Technology
  • A Minimally Invasive Endoscopic Procedure Instead of Bariatric Surgery?

A Minimally Invasive Endoscopic Procedure Instead of Bariatric Surgery?

Endoscopic sleeve gastroplasty (ESG) delays gastric emptying, induces early satiation, and significantly reduces body weight, researchers report in the January issue of Clinical Gastroenterology and Hepatology. ESG could therefore be an alternative to bariatric surgery for some patients with obesity. Although bariatric surgery is the most effective therapy for obesity,

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  • Can a Smartphone App Monitor IBD Activity?

Can a Smartphone App Monitor IBD Activity?

Researchers have developed a mobile health index for remote monitoring of patients with inflammatory bowel diseases (IBD) that could be incorporated into a smartphone app. These findings are reported in the December issue of Clinical Gastroenterology and Hepatology. The shift from symptom-oriented to prevention-oriented care delivery has accelerated the development of

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  • Does Pancreatectomy With Islet Autotransplantation Benefit Patients With Recurrent Acute Pancreatitis?

Does Pancreatectomy With Islet Autotransplantation Benefit Patients With Recurrent Acute Pancreatitis?

In patients with recurrent acute pancreatitis, total pancreatectomy with islet autotransplantation (TPIAT) reduces pain and requirements for narcotic therapy, and increases quality of life, researchers report in the September issue of Clinical Gastroenterology and Hepatology. This treatment should be considered when medical and endoscopic therapies have failed. Recurrent acute pancreatitis, caused

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  • Can Microbial Dysbiosis Cause Colonic Inflammation?

Can Microbial Dysbiosis Cause Colonic Inflammation?

Dysbiosis contributes to the pathogenesis of inflammatory bowel diseases (IBD) by altering colonic expression of genes that regulate inflammation and the immune response, researchers report in the July issue of Cellular and Molecular Gastroenterology and Hepatology. An altered intestinal microbiota composition has been associated with IBD. However, it is not

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  • Can we Identify People With IBD Before Symptoms Develop?

Can we Identify People With IBD Before Symptoms Develop?

People have high plasma levels of interleukin-6 (IL6) and c-reactive protein years before they are diagnosed with inflammatory bowel diseases (IBD), researchers report in the June issue of Clinical Gastroenterology and Hepatology. These markers of systemic inflammation could be features of early-stage disease used to identify patients at risk. Crohn’s

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  • An Ex-vivo Model for Electrolyte Transport Along the Small Intestine

An Ex-vivo Model for Electrolyte Transport Along the Small Intestine

Undifferentiated or crypt-like, and differentiated or villus-like, human intestinal enteroids represent distinct points along the crypt–villus axis and can be used to characterize electrolyte transport processes along the small intestine, researchers report in the March issue of Gastroenterology. Studies of their duodenal enteroid model showed that electrogenic Na+/HCO3– cotransporter 1 in the

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  • What Changes Occur in the Intestine After Gastric Bypass vs Vertical Sleeve Gastrectomy ?

What Changes Occur in the Intestine After Gastric Bypass vs Vertical Sleeve Gastrectomy ?

The intestine adapts differently to Roux-en-Y gastric bypass (RYGB) than to vertical sleeve gastrectomy (VSG), researchers show in the February issue of Gastroenterology. RYGB increases intestinal glucose disposal whereas VSG delays glucose absorption, but each reduces glycemia. Bariatric surgeries such as RYGB and VSG are the most effective ways to resolve

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  • What Loci Determine Susceptibility to IBD in African Americans?

What Loci Determine Susceptibility to IBD in African Americans?

Although many of the same genetic variants determine susceptibility to inflammatory bowel diseases (IBD) in Caucasians and African Americans, researchers report the identification of variants and loci not previously associated with IBD in African American populations. Analyses of these could provide insight into the pathogenesis of IBD, researchers state in

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  • This is Your Brain on Anti-TNF Therapy

This is Your Brain on Anti-TNF Therapy

Anti-tumor necrosis factor (anti-TNF) agents rapidly reduce pain perception in brains of patients with Crohn’s disease, researchers show in the October issue of Gastroenterology. This observation could explain how clinical disease activity is often reduced long before signs of mucosal healing. Patients with Crohn’s disease treated with anti-TNF agents often report reductions in abdominal pain

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  • How Might PPIs Promote C difficile infection?

How Might PPIs Promote C difficile infection?

Proton pump inhibitors (PPIs) do not have a large effect on microbial diversity of the colon, but do affect specific taxa, including Streptococcaceae and Enterococcaceae, which mediate resistance to Clostridium difficile infection (CDI), researchers report in the October issue of Gastroenterology. This finding might provide a mechanism by which these drugs increase risk for CDI.

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