GI Tract

Origins of Gastric Cancer

Gastric tumors can arise from a single mutation in a single stomach gland, according to Lydia Gutierrez-Gonzalez et al. in the April issue of Gastroenterology. To study how gastric dysplasias form and expand, Gutierrez-Gonzalez et al. analyzed 23 samples of gastric epithelium from patients who received surgery for gastric adenocarcinoma

Read more

Cleaning for Colonoscopy

GoLytely better prepares the colon for screening colonoscopy than MiraLAX, report Michael Hjelkrem et al. in the April issue of Clinical Gastroenterology and Hepatology. Efficient cleansing of the colon is one of the most important factors for successful colonscopy examination, but also a major reason that patients avoid screening—because of

Read more

Anti-Inflammatory Drugs Prevent Colorectal Cancer (for Some)

Aspirin and other anti-inflammatory drugs prevent colorectal cancer (CRC) in some people but not others, according to the March issue of Gastroenterology. Andrew Chan et al. found that these drugs reduce the risk of CRC only in women with high levels of soluble tumor necrosis factor receptor 2 (sTNFR-2), a

Read more

What Causes Weight Gain After Gastric Bypass?

A surgical complication, rather than eating habits, can cause patients to regain lost weight after gastric bypass surgery, reports Barham K. Abu Dayyeh et al. in the March issue of Clinical Gastroenterology and Hepatology. The authors correlated increased diameter of the gastrojejunal stoma with long-term weight gain after this common

Read more

IBD Guardian

Researchers have identified a molecule that protects colon cells from injury in a mouse model of inflammatory bowel disease (IBD). The study, published by Beth McConnell et al. in the February issue of Gastroenterology, reports that Klf5 controls genes that mediate recovery from colonic injury. Klf5 regulates transcription of genes

Read more

Safe Bread for Celiacs

Baked goods made from fully hydrolyzed wheat flour, manufactured with sourdough lactobacilli and fungal proteases, are safe for patients with celiac disease, according to the January issue of Clinical Gastroenterology and Hepatology. Celiac disease is caused by an inflammatory response to wheat gluten. Luigi Greco et al. gave patients with celiac

Read more

Colorectal Cancer in Cowden Syndrome

Patients with Cowden syndrome (CS) are at high risk for early-onset colorectal cancer, according to the December issue of Gastroenterology. CS is caused by mutations in the tumor suppressor gene phosphatase and tensin homolog (PTEN). Patients typically have mucocutaneous lesions, large-sized heads, and increased risk for breast, thyroid, and endometrial

Read more

Relief from Irritable Bowel Syndrome

Patients with irritable bowel syndrome (IBS) had significant improvements in bowel habits and reductions in abdominal pain after taking a new drug called linaclotide, reports a study published in the December issue of Gastroenterology. Jeffrey M. Johnston et al. performed a placebo-controlled phase 2 trial of 4 different doses of

Read more

Skin Problems from IBD Therapy?

Recurring and intense skin lesions cause one-third of patients that take anti-tumor necrosis factor (TNF) therapy for inflammatory bowel disease (IBD) to discontinue treatment, reports Jean–François Rahier et al. in the December issue of Clinical Gastroenterology and Hepatology. Anti-TNF agents are used to treat patients with a variety of immune

Read more

Eating Away at Crohn’s Disease

Genetic features of many patients with Crohn’s disease affect the ability of their intestinal cells to undergo autophagy—a form of self-digestion that allows them to fight pathogenic bacteria, according to a study by Craig Homer et al. in the November issue of Gastroenterology. Crohn’s disease is believed to be caused

Read more