GI Tract
  • How Could the Intestinal Microbiota Contribute to Celiac Disease?

How Could the Intestinal Microbiota Contribute to Celiac Disease?

Bacteria in the small intestine metabolize gluten differently, to increase or decrease its immunogenicity, researchers report in the October issue of Gastroenterology. This interaction between microbes and gluten could help determine the risk for autoimmune enteropathy in genetically susceptible individuals and underlie the reported association between dysbiosis and celiac disease.

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  • Candy Cane Esophagus From Hot Tea

Candy Cane Esophagus From Hot Tea

Researchers describe a patient with a “candy cane appearance” of the esophagus, due to acute thermal injury, in the October issue of Clinical Gastroenterology and Hepatology. Upon further investigation, the authors found that the patient had poured hot boiling tea into his throat. Arun AC and Jenish Rajma describe the case of a 19-year-old

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  • Can Disruption of the Intestinal Epithelial Barrier Contribute to Steatohepatitis?

Can Disruption of the Intestinal Epithelial Barrier Contribute to Steatohepatitis?

Mice with defects in intestinal epithelial permeability develop more severe steatohepatitis when placed on a diet high in saturated fat, fructose, and cholesterol (HFCD) than control mice, and colon tissues from patients with non-alcoholic fatty liver disease (NAFLD) have similar defects in intestinal epithelial permeability, researchers report in the October

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  • CMGH now Searchable in PubMed!

CMGH now Searchable in PubMed!

Cellular and Molecular Gastroenterology and Hepatology (CMGH), published by the American Gastroenterological Association, has been accepted for indexing in PubMed Central, which will make all CMGH articles, starting with Volume 1, Issue 1, searchable as full text in PubMed over the next several weeks. In an editorial written for the September

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  • Does Pancreatectomy With Islet Autotransplantation Benefit Patients With Recurrent Acute Pancreatitis?

Does Pancreatectomy With Islet Autotransplantation Benefit Patients With Recurrent Acute Pancreatitis?

In patients with recurrent acute pancreatitis, total pancreatectomy with islet autotransplantation (TPIAT) reduces pain and requirements for narcotic therapy, and increases quality of life, researchers report in the September issue of Clinical Gastroenterology and Hepatology. This treatment should be considered when medical and endoscopic therapies have failed. Recurrent acute pancreatitis, caused

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  • A Forward Genetic Screen Identifies Suppressors of Hepatocellular Carcinogenesis

A Forward Genetic Screen Identifies Suppressors of Hepatocellular Carcinogenesis

Using 2 powerful high-throughput in vivo screening tools, researchers identified and validated 27 genes as suppressors of hepatocellular carcinoma (HCC), reported in the August issue of Gastroenterology. Their findings support the role of Ras signaling in development of HCC and provide new therapeutic targets. Sorafenib is the only treatment for patients

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  • Is Dietary Fiber OK for Patients With Crohn’s Disease or Ulcerative Colitis?

Is Dietary Fiber OK for Patients With Crohn’s Disease or Ulcerative Colitis?

Intake of dietary fiber reduces risk of disease flares in patients with Crohn’s disease, but not ulcerative colitis, researchers report in the August issue of Clinical Gastroenterology and Hepatology. Recommendations to limit dietary fiber should therefore be re-evaluated. Inflammatory bowel diseases (IBD) have been associated with an abnormal mucosal immune response to

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  • Video Abstract: Pros and Cons of Continued Aspirin Use in Patients with Lower GI Bleeding

Video Abstract: Pros and Cons of Continued Aspirin Use in Patients with Lower GI Bleeding

In aspirin users with a history of lower gastrointestinal bleeding, continued aspirin use increases risk of recurrent bleeding by almost 3-fold, but reduces risk of serious cardiovascular events by 40% and risk of death from other causes by 17%, researchers report in the August issue of Gastroenterology. First author Francis K.L. Chan discusses the group’s

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  • Can Microbial Dysbiosis Cause Colonic Inflammation?

Can Microbial Dysbiosis Cause Colonic Inflammation?

Dysbiosis contributes to the pathogenesis of inflammatory bowel diseases (IBD) by altering colonic expression of genes that regulate inflammation and the immune response, researchers report in the July issue of Cellular and Molecular Gastroenterology and Hepatology. An altered intestinal microbiota composition has been associated with IBD. However, it is not

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What Happens to Infants Whose Mothers Took Anti-TNF Agents During Pregnancy?

Anti-tumor necrosis factor (TNF) agents can be detected in infants born to mothers with inflammatory bowel diseases (IBD) who took the drugs during pregnancy, researchers report in the July issue of Gastroenterology. Infliximab is cleared more slowly than adalimumab from infants. However, measureable levels in infants do not seem to be

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