GI Tract
  • REVIEW: How Does Barrett’s Esophagus Develop?

REVIEW: How Does Barrett’s Esophagus Develop?

Mechanisms of Barrett’s esophagus (BE) pathogenesis are discussed in a review article by Jianwen Que et al in the August issue of Gastroenterology, including cell transdifferentiation and transcommitment. The authors discuss potential cells of origin for Barrett’s metaplasia, and the possibility that there could be more than 1 type of BE

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  • How Does Gastroparesis Vary Among Different People?

How Does Gastroparesis Vary Among Different People?

Gastroparesis causes, symptoms, and treatments vary among patients of different races, ethnicities, and sexes, researchers report in the July issue of Clinical Gastroenterology and Hepatology. The prevalence of some gastrointestinal (GI) disorders varies with race and ethnicity. For example, dyspepsia and irritable bowel syndrome are reported less frequently by African Americans.

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  • How Does Gastric Adenocarcinoma Develop?

How Does Gastric Adenocarcinoma Develop?

Overexpression of the peroxisome proliferator-activated receptor delta (PPARD) in gastric progenitor cells results in inflammation, dysplasia, and tumor formation in mice, researchers report in the July issue of Gastroenterology. Strategies to reduce PPARD in gastric progenitor cells might lead to treatments for stomach cancer. Gastric carcinogenesis is associated with chronic inflammation. The

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  • What is the Best Personality for an Endoscopist?

What is the Best Personality for an Endoscopist?

Researchers show that you want your endoscopist to be a type-A person — adenoma detect rates (ADRs) are higher among physicians who describe themselves as more compulsive or thorough, researchers report in the July issue of Clinical Gastroenterology and Hepatology. There was no association between ADR and financial incentives, malpractice concerns,

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  • Can Altering the Intestinal Microbiome Reduce Wheat Sensitivity?

Can Altering the Intestinal Microbiome Reduce Wheat Sensitivity?

Amylase trypsin inhibitors (ATIs), which are enzymes in wheat, promote intestinal dysfunction and exacerbate inflammation in response to gluten, researchers show in study of mice published in the June issue of Gastroenterology. Strategies to alter the intestinal microbiome, such as administration of bacteria with ATI-degrading capacity, might be effective for

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  • A Case of Spirochetosis That Resembles IBD

A Case of Spirochetosis That Resembles IBD

Researchers describe a patient with intestinal spirochetosis—a rare intestinal infection caused by Brachyspira aalborgi or Brachyspira pilosicoli that can involve the colon or terminal ileum and mimic inflammatory bowel diseases—in the May issue of Clinical Gastroenterology and Hepatology. Manasi Agrawal et al report the case of a 45-year-old man with HIV infection and an undetectable viral

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  • Can a Food-based Diet Replace Exclusive Enteral Nutrition for Patients With Crohn’s Disease?

Can a Food-based Diet Replace Exclusive Enteral Nutrition for Patients With Crohn’s Disease?

An individualized, food-based diet with similar composition of nutrients to exclusive enteral nutrition (EEN), causes similar changes in the microbiomes of patients with Crohn’s disease (CD), reduces gut inflammation, and is preferred by patients, researchers report in the April issue of Gastroenterology. Non-medical treatments are needed for patients with CD. Diet

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  • Can Surveillance be Extended or Eliminated for Some Patients With Barrett’s Esophagus?

Can Surveillance be Extended or Eliminated for Some Patients With Barrett’s Esophagus?

Two articles in the April issue of Clinical Gastroenterology and Hepatology show that surveillance intervals might be lengthened or even discontinued for subgroups of patients with Barrett’s esophagus. Stable non-dysplastic Barrett’s esophagus (NDBE) has a low risk of progression to high-grade dysplaisa (HGD) or esophageal adenocarcinoma (EAC), Yonne Peters et al

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  • IBD Research Highlights from 2019 ECCO Congress

IBD Research Highlights from 2019 ECCO Congress

A variety of exciting findings from inflammatory bowel disease (IBD) research were presented at the Congress of the European Crohn’s and Colitis Organisation (ECCO), held in Copenhagen, March 7–9. Shixian Hu (Universitair Medisch Centrum Groningen, The Netherlands) reported on associations between genetic factors and the microbiome in patients with IBD.

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  • REVIEW: Combining CRISPR-Cas9 and Organoid Technologies to Study Gastrointestinal Diseases

REVIEW: Combining CRISPR-Cas9 and Organoid Technologies to Study Gastrointestinal Diseases

CRISPR-Cas9 technology can be used to engineer organoids for studies of gastrointestinal development and disease pathogenesis. In the February issue of Gastroenterology, Masayuki Fujii et al review derivation of organoids from human gastrointestinal tissues and how CRISPR-Cas9 has advanced studies of the digestive system. CRISPR-Cas9 genome editing technology allows researchers to

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