Liver/Biliary
  • Which Patients Are at Greatest Risk From Mushroom Poisoning?

Which Patients Are at Greatest Risk From Mushroom Poisoning?

Almost 20% of patients with liver damage from mushroom (Amanita) poisoning and peak levels of total bilirubin greater than 2 mg/dL require liver transplantation or die, researchers report in the May issue of Clinical Gastroenterology and Hepatology. The authors show that peak level of aspartate aminotransferase (AST) below 4000 IU/L identifies

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  • What are the Effects of Prednisolone in Patients With Severe Alcoholic Liver Disease?

What are the Effects of Prednisolone in Patients With Severe Alcoholic Liver Disease?

Infections are frequent in patients with severe alcoholic liver disease, but are only independently associated with mortality when patients receive prednisolone, researchers report in the April issue of Gastroenterology. This could offset prednisolone’s therapeutic benefit. This study’s senior author, Mark Thursz, discusses the findings in a video abstract. As with

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  • Hemosuccus Pancreaticus Caused by a Pancreatic Tumor

Hemosuccus Pancreaticus Caused by a Pancreatic Tumor

Researchers describe a rare cause of hemosuccus pancreaticus in a patient with pancreatic cancer. The gastrointestinal bleeding was caused by erosion of pancreatic adenocarcinoma into the colon, they show in the April issue of Clinical Gastroenterology and Hepatology. Hemosuccus pancreaticus is defined as hemorrhage from the ampulla of Vater via the pancreatic

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  • What are the Different Types of Liver Cancer, and How do They Develop?

What are the Different Types of Liver Cancer, and How do They Develop?

A review article in the March issue of Gastroenterology discusses different hypotheses about the cells responsible for liver tumorigenesis. The article also reviews the different classes of liver tumors, based on the molecular features, and how these affect patient prognosis. Daniela Sia et al describe the distinct molecular and clinical features of hepatocellular

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  • A New Pathway for Transmitting HBV DNA?

A New Pathway for Transmitting HBV DNA?

Extracellular vesicles carry HBV DNA as cargo that can be transmitted to other hepatocytes, researchers report in the March issue of Cellular and Molecular Gastroenterology and Hepatology. Their findings identify an antibody-neutralization–resistant route of HBV infection. Approximately 350 million people are chronically infected by HBV worldwide, and some of these

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  • A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease
  • A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease

A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease

A man with sickle cell disease with generalized pain and progressive jaundice originally thought to have cholangiocarcinoma was eventually found to have Rosai-Dorfman disease, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Arian Teymoorian et al describe the case of a 38-year-old black man with a history of

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  • What are the Most Accurate Non-invasive Techniques for Measuring Liver Fibrosis and Steatosis?

What are the Most Accurate Non-invasive Techniques for Measuring Liver Fibrosis and Steatosis?

Magnetic resonance elastography (MRE) is more accurate than transient elastography (TE) in identifying liver fibrosis of stage 1 or more, researchers report in the February issue of Gastroenterology, using biopsy analysis as the standard. They also show that MRI-based proton density fat fraction (MRI-PDFF) analysis is more accurate than TE-based

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  • How Can We Study Genetic Heterogeneity Within Hepatocellular Carcinomas?

How Can We Study Genetic Heterogeneity Within Hepatocellular Carcinomas?

Researchers have developed a patient-derived cell line-based model to study how intratumor heterogeneity affects sensitivity of hepatocellular carcinoma (HCC) to different therapeutic agents, reported in the January issue of Gastroenterology. HCCs have a large amount of genetic heterogeneity within each tumor, making them difficult to treat. Multiple regions of tumors

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  • Hepatosplenic Lesions from Cat Scratch Disease

Hepatosplenic Lesions from Cat Scratch Disease

Researchers describe an unusual case of cat scratch disease, with hepatosplenic involvement, in the January 2017 issue of Clinical Gastroenterology and Hepatology. Sean K. Verma et al report on a 28-year-old man with no past medical history presented with fevers, chills, abdominal pain, night sweats, 3 weeks of weight loss,

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  • Why do Pancreatic Tumor Cells Love the Liver?

Why do Pancreatic Tumor Cells Love the Liver?

Pancreatic ductal adenocarcinoma (PDAC) and its precursors secrete high levels of tissue inhibitor of metalloproteinases 1 (TIMP1) into the circulation, which activates hepatic stellate cells (HSCs) in liver. These cells help create a niche that promotes metastasis of pancreatic tumors to liver, researchers report in the November issue of Gastroenterology.

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