Aryl hydrocarbons in cigarette smoke activate an immune response that promotes pancreatic fibrosis and contributes to pancreatitis, researchers report in the December issue of Gastroenterology. The authors show that constituents of tobacco smoke activate signaling via the aryl hydrocarbon receptor (AHR) to induce T-cell production of interleukin 22 (IL22), activatingRead more
Cellular and Molecular Gastroenterology and Hepatology (CMGH), published by the American Gastroenterological Association, has been accepted for indexing in PubMed Central, which will make all CMGH articles, starting with Volume 1, Issue 1, searchable as full text in PubMed over the next several weeks. In an editorial written for the SeptemberRead more
In pancreatic tumors of mice, radiation causes infiltration by macrophages that acquire an immune-suppressive phenotype that disables T-cell–mediated anti-tumor responses, researchers report in the June issue of Gastroenterology. Blocking colony stimulating factor (CSF1 or MCSF) prevents this process, allowing radiation to slow tumor growth, they show. Most patients with pancreaticRead more
Rectal indomethacin does not prevent pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP), researchers report from a randomized controlled study published in the April issue of Gastroenterology. These findings contradict more than a decade of evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the risk of post-ERCP pancreatitis (PEP). Acute pancreatitis is theRead more
Advances in imaging technologies over the past decades have greatly increased the numbers of pancreatic cysts detected, researchers report in the April issue of Clinical Gastroenterology and Hepatology. With further improvements in pancreatic imaging, more pancreatic cysts are likely to be discovered, so gastroenterologists, surgeons, endoscopic ultrasound specialists, and primaryRead more
Do Proton Pump Inhibitors Reduce the Need for Phlebotomy in Patients With Hereditary Hemochromatosis?
In certain patients with hereditary hemochromatosis (HH), treatment with proton pump inhibitors (PPIs) for 2 or more years significantly reduced the number of phlebotomies required to maintain serum levels below 100 μg/L, researchers report in the January issue of Clinical Gastroenterology and Hepatology. HH is one of the most commonRead more
An orally administered yeast lipase increases digestion of fat in a minipig model of pancreatic exocrine insufficiency (PEI), similar to that of pancreatin used in pancreatic enzyme replacement therapy, researchers report in the December issue of Gastroenterology. Patients with PEI have decreased pancreatic secretion of digestive enzymes such as lipase. ThisRead more