GI Tract
  • Can a Food-based Diet Replace Exclusive Enteral Nutrition for Patients With Crohn’s Disease?

Can a Food-based Diet Replace Exclusive Enteral Nutrition for Patients With Crohn’s Disease?

An individualized, food-based diet with similar composition of nutrients to exclusive enteral nutrition (EEN), causes similar changes in the microbiomes of patients with Crohn’s disease (CD), reduces gut inflammation, and is preferred by patients, researchers report in the April issue of Gastroenterology. Non-medical treatments are needed for patients with CD. Diet

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  • Can Surveillance be Extended or Eliminated for Some Patients With Barrett’s Esophagus?

Can Surveillance be Extended or Eliminated for Some Patients With Barrett’s Esophagus?

Two articles in the April issue of Clinical Gastroenterology and Hepatology show that surveillance intervals might be lengthened or even discontinued for subgroups of patients with Barrett’s esophagus. Stable non-dysplastic Barrett’s esophagus (NDBE) has a low risk of progression to high-grade dysplaisa (HGD) or esophageal adenocarcinoma (EAC), Yonne Peters et al

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  • IBD Research Highlights from 2019 ECCO Congress

IBD Research Highlights from 2019 ECCO Congress

A variety of exciting findings from inflammatory bowel disease (IBD) research were presented at the Congress of the European Crohn’s and Colitis Organisation (ECCO), held in Copenhagen, March 7–9. Shixian Hu (Universitair Medisch Centrum Groningen, The Netherlands) reported on associations between genetic factors and the microbiome in patients with IBD.

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  • REVIEW: Combining CRISPR-Cas9 and Organoid Technologies to Study Gastrointestinal Diseases

REVIEW: Combining CRISPR-Cas9 and Organoid Technologies to Study Gastrointestinal Diseases

CRISPR-Cas9 technology can be used to engineer organoids for studies of gastrointestinal development and disease pathogenesis. In the February issue of Gastroenterology, Masayuki Fujii et al review derivation of organoids from human gastrointestinal tissues and how CRISPR-Cas9 has advanced studies of the digestive system. CRISPR-Cas9 genome editing technology allows researchers to

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  • REVIEW: Balancing Benefit vs Risk of Immunosuppressive Therapy for IBD

REVIEW: Balancing Benefit vs Risk of Immunosuppressive Therapy for IBD

Inflammatory bowel diseases (IBD) and their treatments, particularly immunosuppressive drugs, increase risk of infections and cancers. However, by promoting mucosal healing, these agents reduce risks of infections related to intestinal lesions, malnutrition, intravenous devices, and IBD surgeries and reduce risk of cancers associated with chronic mucosal inflammation. Laurent Beaugerie and Julien Kirchgesner

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  • Can an Antibody Against IL13 Be Used to Treat Eosinophilic Esophagitis?

Can an Antibody Against IL13 Be Used to Treat Eosinophilic Esophagitis?

A monoclonal antibody against IL13 reduced histologic and endoscopic features of eosinophilic esophagitis (EoE) in a placebo-controlled phase 2 trial, researchers report in the February issue of Gastroenterology. The antibody, called RPC4046, was well tolerated. EoE is a chronic, immune-mediated disease of the esophagus characterized by eosinophil-mediated mucosal inflammation and

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  • Combined Genetic and Clinical Data Do Not Improve Determination of Risk for Esophageal Adenocarcinoma

Combined Genetic and Clinical Data Do Not Improve Determination of Risk for Esophageal Adenocarcinoma

Addition of genetic information to clinical factors does not increase identification of individuals at risk for esophageal adenocarcinoma, researchers report in the January 2019 issue of Gastroenterology. New screening and risk evaluation methods are needed to improve early detection of esophageal adenocarcinoma, because most patients receive a diagnosis at a late

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  • Simple Process for Generating Unlimited Intestinal Stem Cells From Endoscopic Biopsies

Simple Process for Generating Unlimited Intestinal Stem Cells From Endoscopic Biopsies

An efficient method for cloning gastrointestinal stem cells from biopsies collected during endoscopy is reported in the January isssue of Gastroenterology. A system is needed to isolate, clone, and examine the mucosal stem cells away from confounding effects of immune, stromal, and microbe cells. Markers of stem cells such as

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Review: Why Do We Know So Little About Hemorrhoids?

The time has come for targeted research to understand the causes, symptoms, and best treatment for patients with symptomatic hemorrhoids, write Robert S. Sandler and Anne F. Peery in a review article in the January issue of Clinical Gastroenterology and Hepatology. Although hemorrhoids are responsible for considerable economic cost and

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  • How Can You Identify a Patient With Idiopathic Myointimal Hyperplasia of the Mesenteric Veins?

How Can You Identify a Patient With Idiopathic Myointimal Hyperplasia of the Mesenteric Veins?

Researchers report a case of vascular alterations with inflammation and evidence of venous outflow tract due to idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) in the January issue of Gastroenterology. Michiel Bronswijk et al describe a 67-year-old man with a history of obesity, type 2 diabetes, and hemochromatosis admitted to

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