Pancreas
  • How Does Cigarette Smoke Promote Pancreatic Tumor Development?

How Does Cigarette Smoke Promote Pancreatic Tumor Development?

Exposure to cigarette smoke activates stem cell features in pancreatic cells, via nicotinic cholinergic receptor signaling to transcription factors that activate expression of stem cell genes, researchers report in the September issue of Gastroenterology. Levels of the stem cell transcriptional regulator PAF1 are increased in pancreatic tumors from humans and

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  • Hyperglycemia as a Marker for Early Detection of Pancreatic Cancer

Hyperglycemia as a Marker for Early Detection of Pancreatic Cancer

Patients are hyperglycemic for a mean period of 36 to 30 months before a diagnosis of pancreatic ductal adenocarcinoma (PDAC), researchers report in the August issue of Gastroenterology. This information might be used in strategies for early detection. At the time of PDAC diagnosis, approximately 85% of subjects have hyperglycemia

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  • 500 Posts by the AGA Journals Blog

500 Posts by the AGA Journals Blog

This week the AGA Journals Blog has reached an important milestone — its 500th post! The blog was started in 2010 to help disseminate the important discoveries published in the AGA Journals to a broader audience. Eight years and over 132,000 views later, it has updated its readers on everything from biomarkers for colon

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  • Does Acute Pancreatitis Increase Risk of Pancreatic Cancer?

Does Acute Pancreatitis Increase Risk of Pancreatic Cancer?

Patients hospitalized with acute pancreatitis have a 2-fold increased risk of pancreatic cancer compared with the general population, researchers report in the May issue of Gastroenterology. Acute pancreatitis is a sudden-onset inflammatory disease of the pancreas. Although acute pancreatitis promotes development of pancreatic cancer in mouse models, there have been conflicting findings from epidemiology

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  • Review: How Does the Tumor Stroma Contribute to Pancreatic Cancer Progression, and Can We Stop It?

Review: How Does the Tumor Stroma Contribute to Pancreatic Cancer Progression, and Can We Stop It?

Recently developed approaches for reshaping the pancreatic tumor stroma might be used in treatments for pancreatic cancer, according to a review in the March issue of Gastroenterology. The authors discuss relationships among the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and how these might be manipulated to stop pancreatic tumor

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  • VIDEO: Non-invasive Detection of Early- and Late-Stage PDAC

VIDEO: Non-invasive Detection of Early- and Late-Stage PDAC

Specific patterns of volatile organic compounds (VOCs) in urine samples can identify patients with pancreatic ductal adenocarcinoma (PDAC), researchers report in the February issue of Gastroenterology. The noninvasive technology, based on ion mobility spectrometry, can be used to discriminate between healthy individuals vs individuals with early- or advanced-stage cancer. VOCs are metabolic products of microbes that can

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  • Special 15th Anniversary Collection from CGH

Special 15th Anniversary Collection from CGH

Clinical Gastroenterology and Hepatology (CGH) proudly presents a special collection to celebrate the journal’s 15th year of publication. This collection comprises landmark articles chosen by the CGH Board of Editors for their contributions to science and the practice of gastroenterology and hepatology. The 15th anniversary collection includes commentaries from authors on select groundbreaking original research articles. In these, authors

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  • What is the Risk of Pancreatic Cancer in Patients with Low-Risk IPMNs?

What is the Risk of Pancreatic Cancer in Patients with Low-Risk IPMNs?

Low-risk intraductal papillary mucinous neoplasms have an almost 8% chance of progressing to pancreatic cancer within 10 years, whereas higher-risk IPMNs have almost 25% chance, reports a systematic review and meta-analysis in the October issue of Clinical Gastroenterology and Hepatology. Continued long-term surveillance is therefore important for patients with low-risk, as

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  • Can Your Diet Affect Your Risk for Gallstone-related Pancreatitis?

Can Your Diet Affect Your Risk for Gallstone-related Pancreatitis?

Consumption of red meat, saturated fat, and cholesterol increase risk for gallstone-related acute pancreatitis, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Dietary fiber protects against acute pancreatitis—related and unrelated to gallstones—whereas coffee protects against acute pancreatitis not associated with gallstones, the study of thousands of patients

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  • How Does Cigarette Smoking Lead to Chronic Pancreatitis?

How Does Cigarette Smoking Lead to Chronic Pancreatitis?

Aryl hydrocarbons in cigarette smoke activate an immune response that promotes pancreatic fibrosis and contributes to pancreatitis, researchers report in the December issue of Gastroenterology. The authors show that constituents of tobacco smoke activate signaling via the aryl hydrocarbon receptor (AHR) to induce T-cell production of interleukin 22 (IL22), activating

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