GI Tract
  • Dyspepsia and Hyperamylasemia Due to Plastic Spork Ingestion

Dyspepsia and Hyperamylasemia Due to Plastic Spork Ingestion

Researchers report a case of abdominal pain and hyperamylasemia due a duodenal foreign body in the September issue of Clinical Gastroenterology and Hepatology. Lotje Korteweg et al describe the case of a 38-year old man referred for endoscopic retrograde cholangiopancreatography. A gastroduodenoscopy had been performed for chronic dyspepsia and showed

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  • Is it Safe or Effective to Combine Therapies for Inflammatory Bowel Diseases?

Is it Safe or Effective to Combine Therapies for Inflammatory Bowel Diseases?

Little is known about the efficacy and safety of combination targeted therapy for inflammatory bowel diseases (IBD), despite their use in treatment of other immune-mediated disorders. In a review article in the September issue of Clinical Gastroenterology and Hepatology, Robert P. Hirten et al discuss findings from studies of biologic

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  • 500 Posts by the AGA Journals Blog

500 Posts by the AGA Journals Blog

This week the AGA Journals Blog has reached an important milestone — its 500th post! The blog was started in 2010 to help disseminate the important discoveries published in the AGA Journals to a broader audience. Eight years and over 132,000 views later, it has updated its readers on everything from biomarkers for colon

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  • What are the Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis?

What are the Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis?

Vitamin K antagonists (VKAs) increase risk of minor bleeding in patients with cirrhosis given anticoagulants for portal vein thrombosis (PVT), compared to patients without cirrhosis given VKAs, researchers report in the July issue of Clinical Gastroenterology and Hepatology. However, this risk is offset by the ability of VKA to increase portal

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  • Does Mucosal Healing Mean Transmural Healing in Children With Crohn’s Disease?

Does Mucosal Healing Mean Transmural Healing in Children With Crohn’s Disease?

 One-third of children with Crohn’s disease have healing in only the mucosa or the bowel wall (not both), researchers report in the July issue of Clinical Gastroenterology and Hepatology. Levels of fecal calprotectin below 300 μg/identify children with mucosal healing. In patients with CD, mucosal healing is associated with reduced risk of relapse,

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  • Are Eating Competitions Dangerous?

Are Eating Competitions Dangerous?

The stomachs of competitive eaters accommodate large quantities of food by repeated rapid distension of the gastric wall during eating episodes. A Clinical Challenges and Images in GI article in the June issue of Gastroenterology presents an adverse outcome of these competitions. Tian-Zhi Lim et al describe the case of a 30-year-old, healthy man

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  • Does Mucosal Inflammation Cause Diverticulosis?

Does Mucosal Inflammation Cause Diverticulosis?

Despite limited evidence that a chronic state of low-grade mucosal inflammation contributes to development of diverticulosis, a prospective study published in the June issue of Clinical Gastroenterology and Hepatology found no correlation of the disease with mucosal inflammation, upregulated immune markers, or gastrointestinal symptoms. Colonic diverticulosis (outpouchings from the colonic lumen) is

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Gastroenterology Special Issue on Endoscopy

A special issue of Gastroenterology, Advances in Endoscopic Therapy, presents the latest advances in gastrointestinal endoscopy, including endoscopic images and videos. In their introductory article, Jacques J. Bergman and Patrick S. Yachimski explain that endoscopy is central to gastroenterology clinical practice and research, allowing examination of healthy and diseased tissue from the organ level, to the

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  • What Changes Occur in the Esophageal Epithelial Barrier During Disease Development?

What Changes Occur in the Esophageal Epithelial Barrier During Disease Development?

A review article in the May issue of Clinical Gastroenterology and Hepatology discusses esophageal epithelial barrier structure and function, new and old techniques for studying this barrier, and changes that occur during development of esophageal diseases. To identify mechanisms of diseases associated with barrier dysfunction, such as gastroesophageal reflux disease (GERD), eosinophilic esophagitis,

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  • What Are the Best Endpoints for Trials of Agents for Ulcerative Colitis?

What Are the Best Endpoints for Trials of Agents for Ulcerative Colitis?

Despite advances in methods of clinical trials for ulcerative colitis (UC), there is still a large amount of variation in endpoints, even in definitions of response and remission, reseachers found in a systematic review published in the May issue of Clinical Gastroenterology and Hepatology. The authors conclude that we need a

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