Liver/Biliary
  • Review: Diagnosis, Pathogenesis, and Treatment of Hepatorenal Syndrome in Patients With Cirrhosis

Review: Diagnosis, Pathogenesis, and Treatment of Hepatorenal Syndrome in Patients With Cirrhosis

Hepatorenal syndrome (HRS), a frequently fatal complication of decompensated cirrhosis, is difficult to evaluate due to challenges in assessment of glomerular filtration rate and level of renal dysfunction. In the February issue of Clinical Gastroenterology and Hepatology Ayse L. Mindikoglu and Stephen C. Pappas review strategies for diagnosis and assessment of renal function in patients with

Read more
  • What Complications Can Arise From Percutaneous Liver Biopsy?

What Complications Can Arise From Percutaneous Liver Biopsy?

A unique complication of portal vein thrombosis after a percutaneous liver biopsy is reported in the January issue of Clinical Gastroenterology and Hepatology. Liver biopsies are collected to aid in diagnosis of liver disease and staging of fibrosis, but complications can include pain, bleeding, puncture of another organ, and rare events such as biliary peritonitis, sepsis and

Read more
  • What Happens in the Intestine in Patients With Wilson Disease?

What Happens in the Intestine in Patients With Wilson Disease?

ATP7B regulates vesicular storage of copper and buffers its levels in enterocytes to maintain a range necessary for formation of lipid-transporting vesicles, researchers report in the January issue of Gastroenterology. The authors show that a misbalance of copper and lipid in the intestine could account for gastrointestinal manifestations of Wilson

Read more
  • Does an SVR to Therapy for HCV-associated Cirrhosis Reduce Portal Pressure?

Does an SVR to Therapy for HCV-associated Cirrhosis Reduce Portal Pressure?

A sustained virologic response (SVR) to all-oral therapy in patients with hepatitis C virus (HCV)-associated cirrhosis significantly reduces the hepatic venous pressure gradient (HVPG), researchers report in the November issue of Gastroenterology. Nevertheless, almost 80% of patients maintain significant portal hypertension and have a continued risk of decompensation. In patients with compensated

Read more
  • How Could Lamins Protect Against Steatohepatitis?

How Could Lamins Protect Against Steatohepatitis?

Lamin A/C acts maintains hepatocyte nuclear shape and protects male mice from steatohepatitis by regulating growth hormone signaling and reducing activity of STAT1, researchers report in the November issue of Cellular and Molecular Gastroenterology and Hepatology. These observations show how variants in genes encoding lamins affect risk for steatohepatitis and liver fibrosis. Lamins are nuclear intermediate filament proteins that help form

Read more
  • Special 15th Anniversary Collection from CGH

Special 15th Anniversary Collection from CGH

Clinical Gastroenterology and Hepatology (CGH) proudly presents a special collection to celebrate the journal’s 15th year of publication. This collection comprises landmark articles chosen by the CGH Board of Editors for their contributions to science and the practice of gastroenterology and hepatology. The 15th anniversary collection includes commentaries from authors on select groundbreaking original research articles. In these, authors

Read more
  • Can Restricting Fructose Intake Reduce Fatty Liver Disease in Children?

Can Restricting Fructose Intake Reduce Fatty Liver Disease in Children?

Reducing dietary fructose for as little as 9 days decreases liver fat, visceral fat, and de novo lipogenesis and increases insulin sensitivity, secretion, and clearance in children with obesity and metabolic syndrome, researchers report in the September issue of Gastroenterology. These findings support efforts to reduce sugar consumption. Consumption of sugar

Read more
  • Can Exposure to Aflatoxin Cause Gallbladder Cancer?

Can Exposure to Aflatoxin Cause Gallbladder Cancer?

Exposure to aflatoxin increases risk of gallbladder cancer, researchers report in the September issue of Gastroenterology. Ingestion of aflatoxin, produced by a fungi that grows on corn and peanuts, could account for the high incidence of gallbladder cancers in some regions of China and Chile. Gallbladder cancer, the most common biliary tract cancer, has

Read more
  • What is the Best Management Strategy for Patients With NAFLD?

What is the Best Management Strategy for Patients With NAFLD?

Management of patients with non-alcoholic fatty liver disease (NAFLD) requires combined efforts of general practitioners, hepatologists, and other experts, Herbert Tilg explains in a Mentoring, Education, and Training Corner article in the August issue of Gastroenterology. NAFLD has become the most common liver disease worldwide. It ranges from simple steatosis in the absence

Read more
  • FISH and Mutations Best Identify Biliary Stricture Malignancies

FISH and Mutations Best Identify Biliary Stricture Malignancies

Addition of fluorescence in situ hybridization (FISH) and mutation analyses to cytology analysis significantly increases the sensitivity of detection of malignancies in biliary strictures, researchers report in the June issue of Clinical Gastroenterology and Hepatology. These techniques can be performed using standard brush samples collected during endoscopic retrograde cholangiopancreatography, with mutations detected in

Read more