GI Tract
  • What is in Transplanted Fecal Microbiota That Cures Clostridium difficile Infection?

What is in Transplanted Fecal Microbiota That Cures Clostridium difficile Infection?

Researchers have identified a microbiota metabolite that is depleted by the antibiotic clindamycin and replaced with fecal microbiota transplantation (FMT), mediating its effects on recurrent Clostridioides difficile (Clostridium difficile) infection (CDI). Reporting in the November issue of Gastroenterology, the researchers propose that this bacterial metabolite, valerate, might be used in safer and

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  • What Endoscopic Techniques are Available for Weight Loss?

What Endoscopic Techniques are Available for Weight Loss?

Endoscopic techniques have been approved by the FDA for management of obesity, with many new devices and technologies in development. The pros and cons of these approaches, and the questions to be answered, are covered in a review article by Andrew C. Storm et al in the November issue of Clinical

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  • Effects of Diet, Intestinal Inflammation, and the Microbiome on Risk of Colorectal Cancer

Effects of Diet, Intestinal Inflammation, and the Microbiome on Risk of Colorectal Cancer

Diets that promote intestinal inflammation can increase risk of colorectal carcinomas associated with specific bacteria in the microbiome, researchers report in the October issue of Clinical Gastroenterology and Hepatology. Diet-induced intestinal inflammation alters the gut microbiome to contribute to colorectal cancer risk, which might be reduced with dietary changes. Chronic inflammation

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  • Are Prebiotics or Diets Low in FODMAPs Better for Patients With Functional GI Disorders?

Are Prebiotics or Diets Low in FODMAPs Better for Patients With Functional GI Disorders?

Intermittent administration of prebiotics might be an alternative to dietary restrictions for patients with functional gut symptoms, researchers report in the October issue of Gastroenterology. A diet low in fermentable oligo-, di-, mono-saccharides and polyols (low-FODMAP diet) reduces symptoms of irritable bowel syndrome (IBS), and patients with gas-related symptoms can significantly

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  • Decreased Microvilli Length, and Associated Gene Expression Changes, in Patients With Crohn’s Disease

Decreased Microvilli Length, and Associated Gene Expression Changes, in Patients With Crohn’s Disease

In an analysis of intestinal tissues from patients with Crohn’s disease (CD), researchers identified specific changes in gene expression patterns that associate with histologic changes, such as differences in microvilli length. Decreased microvilli length, via decreased expression of the microvilli gene set, might contribute to epithelial malfunction and the chronic

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  • Dyspepsia and Hyperamylasemia Due to Plastic Spork Ingestion

Dyspepsia and Hyperamylasemia Due to Plastic Spork Ingestion

Researchers report a case of abdominal pain and hyperamylasemia due a duodenal foreign body in the September issue of Clinical Gastroenterology and Hepatology. Lotje Korteweg et al describe the case of a 38-year old man referred for endoscopic retrograde cholangiopancreatography. A gastroduodenoscopy had been performed for chronic dyspepsia and showed

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  • Is it Safe or Effective to Combine Therapies for Inflammatory Bowel Diseases?

Is it Safe or Effective to Combine Therapies for Inflammatory Bowel Diseases?

Little is known about the efficacy and safety of combination targeted therapy for inflammatory bowel diseases (IBD), despite their use in treatment of other immune-mediated disorders. In a review article in the September issue of Clinical Gastroenterology and Hepatology, Robert P. Hirten et al discuss findings from studies of biologic

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  • 500 Posts by the AGA Journals Blog

500 Posts by the AGA Journals Blog

This week the AGA Journals Blog has reached an important milestone — its 500th post! The blog was started in 2010 to help disseminate the important discoveries published in the AGA Journals to a broader audience. Eight years and over 132,000 views later, it has updated its readers on everything from biomarkers for colon

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  • What are the Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis?

What are the Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis?

Vitamin K antagonists (VKAs) increase risk of minor bleeding in patients with cirrhosis given anticoagulants for portal vein thrombosis (PVT), compared to patients without cirrhosis given VKAs, researchers report in the July issue of Clinical Gastroenterology and Hepatology. However, this risk is offset by the ability of VKA to increase portal

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  • Does Mucosal Healing Mean Transmural Healing in Children With Crohn’s Disease?

Does Mucosal Healing Mean Transmural Healing in Children With Crohn’s Disease?

 One-third of children with Crohn’s disease have healing in only the mucosa or the bowel wall (not both), researchers report in the July issue of Clinical Gastroenterology and Hepatology. Levels of fecal calprotectin below 300 μg/identify children with mucosal healing. In patients with CD, mucosal healing is associated with reduced risk of relapse,

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