Cancer
  • Should We Screen for HCC?

Should We Screen for HCC?

Screening patients with cirrhosis for hepatocellular carcinoma (HCC) by abdominal ultrasonography (USS) and/or measurement of serum level of alpha-fetoprotein (AFP) is not associated with reduced mortality from this cancer, reseachers report from a matched case–control study in the October issue of Gastroenterology. Patients with cirrhosis have a high risk (1%–8%

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  • Effects of Diet, Intestinal Inflammation, and the Microbiome on Risk of Colorectal Cancer

Effects of Diet, Intestinal Inflammation, and the Microbiome on Risk of Colorectal Cancer

Diets that promote intestinal inflammation can increase risk of colorectal carcinomas associated with specific bacteria in the microbiome, researchers report in the October issue of Clinical Gastroenterology and Hepatology. Diet-induced intestinal inflammation alters the gut microbiome to contribute to colorectal cancer risk, which might be reduced with dietary changes. Chronic inflammation

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  • How Does Cigarette Smoke Promote Pancreatic Tumor Development?

How Does Cigarette Smoke Promote Pancreatic Tumor Development?

Exposure to cigarette smoke activates stem cell features in pancreatic cells, via nicotinic cholinergic receptor signaling to transcription factors that activate expression of stem cell genes, researchers report in the September issue of Gastroenterology. Levels of the stem cell transcriptional regulator PAF1 are increased in pancreatic tumors from humans and

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  • Hyperglycemia as a Marker for Early Detection of Pancreatic Cancer

Hyperglycemia as a Marker for Early Detection of Pancreatic Cancer

Patients are hyperglycemic for a mean period of 36 to 30 months before a diagnosis of pancreatic ductal adenocarcinoma (PDAC), researchers report in the August issue of Gastroenterology. This information might be used in strategies for early detection. At the time of PDAC diagnosis, approximately 85% of subjects have hyperglycemia

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  • 500 Posts by the AGA Journals Blog

500 Posts by the AGA Journals Blog

This week the AGA Journals Blog has reached an important milestone — its 500th post! The blog was started in 2010 to help disseminate the important discoveries published in the AGA Journals to a broader audience. Eight years and over 132,000 views later, it has updated its readers on everything from biomarkers for colon

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  • A Genetic Cause for Multiple Adenomas and Diabetes in a Young Patient

A Genetic Cause for Multiple Adenomas and Diabetes in a Young Patient

Researchers report a case of a patient with multiple adenomas and a family history of young-onset diabetes and hepatocellular carcinoma. They found these to be caused by a mutation in the HNF1 homeobox A gene (HNF1A), which caused maturity onset diabetes of the young type 3 (MODY3). Tom J. Harryvan et al evaluated a

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  • Does Acute Pancreatitis Increase Risk of Pancreatic Cancer?

Does Acute Pancreatitis Increase Risk of Pancreatic Cancer?

Patients hospitalized with acute pancreatitis have a 2-fold increased risk of pancreatic cancer compared with the general population, researchers report in the May issue of Gastroenterology. Acute pancreatitis is a sudden-onset inflammatory disease of the pancreas. Although acute pancreatitis promotes development of pancreatic cancer in mouse models, there have been conflicting findings from epidemiology

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  • Does Drinking Coffee Increase Survival of Patients With Colorectal Cancer?

Does Drinking Coffee Increase Survival of Patients With Colorectal Cancer?

Drinking 2 or more cups of coffee per day after a diagnosis of stage I to III colorectal cancer (CRC) reduces risk of CRC-specific and all-cause mortality, researchers report in the March issue of Gastroenterology. Patients who maintain a high level of coffee consumption before and after diagnosis have even better odds for survival.

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  • Surgical vs Endoscopic Treatment of T1 Esophageal Adenocarcinoma?

Surgical vs Endoscopic Treatment of T1 Esophageal Adenocarcinoma?

Endoscopic therapy of T1a esophageal adenocarcinoma (EAC) yields more quality-adjusted life years (QALYs) and is more cost effective than esophagectomy, shows a Markov model analysis published in the March issue of Clinical Gastroenterology and Hepatology. However, therapy for T1b EAC should be selected based on patients’ age and comorbidities. Although EAC has

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  • Review: How Does the Tumor Stroma Contribute to Pancreatic Cancer Progression, and Can We Stop It?

Review: How Does the Tumor Stroma Contribute to Pancreatic Cancer Progression, and Can We Stop It?

Recently developed approaches for reshaping the pancreatic tumor stroma might be used in treatments for pancreatic cancer, according to a review in the March issue of Gastroenterology. The authors discuss relationships among the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and how these might be manipulated to stop pancreatic tumor

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