GI Tract

IBD Risk Beyond the Bowel

Venous thromboembolism (VTE) is a recurring problem for patients with inflammatory bowel disease (IBD), according to a clinical study by Gottfried Novacek et al. in this month’s issue of Gastroenterology. People with IBD have a high risk for developing blood clots, but it is not clear if they should receive

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Reflux and Laryngitis—a Complicated Relationship

Results from a large clinical trial show that proton pump inhibitors relieve some, but not all the symptoms of chronic laryngitis. One type of laryngitis, laryngopharyngeal reflux (LPR), is characterized by hoarseness, chronic cough, frequent throat clearing, and the feeling of something in the throat. Because it is believed to

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New Word on GERD?

Proton pump inhibitors (PPIs) are useful for treating gastroesophageal reflux disease (GERD), although heartburn completely resolves in only 40% of patients that take these drugs. Furthermore, long-term use of PPIs can increase risk for pneumonia, Clostridium difficile infection, and bone disorders, so other therapeutic strategies are needed. In the August

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Curbing Crohn’s for the Long Term?

Most people with Crohn’s disease receive surgery, yet the disease comes back a short time later. A study in the July issue of Clinical Gastroenterology and Hepatology reports that giving patients low doses of infliximab immediately after surgery prevents disease recurrence over long time periods. Dario Sorrentino et al. began

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Does Polyp Size Matter?

Computed tomography colonography (CTC) is a useful tool for colon cancer screening. The challenge, however, is determining which lesions are most dangerous—should some be treated aggressively and others just monitored or ignored? Does size matter? In the July issue of Clinical Gastroenterology and Hepatology, Perry Pickhardt et al. assessed the

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H. pylori—What Makes It a Friend or Foe in Cancer Risk?

How does infection with Helicobacter pylori (H. pylori) increase risk for gastric cancer but reduce risk for esophageal cancers? One proposed mechanism is that H. pylori induces gastric atrophy and hypochlorhydria—these promote gastric cancer but reduce acid exposure to the lower esophagus, which protects against esophageal adenocarcinoma. However, many people

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Welcome to The AGA Journals Blog

Welcome to “The AGA Journals Blog”—a forum for discussion of the latest discoveries in the fields of gastroenterology and hepatology. Each week we will comment on a new article from the American Gastroenterological Association (AGA) journals Gastroenterology and Clinical Gastroenterology and Hepatology (CGH). The goals for the blog are two-fold:

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