Liver/Biliary
  • Does an SVR to Therapy for HCV-associated Cirrhosis Reduce Portal Pressure?

Does an SVR to Therapy for HCV-associated Cirrhosis Reduce Portal Pressure?

A sustained virologic response (SVR) to all-oral therapy in patients with hepatitis C virus (HCV)-associated cirrhosis significantly reduces the hepatic venous pressure gradient (HVPG), researchers report in the November issue of Gastroenterology. Nevertheless, almost 80% of patients maintain significant portal hypertension and have a continued risk of decompensation. In patients with compensated

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  • How Could Lamins Protect Against Steatohepatitis?

How Could Lamins Protect Against Steatohepatitis?

Lamin A/C acts maintains hepatocyte nuclear shape and protects male mice from steatohepatitis by regulating growth hormone signaling and reducing activity of STAT1, researchers report in the November issue of Cellular and Molecular Gastroenterology and Hepatology. These observations show how variants in genes encoding lamins affect risk for steatohepatitis and liver fibrosis. Lamins are nuclear intermediate filament proteins that help form

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  • Special 15th Anniversary Collection from CGH

Special 15th Anniversary Collection from CGH

Clinical Gastroenterology and Hepatology (CGH) proudly presents a special collection to celebrate the journal’s 15th year of publication. This collection comprises landmark articles chosen by the CGH Board of Editors for their contributions to science and the practice of gastroenterology and hepatology. The 15th anniversary collection includes commentaries from authors on select groundbreaking original research articles. In these, authors

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  • Can Restricting Fructose Intake Reduce Fatty Liver Disease in Children?

Can Restricting Fructose Intake Reduce Fatty Liver Disease in Children?

Reducing dietary fructose for as little as 9 days decreases liver fat, visceral fat, and de novo lipogenesis and increases insulin sensitivity, secretion, and clearance in children with obesity and metabolic syndrome, researchers report in the September issue of Gastroenterology. These findings support efforts to reduce sugar consumption. Consumption of sugar

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  • Can Exposure to Aflatoxin Cause Gallbladder Cancer?

Can Exposure to Aflatoxin Cause Gallbladder Cancer?

Exposure to aflatoxin increases risk of gallbladder cancer, researchers report in the September issue of Gastroenterology. Ingestion of aflatoxin, produced by a fungi that grows on corn and peanuts, could account for the high incidence of gallbladder cancers in some regions of China and Chile. Gallbladder cancer, the most common biliary tract cancer, has

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  • What is the Best Management Strategy for Patients With NAFLD?

What is the Best Management Strategy for Patients With NAFLD?

Management of patients with non-alcoholic fatty liver disease (NAFLD) requires combined efforts of general practitioners, hepatologists, and other experts, Herbert Tilg explains in a Mentoring, Education, and Training Corner article in the August issue of Gastroenterology. NAFLD has become the most common liver disease worldwide. It ranges from simple steatosis in the absence

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  • FISH and Mutations Best Identify Biliary Stricture Malignancies

FISH and Mutations Best Identify Biliary Stricture Malignancies

Addition of fluorescence in situ hybridization (FISH) and mutation analyses to cytology analysis significantly increases the sensitivity of detection of malignancies in biliary strictures, researchers report in the June issue of Clinical Gastroenterology and Hepatology. These techniques can be performed using standard brush samples collected during endoscopic retrograde cholangiopancreatography, with mutations detected in

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  • Bioinformatic Search Identifies Tapeworm Drug for Treatment of Hepatocellular Carcinoma

Bioinformatic Search Identifies Tapeworm Drug for Treatment of Hepatocellular Carcinoma

In a bioinformatic search for agents that alter the hepatocellular carcinoma (HCC)-specific gene expression pattern, researchers identified the anthelmintic drug niclosamide as a potential anti-tumor agent, described in the June issue of Gastroenterology. Niclosamide and its ethanolamine salt (NEN), with greater bioavailability, slowed growth of genetically induced liver tumors and

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  • Which Patients Are at Greatest Risk From Mushroom Poisoning?

Which Patients Are at Greatest Risk From Mushroom Poisoning?

Almost 20% of patients with liver damage from mushroom (Amanita) poisoning and peak levels of total bilirubin greater than 2 mg/dL require liver transplantation or die, researchers report in the May issue of Clinical Gastroenterology and Hepatology. The authors show that peak level of aspartate aminotransferase (AST) below 4000 IU/L identifies

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  • What are the Effects of Prednisolone in Patients With Severe Alcoholic Liver Disease?

What are the Effects of Prednisolone in Patients With Severe Alcoholic Liver Disease?

Infections are frequent in patients with severe alcoholic liver disease, but are only independently associated with mortality when patients receive prednisolone, researchers report in the April issue of Gastroenterology. This could offset prednisolone’s therapeutic benefit. This study’s senior author, Mark Thursz, discusses the findings in a video abstract. As with

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