GI Tract
  • What Causes Wheat Sensitivity in People Without Celiac Disease?

What Causes Wheat Sensitivity in People Without Celiac Disease?

Gluten-containing cereals have high concentrations of amylase-trypsin inhibitors (ATIs), which activate innate immunity via the toll-like receptor 4 (TLR4), researchers report in the April issue of Gastroenterology. These ATIs are resistant to proteases and heat, and increase intestinal inflammation by activating intestinal and mesenteric lymph node myeloid cells. Wheat is

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  • Efficacy of Endoscopic Sleeve Gastroplasty In Reducing Body Weight and Metabolic Complications

Efficacy of Endoscopic Sleeve Gastroplasty In Reducing Body Weight and Metabolic Complications

Endoscopic sleeve gastroplasty (ESG) sustains loss of total body weight for up to 24 months, and also reduces markers of hypertension, diabetes, and hypertriglyceridemia, researchers report from a prospective study published in the April issue of Clinical Gastroenterology and Hepatology. ESG is an incisionless, minimally invasive bariatric procedure that reduces the

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  • What is the Incidence of Achalasia?

What is the Incidence of Achalasia?

The incidence of achalasia is at least twice as high as previously believed, 2 studies (one from Chicago, the other from Australia) show in the March issue of Clinical Gastroenterology and Hepatology. Achalasia is characterized by dysphagia, regurgitation of undigested food, and chest pain. Patients lose weight due to the

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  • What is the Active Ingredient in FMT for CDI?

What is the Active Ingredient in FMT for CDI?

Sterile fecal filtrates—containing bacterial debris, proteins, antimicrobial compounds, metabolic products, and microbial DNA, rather than intact microorganisms—appear to be effective for treatment of recurrent Clostridium difficile infection (CDI), researchers report in the March issue of Gastroenterology. Fecal microbiota transplantation (FMT) is an effective therapy of recurrent CDI—a single treatment resolves

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  • A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease
  • A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease

A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease

A man with sickle cell disease with generalized pain and progressive jaundice originally thought to have cholangiocarcinoma was eventually found to have Rosai-Dorfman disease, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Arian Teymoorian et al describe the case of a 38-year-old black man with a history of

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Is it Safe to Undergo Endoscopy During Pregnancy?

Endoscopy during pregnancy is associated with slight increases in risk of preterm birth and small for gestational age, but not congenital malformation or stillbirth, researchers report in a nationwide population-based cohort study published in the February issue of Gastroenterology. However, the authors believe the small increase in risk to be

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  • Can Vitamin D Affect Risk of Ulcerative Colitis Relapse?

Can Vitamin D Affect Risk of Ulcerative Colitis Relapse?

Serum levels of vitamin D of 35 ng/mL or less in patients with ulcerative colitis (UC) in clinical remission are associated with disease relapse, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Increasing patients’ levels of vitamin D might reduce their risk for UC relapse. Vitamin D

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  • Video: Screening Breath Compounds to Identify Patients With Barrett’s Esophagus

Video: Screening Breath Compounds to Identify Patients With Barrett’s Esophagus

Researchers can identify patients with Barrett’s esophagus (BE) based on profiles of exhaled volatile organic compounds measured with an electronic nose device. This tool, described in the January issue of Gastroenterology, provides a portable, accessible, and widely acceptable tool for screening and surveillance for BE in patients with gastroesophageal reflux

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  • A Minimally Invasive Endoscopic Procedure Instead of Bariatric Surgery?

A Minimally Invasive Endoscopic Procedure Instead of Bariatric Surgery?

Endoscopic sleeve gastroplasty (ESG) delays gastric emptying, induces early satiation, and significantly reduces body weight, researchers report in the January issue of Clinical Gastroenterology and Hepatology. ESG could therefore be an alternative to bariatric surgery for some patients with obesity. Although bariatric surgery is the most effective therapy for obesity,

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  • Hepatosplenic Lesions from Cat Scratch Disease

Hepatosplenic Lesions from Cat Scratch Disease

Researchers describe an unusual case of cat scratch disease, with hepatosplenic involvement, in the January 2017 issue of Clinical Gastroenterology and Hepatology. Sean K. Verma et al report on a 28-year-old man with no past medical history presented with fevers, chills, abdominal pain, night sweats, 3 weeks of weight loss,

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