Cancer
  • Why do Pancreatic Tumor Cells Love the Liver?

Why do Pancreatic Tumor Cells Love the Liver?

Pancreatic ductal adenocarcinoma (PDAC) and its precursors secrete high levels of tissue inhibitor of metalloproteinases 1 (TIMP1) into the circulation, which activates hepatic stellate cells (HSCs) in liver. These cells help create a niche that promotes metastasis of pancreatic tumors to liver, researchers report in the November issue of Gastroenterology.

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  • A Mouse Model for Studying Pancreatic Tumor Resection and Adjuvant Therapy

A Mouse Model for Studying Pancreatic Tumor Resection and Adjuvant Therapy

Researchers have developed mice that develop focal, resectable pancreatic tumors closely resembling human pancreatic ductal adenocarcinomas (PDACs) that can be used to test adjuvant therapies, according to new research in the August issue of Gastroenterology. The authors show that administration of gemcitabine after resection of the tumors activates natural killer (NK) cell-mediated

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  • Why Isn’t Radiation Therapy Effective for Pancreatic Tumors?

Why Isn’t Radiation Therapy Effective for Pancreatic Tumors?

In pancreatic tumors of mice, radiation causes infiltration by macrophages that acquire an immune-suppressive phenotype that disables T-cell–mediated anti-tumor responses, researchers report in the June issue of Gastroenterology. Blocking colony stimulating factor (CSF1 or MCSF) prevents this process, allowing radiation to slow tumor growth, they show. Most patients with pancreatic

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  • Gastroenterology Special Isssue on Alcoholic vs Non-Alcoholic Fatty Liver Disease

Gastroenterology Special Isssue on Alcoholic vs Non-Alcoholic Fatty Liver Disease

A special issue of Gastroenterology is devoted to comparing alcoholic vs nonalcoholic fatty liver disease. In an introduction to the issue, Arun Sanyal et al write that alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) have much in common, including histologic features and activation of pathways involved in their pathogenesis. They also have some

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  • What can we do with Gastrointestinal Organoids?

What can we do with Gastrointestinal Organoids?

Researchers review the latest discoveries from studies of tissue-derived and pluripotent stem cell–derived intestinal, gastric, esophageal, liver, and pancreatic organoids in the May issue of Gastroenterology. Studies of organoids have provided valuable information about GI development, tissue homeostasis, and disease and might be used to develop personalized medicines. In vitro organoid cultures are

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What is Causing the Increased Detection of Pancreatic Cysts?

Advances in imaging technologies over the past decades have greatly increased the numbers of pancreatic cysts detected, researchers report in the April issue of Clinical Gastroenterology and Hepatology. With further improvements in pancreatic imaging, more pancreatic cysts are likely to be discovered, so gastroenterologists, surgeons, endoscopic ultrasound specialists, and primary

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  • Can Statin Use After Diagnosis of Esophageal Cancer Prolong Survival?

Can Statin Use After Diagnosis of Esophageal Cancer Prolong Survival?

Statin use after a diagnosis of esophageal adenocarcinoma, but not esophageal squamous cell carcinoma, reduces esophageal cancer–specific and all-cause mortality, researchers report in the April issue of Gastroenterology. Esophageal cancer is the fifth most common cause of cancer-related death in men and eighth most common cause in women, worldwide. Esophageal

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  • Alcohol Consumption and Fatty Liver—A Double Whammy for Liver Cancer Risk

Alcohol Consumption and Fatty Liver—A Double Whammy for Liver Cancer Risk

High to intermediate levels of ethanol consumption increase the risk for liver cancer in patients with fatty liver disease, researchers report in the April issue of Clinical Gastroenterology and Hepatology. Nonalcoholic fatty liver disease is a common cause of chronic liver disease associated with obesity, dyslipidemia, pituitary dysfunction, hypertension, sleep

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  • Distinguishing a Pancreatic Pseudocyst from a Mucinous Cystic Neoplasm

Distinguishing a Pancreatic Pseudocyst from a Mucinous Cystic Neoplasm

Researchers describe the case of a patient with what appeared to be a pancreatic pseudocyst that was found to be a benign mucinous cystic neoplasm (MCN), based on analysis of a cyst wall biopsy. In the March issue of Gastroenterology, Katie Connor et al  describe a 22-year-old woman who came

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Pancreaticobiliary Maljunction and Neuroendocrine Carcinoma

Researchers describe an unusual case—a patient with a neuroendocrine carcinoma of the gallbladder accompanied by pancreaticobiliary maljunction—in the March issue of Clinical Gastroenterology and Hepatology. Tomonori Matsumoto et al examined a 58-year-old man with epigastric pain. Computed tomography (A) and fluoro-2-deoxy-d-glucose positron emission tomography (B) revealed angular diffuse thickening of the gallbladder

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