GI Tract
  • Model: Microfabricated Crypt Scaffolds for Studying Human Colon Stem Cells

Model: Microfabricated Crypt Scaffolds for Studying Human Colon Stem Cells

Researchers created an in vitro human colon crypt array that provides an accurate representation of human intestinal crypts, reported in the February issue of Cellular and Molecular Gastroenterology and Hepatology. This system re-creates an intestinal epithelium with a high density of polarized crypts that respond in a physiologic manner to growth factors, metabolites, or

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  • Are Patients With PSC and Colitis More likely to Have Subclinical Inflammation?

Are Patients With PSC and Colitis More likely to Have Subclinical Inflammation?

Patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) in remission are significantly more likely to have inflammation of the right colon, based on endoscopic and histologic markers, than patients with UC without PSC, researchers report in the January issue of Clinical Gastroenterology and Hepatology. These findings provide insight into cause

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Video: Prick Test to Identify Allergens That Cause Esophageal Sensitization

An esophageal prick test, in which allergens are injected directly into the esophageal mucosa, appears to identify individuals with esophageal sensitization, researchers report in the January issue of Gastroenterology. In patients with eosinophilic esophagitis (EoE), food allergens are believed to induce an inflammatory response that can make swallowing and eating a challenge. Identifying and

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  • What Happens in the Intestine in Patients With Wilson Disease?

What Happens in the Intestine in Patients With Wilson Disease?

ATP7B regulates vesicular storage of copper and buffers its levels in enterocytes to maintain a range necessary for formation of lipid-transporting vesicles, researchers report in the January issue of Gastroenterology. The authors show that a misbalance of copper and lipid in the intestine could account for gastrointestinal manifestations of Wilson

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  • Does Immunomodulator Therapy for IBD During Pregnancy Affect Newborn Response to Vaccines?

Does Immunomodulator Therapy for IBD During Pregnancy Affect Newborn Response to Vaccines?

Rates of adequate serologic response to Haemophilus influenzae B (HiB) and tetanus vaccines are similar among infants born to women with inflammatory bowel diseases (IBD) treated with immunomodulator or biologic agents compared to women who did not receive these immunosuppressive drugs during pregnancy, researchers report in the January issue of Clinical Gastroenterology

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  • Which Patients With Flat Low-grade Dysplasia are at High Risk for Colorectal Cancer?

Which Patients With Flat Low-grade Dysplasia are at High Risk for Colorectal Cancer?

Detection of flat low-grade dysplasia (fLGD) and aneuploidy in colon tissues increases risk for high-grade dysplaisa (HGD) or colorectal cancer (CRC) more than 5-fold in patients with inflammatory bowel disease (IBD), researchers report in the December issue of Gastroenterology. Aneuploidy was also detected in almost all cases of flat HGD (fHGD) IBD is a risk

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  • Review: Pathogenesis and Prevention of Gastric Cancer

Review: Pathogenesis and Prevention of Gastric Cancer

New diagnostic protocols, effective medical treatments, and recently developed conservative ablative procedures could make gastric cancer a preventable malignancy, says a review article in the December issue of Clinical Gastroenterology and Hepatology. Gastric cancer is 1 of the 5 most common causes of cancer death, and only 30% of patients survive 5

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  • Can Learning to Control Thoracic Muscle Activity Reduce Abdominal Distension?

Can Learning to Control Thoracic Muscle Activity Reduce Abdominal Distension?

A behavioral intervention designed to increase the postural tone of the abdomino-thoracic wall is effective treatment for abdominal distention of no detectable cause, researchers report in a randomized controlled trial published in the December issue of Clinical Gastroeneterology and Hepatology. Abdominal distension is one of the most common complaints among patients seeking

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  • Does Enhanced Sterilization of Duodenoscopes Reduce Contamination?

Does Enhanced Sterilization of Duodenoscopes Reduce Contamination?

A comparison of duodenoscopes reprocessed by standard high-level disinfection (sHLD) vs double high-level disinfection (dHLD) and standard high-level disinfection followed by ethylene oxide gas sterilization (HLD–ETO) found no significant differences in contamination with multidrug-resistant organisms (MRDO) or other bacteria. The article, published in the October issue of Gastroenterology, concludes that enhanced disinfection

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  • Hookworms Cause GI Bleeding

Hookworms Cause GI Bleeding

Hookworms, although uncommon, are an important cause of gastrointestinal bleeding in patients of all ages, researchers remind readers in the November issue of Clinical Gastroenterology and Hepatology. Puneet Chhabra and Deepak K. Bhasin describe the case of a 72-year-old man with Parkinson disease who presented with fatigue, dyspnea on exertion, and

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