Gastroenterology. Aneuploidy was also detected in almost all cases of flat HGD (fHGD) IBD is a risk

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  • Review: Pathogenesis and Prevention of Gastric Cancer

Review: Pathogenesis and Prevention of Gastric Cancer

New diagnostic protocols, effective medical treatments, and recently developed conservative ablative procedures could make gastric cancer a preventable malignancy, says a review article in the December issue of Clinical Gastroenterology and Hepatology. Gastric cancer is 1 of the 5 most common causes of cancer death, and only 30% of patients survive 5

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  • Intestinal Microbes as Carcinogens

Intestinal Microbes as Carcinogens

Fecal microbiota from patients with colorectal cancer (CRC) have carcinogenic properties, researchers report in the December issue of Gastroenterology. Feeding mice stool from patients with colorectal cancer (CRC) increased numbers of polyps, levels of intestinal dysplasia and proliferation, and markers of inflammation in colon, compared with stool from individuals without CRC, the scientists found.

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