Liver/Biliary
  • What is the Most Effective Method for Treating Unresectable Malignant Distal Biliary Obstruction?

What is the Most Effective Method for Treating Unresectable Malignant Distal Biliary Obstruction?

Endoscopic ultrasound-guided biliary drainage (EUS-BD) and percutaneous transhepatic biliary drainage (PTBD) are equally effective in treating patients with unresectable malignant distal biliary obstruction and inaccessible papilla, researchers report in the July issue of Clinical Gastroenterology and Hepatology. However, EUS-BD produced fewer procedure-related adverse events and unscheduled re-interventions. PTBD has been

Read more
  • Gastroenterology Special Isssue on Alcoholic vs Non-Alcoholic Fatty Liver Disease

Gastroenterology Special Isssue on Alcoholic vs Non-Alcoholic Fatty Liver Disease

A special issue of Gastroenterology is devoted to comparing alcoholic vs nonalcoholic fatty liver disease. In an introduction to the issue, Arun Sanyal et al write that alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) have much in common, including histologic features and activation of pathways involved in their pathogenesis. They also have some

Read more
  • How Could Variants in TM6SF2 Affect Risk for NAFLD?

How Could Variants in TM6SF2 Affect Risk for NAFLD?

The human transmembrane 6 superfamily member 2 (TM6SF2) protein regulates cholesterol metabolism in mice, researchers report in the May issue of Gastroenterology. These findings provide insight into the how a variant of TM6SF2 (encoding the amino acid change E167K) reduces total cholesterol and low-density lipoprotein cholesterol (LDL-c) levels in humans, and

Read more
  • Do NSAIDs Prevent PEP?

Do NSAIDs Prevent PEP?

Rectal indomethacin does not prevent pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP), researchers report from a randomized controlled study published in the April issue of Gastroenterology. These findings contradict more than a decade of evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the risk of post-ERCP pancreatitis (PEP). Acute pancreatitis is the

Read more
  • Alcohol Consumption and Fatty Liver—A Double Whammy for Liver Cancer Risk

Alcohol Consumption and Fatty Liver—A Double Whammy for Liver Cancer Risk

High to intermediate levels of ethanol consumption increase the risk for liver cancer in patients with fatty liver disease, researchers report in the April issue of Clinical Gastroenterology and Hepatology. Nonalcoholic fatty liver disease is a common cause of chronic liver disease associated with obesity, dyslipidemia, pituitary dysfunction, hypertension, sleep

Read more
  • Can Nutritional Therapy Help Patients with Minimal Hepatic Encephalopathy?

Can Nutritional Therapy Help Patients with Minimal Hepatic Encephalopathy?

Nutritional therapy for patients with cirrhosis and minimal hepatic encephalopathy (MHE) not only improves their nutritional status, but increases cognitive function, health-related quality of life (HRQOL), and liver function and reduces hospitalization, researchers report in the March issue of Clinical Gastroenterology and Hepatology. HE is a spectrum of neuropsychiatric abnormalities that develops in

Read more

Pancreaticobiliary Maljunction and Neuroendocrine Carcinoma

Researchers describe an unusual case—a patient with a neuroendocrine carcinoma of the gallbladder accompanied by pancreaticobiliary maljunction—in the March issue of Clinical Gastroenterology and Hepatology. Tomonori Matsumoto et al examined a 58-year-old man with epigastric pain. Computed tomography (A) and fluoro-2-deoxy-d-glucose positron emission tomography (B) revealed angular diffuse thickening of the gallbladder

Read more
  • Does a PNPLA3 Polymorphism Promote Fibrosis Progression in Patients with Hepatitis C?

Does a PNPLA3 Polymorphism Promote Fibrosis Progression in Patients with Hepatitis C?

A single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain containing 3 gene (PNPLA3) is associated with baseline level of fibrosis and its progression, but not development of hepatocellular carcinoma (HCC), in patients with hepatitis C virus (HCV) infection, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Most

Read more
  • A Nanoparticle-based Approach to Selectively Target Hepatocellular Carcinomas

A Nanoparticle-based Approach to Selectively Target Hepatocellular Carcinomas

Researchers have created nanoparticles that selectively kill hepatoma cells and reduce growth of liver tumors in rats, they report in the February issue of Gastroenterology. They show that the particles induce tumor-specific necrosis by selectively disrupting redox balance within cancer cells. Dietary intake of the natural omega-3 fatty acid docosahexaenoic

Read more
  • Do Proton Pump Inhibitors Reduce the Need for Phlebotomy in Patients With Hereditary Hemochromatosis?

Do Proton Pump Inhibitors Reduce the Need for Phlebotomy in Patients With Hereditary Hemochromatosis?

In certain patients with hereditary hemochromatosis (HH), treatment with proton pump inhibitors (PPIs) for 2 or more years significantly reduced the number of phlebotomies required to maintain serum levels below 100 μg/L, researchers report in the January issue of Clinical Gastroenterology and Hepatology. HH is one of the most common

Read more