Liver/Biliary
  • 500 Posts by the AGA Journals Blog

500 Posts by the AGA Journals Blog

This week the AGA Journals Blog has reached an important milestone — its 500th post! The blog was started in 2010 to help disseminate the important discoveries published in the AGA Journals to a broader audience. Eight years and over 132,000 views later, it has updated its readers on everything from biomarkers for colon

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  • A Genetic Cause for Multiple Adenomas and Diabetes in a Young Patient

A Genetic Cause for Multiple Adenomas and Diabetes in a Young Patient

Researchers report a case of a patient with multiple adenomas and a family history of young-onset diabetes and hepatocellular carcinoma. They found these to be caused by a mutation in the HNF1 homeobox A gene (HNF1A), which caused maturity onset diabetes of the young type 3 (MODY3). Tom J. Harryvan et al evaluated a

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  • What are the Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis?

What are the Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis?

Vitamin K antagonists (VKAs) increase risk of minor bleeding in patients with cirrhosis given anticoagulants for portal vein thrombosis (PVT), compared to patients without cirrhosis given VKAs, researchers report in the July issue of Clinical Gastroenterology and Hepatology. However, this risk is offset by the ability of VKA to increase portal

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  • Can Nonlytic T cells be Engineered to Fight HBV Infection?

Can Nonlytic T cells be Engineered to Fight HBV Infection?

Nonlytic T cells with receptors engineered to recognize HBV suppress virus replication in hepatocytes and limit infection of mice by activating APOBEC3, researchers report in the July issue of Gastroenterology. These cells are not hepatotoxic and might be developed for treatment of chronic HBV infection. T cells control chronic viral infections, and virus-specific

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  • What are the Challenges to In Vitro Maturation of Hepatic Stem Cells?

What are the Challenges to In Vitro Maturation of Hepatic Stem Cells?

New approaches are needed to generate and maintain stable and mature adult liver cells ex vivo. In the April issue of Gastroenterology, Bart Spee and colleagues review factors that promote hepatocyte differentiation and maturation, and consider criteria for establishing whether cells derived from stem cells are fully mature hepatocytes. They discuss challenges to cell transplantation and

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  • Does Pioglitazone Have the Same Effects on NASH in Patients With vs Without Diabetes?

Does Pioglitazone Have the Same Effects on NASH in Patients With vs Without Diabetes?

Patients with prediabetes and nonalcoholic steatohepatitis (NASH) benefit nearly as much from pioglitazone therapy as those with type-2 diabetes, researchers report in the April issue of Clinical Gastroenterology and Hepatology. The diabetes drug reduced fibrosis in non-diabetic patients with NASH, the clinical study found, although to a lesser extent than in patients

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  • Why is Gallbladder Cancer Mortality Decreasing in Some Countries but Increasing in Others?

Why is Gallbladder Cancer Mortality Decreasing in Some Countries but Increasing in Others?

Deaths from gallbladder and other biliary tract cancers are decreasing in most countries, but increasing in some high-income countries following decades of decline, researchers report in the March issue of Clinical Gastroenterology and Hepatology. These emerging trends may reflect lifestyle changes, such as increases in excess body weight. Gallbladder cancer is

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  • Developing a New Combination Treatment for HBV Infection

Developing a New Combination Treatment for HBV Infection

NVR3–778, a capsid assembly modulator, reduces serum levels of hepatitis B virus (HBV) DNA and HBV RNA in mice with humanized livers and stable HBV infection, researchers report in the February issue of Gastroenterology. The combination of NVR3–778 and interferon prevented viral replication and HBV RNA particle production to a greater extent than

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  • Review: Diagnosis, Pathogenesis, and Treatment of Hepatorenal Syndrome in Patients With Cirrhosis

Review: Diagnosis, Pathogenesis, and Treatment of Hepatorenal Syndrome in Patients With Cirrhosis

Hepatorenal syndrome (HRS), a frequently fatal complication of decompensated cirrhosis, is difficult to evaluate due to challenges in assessment of glomerular filtration rate and level of renal dysfunction. In the February issue of Clinical Gastroenterology and Hepatology Ayse L. Mindikoglu and Stephen C. Pappas review strategies for diagnosis and assessment of renal function in patients with

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  • What Complications Can Arise From Percutaneous Liver Biopsy?

What Complications Can Arise From Percutaneous Liver Biopsy?

A unique complication of portal vein thrombosis after a percutaneous liver biopsy is reported in the January issue of Clinical Gastroenterology and Hepatology. Liver biopsies are collected to aid in diagnosis of liver disease and staging of fibrosis, but complications can include pain, bleeding, puncture of another organ, and rare events such as biliary peritonitis, sepsis and

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