Cancer

Cleaning for Colonoscopy

GoLytely better prepares the colon for screening colonoscopy than MiraLAX, report Michael Hjelkrem et al. in the April issue of Clinical Gastroenterology and Hepatology. Efficient cleansing of the colon is one of the most important factors for successful colonscopy examination, but also a major reason that patients avoid screening—because of

Read more

Tracking Pancreatic Cancer Cells

Tumors spread to other parts of the body when cancer cells can escape into the bloodstream, although it is not exactly clear how they enter the circulation or decide where to form new tumors. Andrew Rhim and colleagues at the University of Pennsylvania have developed a technology to label tumor

Read more

Anti-Inflammatory Drugs Prevent Colorectal Cancer (for Some)

Aspirin and other anti-inflammatory drugs prevent colorectal cancer (CRC) in some people but not others, according to the March issue of Gastroenterology. Andrew Chan et al. found that these drugs reduce the risk of CRC only in women with high levels of soluble tumor necrosis factor receptor 2 (sTNFR-2), a

Read more

An HIV Protein and Telomerase Inhibitor Join Forces Against Cancer

Researchers have found a way to specifically kill liver cancer cells and stop tumor growth. In the January issue of Gastroenterology, Guangming Chen et al. report that fusion of a natural inhibitor of telomerase to an HIV protein stops proliferation of hepatocellular carcinoma (HCC) cells and growth of liver tumors

Read more

Colorectal Cancer in Cowden Syndrome

Patients with Cowden syndrome (CS) are at high risk for early-onset colorectal cancer, according to the December issue of Gastroenterology. CS is caused by mutations in the tumor suppressor gene phosphatase and tensin homolog (PTEN). Patients typically have mucocutaneous lesions, large-sized heads, and increased risk for breast, thyroid, and endometrial

Read more

In CRC Screening, Location Matters

Colonoscopy screening reduces mortality from cancers of the distal, but not proximal, colon, according to a study published in the October issue of Gastroenterology. Harminder Singh et al. studied mortality from CRC among more than 55,000 people that had received screening colonoscopies, compared with the general population. They found that

Read more

Who Has the Greatest Risk for Colorectal Cancer?

Men and smokers have the greatest risk for developing colorectal neoplasms—even more than people with a family history of this cancer—according to Michael Hoffmeister et al. in the October issue of Clinical Gastroenterology and Hepatology. Current guidelines recommend that individuals with a family history of colorectal cancer (CRC), inflammatory bowel

Read more

How Prevalent are Pancreatic Cysts?

As more patients have undergone imaging examinations for various disorders, physicians have detected pancreatic cysts with increasing frequency. Some cysts become malignant yet many remain asymptomatic. However, the prevalence of pancreatic cysts among healthy individuals has not been established—it is important to determine how common these are, to devise strategies

Read more

Curbing Crohn’s for the Long Term?

Most people with Crohn’s disease receive surgery, yet the disease comes back a short time later. A study in the July issue of Clinical Gastroenterology and Hepatology reports that giving patients low doses of infliximab immediately after surgery prevents disease recurrence over long time periods. Dario Sorrentino et al. began

Read more

Does Polyp Size Matter?

Computed tomography colonography (CTC) is a useful tool for colon cancer screening. The challenge, however, is determining which lesions are most dangerous—should some be treated aggressively and others just monitored or ignored? Does size matter? In the July issue of Clinical Gastroenterology and Hepatology, Perry Pickhardt et al. assessed the

Read more