Cancer
  • Alcohol Consumption and Fatty Liver—A Double Whammy for Liver Cancer Risk

Alcohol Consumption and Fatty Liver—A Double Whammy for Liver Cancer Risk

High to intermediate levels of ethanol consumption increase the risk for liver cancer in patients with fatty liver disease, researchers report in the April issue of Clinical Gastroenterology and Hepatology. Nonalcoholic fatty liver disease is a common cause of chronic liver disease associated with obesity, dyslipidemia, pituitary dysfunction, hypertension, sleep

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  • Distinguishing a Pancreatic Pseudocyst from a Mucinous Cystic Neoplasm

Distinguishing a Pancreatic Pseudocyst from a Mucinous Cystic Neoplasm

Researchers describe the case of a patient with what appeared to be a pancreatic pseudocyst that was found to be a benign mucinous cystic neoplasm (MCN), based on analysis of a cyst wall biopsy. In the March issue of Gastroenterology, Katie Connor et al  describe a 22-year-old woman who came

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Pancreaticobiliary Maljunction and Neuroendocrine Carcinoma

Researchers describe an unusual case—a patient with a neuroendocrine carcinoma of the gallbladder accompanied by pancreaticobiliary maljunction—in the March issue of Clinical Gastroenterology and Hepatology. Tomonori Matsumoto et al examined a 58-year-old man with epigastric pain. Computed tomography (A) and fluoro-2-deoxy-d-glucose positron emission tomography (B) revealed angular diffuse thickening of the gallbladder

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Does IBD Increase Risk for Oral Cancer?

Patients with inflammatory bowel diseases (IBD) have an increased risk of oral cancers—especially tongue cancer—researchers report in the March issue of Clinical Gastroenterology and Hepatology. Women are at higher risk than men. Oral cancers develop in the mucosal surfaces of the lips, floor of mouth, tongue, buccal mucosa, lower and

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  • Does a PNPLA3 Polymorphism Promote Fibrosis Progression in Patients with Hepatitis C?

Does a PNPLA3 Polymorphism Promote Fibrosis Progression in Patients with Hepatitis C?

A single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain containing 3 gene (PNPLA3) is associated with baseline level of fibrosis and its progression, but not development of hepatocellular carcinoma (HCC), in patients with hepatitis C virus (HCV) infection, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Most

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  • A Nanoparticle-based Approach to Selectively Target Hepatocellular Carcinomas

A Nanoparticle-based Approach to Selectively Target Hepatocellular Carcinomas

Researchers have created nanoparticles that selectively kill hepatoma cells and reduce growth of liver tumors in rats, they report in the February issue of Gastroenterology. They show that the particles induce tumor-specific necrosis by selectively disrupting redox balance within cancer cells. Dietary intake of the natural omega-3 fatty acid docosahexaenoic

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  • Can a Cocktail Prevent Colorectal Adenoma Recurrence?

Can a Cocktail Prevent Colorectal Adenoma Recurrence?

The combination of calcitriol, aspirin, and calcium carbonate did not prevent recurrence of colorectal adenomas over a 3-year period, found a prospective study published in the January issue of Gastroenterology. This negative result might have been affected by the numbers of smokers included in the study or low doses of

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  • Finding Circulating Tumor Cells in Patients With Pancreaticobiliary Cancers

Finding Circulating Tumor Cells in Patients With Pancreaticobiliary Cancers

Circulating tumor cells (CTCs) can be isolated from portal venous blood collected during endoscopic ultrasound (EUS) of patients with pancreaticobiliary cancers, researchers report in the December issue of Gastroenterology. CTCs isolated from peripheral blood of patients with metastatic breast, colorectal, or prostate cancer can be analyzed to predict patient survival. However, blood samples from

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  • Do Patients Really Prefer Colon Capsule Endoscopy Over Colonoscopy?

Do Patients Really Prefer Colon Capsule Endoscopy Over Colonoscopy?

Slightly more than 50% of people with an inherited risk for colorectal cancer (CRC) agree to undergo screening for this cancer, and most prefer colonoscopy to colon capsule endoscopy—even though these are equally effective screening tools—researchers report in the December issue of Clinical Gastroenterology and Hepatology. Colonoscopy should therefore remain

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  • Special Issue: Managing Patients With Liver Disease

Special Issue: Managing Patients With Liver Disease

A special issue of Clinical Gastroenterology and Hepatology is dedicated to the clinical management of hepatic disorders, including nonalcoholic fatty liver disease (NAFLD), viral hepatitis, autoimmune hepatitis, and primary sclerosing cholangitis (PSC). The issue comprises 14 review articles that aim to present clinicians with evidence-based guidance and expert opinions on management of patients with liver

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