GI Tract
  • What are the Complications of Proton Pump Inhibitor Therapy?

What are the Complications of Proton Pump Inhibitor Therapy?

A review article from Michael F. Vaezi et al discusses potential adverse consequences of proton-pump inhibitor (PPI) therapy in the July issue of Gastroenterology. Proton pump inhibitors (PPIs) are among the most commonly prescribed medicines for gastroesophageal reflux disease (GERD) and peptic ulcer disease. Multiple randomized controlled trials of PPIs have shown efficacy

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  • What Comes First — the Psychological Disorder or the Gastrointestinal Disorder?

What Comes First — the Psychological Disorder or the Gastrointestinal Disorder?

More patients receive a diagnosis of a mood or anxiety disorder before diagnosis of a functional gastrointestinal disorder (FGID), researchers report in the July issue of Clinical Gastroenterology and Hepatology. The findings indicate opportunities for prevention and support the role of adverse socioeconomic factors in development of FGIDs in patients

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  • The Case of the Missing Acupuncture Needle – Solved by 3-D CT

The Case of the Missing Acupuncture Needle – Solved by 3-D CT

Researchers describe the loss and internal migration of an acupuncture needle, and its recovery using 3-dimensional reconstruction computed tomography (CT), in the July issue of Gastroenterology. An-qi He et al, report the case of a 62-year-old woman in China who presented with abdominal pain in the left lower quadrant. Her “needle-like abdominal

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  • Do More People Have Celiac Disease in the North vs the South?

Do More People Have Celiac Disease in the North vs the South?

A higher proportion of persons living at latitudes of 35° North or greater have celiac disease or avoid gluten than persons living south of this latitude, researchers report in the June issue of Gastroenterology. This difference was independent of race or ethnicity, socioeconomic status, or body mass index. Several autoimmune

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Gastrointestinal Bleeding Caused by Gastric Tuberculosis

Researchers describe a case of gastric tuberculosis that led to GI bleeding in the June issue of Clinical Gastroenterology and Hepatology. Vishal Sharma et al report that a 30-year-old man who was a resident of North India presented to emergency services with 2 episodes of painless hematemesis. He did not have a history of

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  • FUSE Outperforms Forward-viewing Colonoscopy in Detecting Dysplasia in Patients With IBD

FUSE Outperforms Forward-viewing Colonoscopy in Detecting Dysplasia in Patients With IBD

The panoramic views obtained with full-spectrum endoscopy (FUSE) increase the number of dysplastic lesions detected in the colon, compared with conventional forward-viewing colonoscopy, researchers report in the May issue of Gastroenterology. Inflammatory bowel diseases (IBDs) increase the risk of colorectal cancer. Surveillance colonoscopy with chromoendoscopy is recommended, but conventional forward-viewing colonoscopy

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  • What Factors Associate With Symptom Recurrence After Anti-reflux Surgery for GERD?

What Factors Associate With Symptom Recurrence After Anti-reflux Surgery for GERD?

The most reliable factors associated with symptom recurrence after anti-reflux surgery for patients with gastroesophageal reflux disease (GERD) are a primary complaint of extraesophageal reflux symptoms and lack preoperative response to acid-suppression therapy, researchers report in the May issue of Clinical Gastroenterology and Hepatology. Approximately 10% of the US population has

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  • Gastroduodenal Metastases from Melanoma

Gastroduodenal Metastases from Melanoma

Researchers describe a case of gastroduodenal metastases from cutaneous melanoma, in the May issue of Gastroenterology. Inês Pita et al present the case of a 76-year-old man who arrived at the emergency department with exertional dyspnea and melena for the past 3 weeks, and an episode of presyncope. He denied orthopnea, paroxysmal nocturnal dyspnea,

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  • Does Good Oral Health Increase Risk for IBD?

Does Good Oral Health Increase Risk for IBD?

A population-based cohort study of more than 20,000 people in Sweden associated poor oral health with reduced risk for inflammatory bowel diseases (IBD). The article, in the April issue of Clinical Gastroenterology and Hepatology, reports that the protective effect increases with the severity of poor dental hygiene. Environmental factors, such as

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  • What Causes Wheat Sensitivity in People Without Celiac Disease?

What Causes Wheat Sensitivity in People Without Celiac Disease?

Gluten-containing cereals have high concentrations of amylase-trypsin inhibitors (ATIs), which activate innate immunity via the toll-like receptor 4 (TLR4), researchers report in the April issue of Gastroenterology. These ATIs are resistant to proteases and heat, and increase intestinal inflammation by activating intestinal and mesenteric lymph node myeloid cells. Wheat is

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