Pancreas
  • Can We Use a Yeast Lipase in Enzyme Replacement Therapy for Pancreatic Exocrine Insufficiency?

Can We Use a Yeast Lipase in Enzyme Replacement Therapy for Pancreatic Exocrine Insufficiency?

An orally administered yeast lipase increases digestion of fat in a minipig model of pancreatic exocrine insufficiency (PEI), similar to that of pancreatin used in pancreatic enzyme replacement therapy, researchers report in the December issue of Gastroenterology. Patients with PEI have decreased pancreatic secretion of digestive enzymes such as lipase. This

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  • Who Should Undergo Surgery for Pancreatic Cysts?

Who Should Undergo Surgery for Pancreatic Cysts?

When should a patient with a pancreatic cystic lesion undergo surgery? How can we tell if the surgery will provide relief, or prevent death from pancreatic cancer, or burden a patient with an unnecessary procedure? Two articles in the October issue of Clinical Gastroenterology and Hepatology increase our understanding of

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  • Special Issue: Genetics, Genetic Testing, and Biomarkers of Digestive Diseases

Special Issue: Genetics, Genetic Testing, and Biomarkers of Digestive Diseases

A special issue of Gastroenterology features 14 articles discussing the genetic factors that contribute to a range of gastrointestinal (GI),  hepatobiliary, and pancreatic diseases, and how this information can be used in diagnosis and treatment of patients. An introduction to the special issue explains the value of associating diseases with specific genetic variants, which can help

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  • Should Patients Undergo Endoscopic Sphincterotomy Before Receiving Self-expandable Metallic Stents?

Should Patients Undergo Endoscopic Sphincterotomy Before Receiving Self-expandable Metallic Stents?

Endoscopic sphincterotomy (ES) provides no benefit to patients receiving self-expandable metallic stents (SEMS) for a biliary stricture caused by pancreatic cancer, researchers report in the June issue of Clinical Gastroenterology and Hepatology. The randomized controlled trial showed that ES procedure did not affect number of adverse events, SEMS patency, or

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  • Does Controlling Glycemia Increase Gastric Emptying in Patients with Diabetes?

Does Controlling Glycemia Increase Gastric Emptying in Patients with Diabetes?

Two-thirds of patients with poorly controlled type 2 diabetes have mostly asymptomatic yet abnormal gastric emptying, researchers report in the March issue of Clinical Gastroenterology and Hepatology. However, sustained improvements in glycemic control do not affect gastric emptying, the researchers found in a prospective study. Diabetes is associated with delayed

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  • The Same Path to Pancreatitis From Alcohol Abuse or Cystic Fibrosis?

The Same Path to Pancreatitis From Alcohol Abuse or Cystic Fibrosis?

Excessive alcohol consumption disrupts expression and localization of the cystic fibrosis transmembrane conductance regulator (CFTR), researchers report in the February issue of Gastroenterology. People with loss-of-function mutations in the CFTR develop cystic fibrosis and are at risk for pancreatitis—the finding that alcohol intake also alters this protein could provide insight

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  • How Does Smoking Lead to Pancreatic Cancer?

How Does Smoking Lead to Pancreatic Cancer?

Nicotine promotes pancreatic carcinogenesis by disrupting signaling and transcriptional pathways to cause dedifferentiation of acinar cells, researchers report in the November issue of Gastroenterology. One fourth of all deaths from pancreatic ductal adenocarcinoma (PDAC) are associated with tobacco use, and heavy smoking increases risk for PDAC 6-fold. Although smokers develop PDAC

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How Can We Prevent Pancreatic Disease?

Tobacco use, obesity, and heavy use of alcohol are the factors most likely to increase risk for pancreatic diseases, researchers report in the October issue of Clinical Gastroenterology and Hepatology. Vegetables and fruit, on the other hand, appear to reduce risk. Strategies to prevent acute pancreatitis, chronic pancreatitis, and pancreatic

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  • Measuring MicroRNAs to Detect Pancreatic Cancer

Measuring MicroRNAs to Detect Pancreatic Cancer

Analysis of microRNAs improves cytologic analysis of pancreatic fine-needle aspirates, allowing for more accurate identification of patients with pancreatic ductal adenocarcinoma (PDAC), researchers report in the October issue of Clinical Gastroenterology and Hepatology. This improvement could reduce the number of diagnostic procedures required for patients with pancreatic masses. Endoscopic ultrasound–guided fine-needle

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  • Can we Increase Detection of Duct Abnormalities by MRCP?

Can we Increase Detection of Duct Abnormalities by MRCP?

Administration of secretin improves noninvasive imaging of pancreatic duct abnormalities with higher levels of sensitivity than magnetic resonance cholangiopancreatography (MRCP), researchers report in the September issue of Gastroenterology. Pancreatic imaging is an essential element in evaluation of patients with abdominal pain or suspected pancreatitis. MRCP allows physicians to visualize fluid

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