Liver/Biliary
  • Does DAA Therapy for HCV Infection Increase Survival in Patients Who Have Responded to Treatment for Hepatocellular Carcinoma?

Does DAA Therapy for HCV Infection Increase Survival in Patients Who Have Responded to Treatment for Hepatocellular Carcinoma?

In patients who have received successful treatment for HCV-related hepatocellular carcinoma (HCC), eradication of the HCV infection with direct-acting antiviral (DAA) significantly reduces risk of death, researchers report in the November issue of Gastroenterology. Chronic hepatitis C virus (HCV) infection is the most common cause of HCC in North America and Europe. DAA

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  • Does Placement on a Distant Liver Waitlist Increase Chances of Transplantation?

Does Placement on a Distant Liver Waitlist Increase Chances of Transplantation?

Placement on a liver transplant waitlist outside of a patient’s home region can reduce mortality and increase odds of receiving a liver, researchers report in the October issue of Clinical Gastroenterology and Hepatology. Strategies are needed to overcome geographic differences in access to livers for transplantation, which are more likely

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  • How Should We Treat Recurrent Acute Pancreatitis?

How Should We Treat Recurrent Acute Pancreatitis?

Recurrent acute pancreatitis with a clear cause can be treated with endoscopy, explain Liam Zakko and Timothy B. Gardner in a “Here and Now: Clinical Practice” article in the October issue of Clinical Gastroenterology and Hepatology. Acute pancreatitis affects 40 to 50 of every 100,000 Americans per year and is the

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  • How Does Alpha-1 Antitrypsin Deficiency Affect the Liver?

How Does Alpha-1 Antitrypsin Deficiency Affect the Liver?

Adults with a severe form of alpha-1 antitrypsin deficiency (AATD) caused by the Pi*Z mutation, and mice with the same genetic alteration, can have liver steatosis and impaired lipid secretion, researchers report in the September issue of Gastroenterology. The research team found factors associated with significant liver fibrosis in patients

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  • Efficacy and Safety of Besifovir Dipivoxil Maleate in a Phase 3 Trial of Patients With Chronic HBV Infection

Efficacy and Safety of Besifovir Dipivoxil Maleate in a Phase 3 Trial of Patients With Chronic HBV Infection

The efficacy of 48 weeks treatment with besifovir dipivoxil maleate (BSV) for chronic hepatitis B virus (HBV) infection is comparable to that of tenofovir disoproxil fumarate (TDF), with durable effects for 96 weeks, researchers report in the August issue of Clinical Gastroenterology and Hepatology. BSV has a better safety profile

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  • Why Are Patients Cured of HCV Infection Still at Risk for Liver Cancer?

Why Are Patients Cured of HCV Infection Still at Risk for Liver Cancer?

Chronic infection with the hepatitis C virus (HCV) causes epigenetic changes in liver cells that alter gene expression patterns and continue to affect risk for hepatocellular carcinoma (HCC), regardless of patients’ response to direct-activating antiviral (DAA) agents, researchers report in the June issue of Gastroenterology. These alterations might be targeted

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  • Lusutrombopag Reduces Need for Platelet Transfusion in Patients With Thrombocytopenia and Chronic Liver Disease

Lusutrombopag Reduces Need for Platelet Transfusion in Patients With Thrombocytopenia and Chronic Liver Disease

Lusutrombopag, an oral small molecule agonist of the thrombopoietin receptor, achieves and maintains target platelet count in patients with chronic liver disease and thrombocytopenia undergoing invasive procedures, researchers report in a phase 3, placebo-controlled trial published in the May issue of Clinical Gastroenterology and Hepatology. The drug caused no significant

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  • How Does Estrogen Receptor Signaling Promote Growth of Liver Tumors?

How Does Estrogen Receptor Signaling Promote Growth of Liver Tumors?

The G-protein–coupled estrogen receptor (GPER1) is a hepatic sensor of estrogen that regulates liver growth during development, regeneration, and tumorigenesis, researchers show in a study of zebrafish and human liver published in the May issue of Gastroenterology. Inhibitors of GPER1 might be developed for liver cancer prevention or treatment. Liver cancer

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  • Is Bariatric Surgery the Best Treatment for NAFLD?

Is Bariatric Surgery the Best Treatment for NAFLD?

Bariatric surgery completely resolves non-alcoholic fatty liver disease (NAFLD) in obese patients, researchers report in the May issue of Clinical Gastroenterology and Hepatology. However, The meta-analysis also found that some patients develop new or worsened features of NAFLD after these surgical weight-loss procedures. NAFLD is characterized by hepatic steatosis that

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Is an Endoscopic Transluminal Approach Better Than Surgery for Patients With Necrotizing Pancreatitis?

An endoscopic transluminal approach for treatment of infected necrotizing pancreatitis, compared with minimally invasive surgery, significantly reduced major complications, lowered costs, and increased quality of life, according to a randomized trial published in the March issue of Gastroenterology. Acute pancreatitis is the third most common gastrointestinal disorder in the United

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