Technology
  • What Endoscopic Techniques are Available for Weight Loss?

What Endoscopic Techniques are Available for Weight Loss?

Endoscopic techniques have been approved by the FDA for management of obesity, with many new devices and technologies in development. The pros and cons of these approaches, and the questions to be answered, are covered in a review article by Andrew C. Storm et al in the November issue of Clinical

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  • Decreased Microvilli Length, and Associated Gene Expression Changes, in Patients With Crohn’s Disease

Decreased Microvilli Length, and Associated Gene Expression Changes, in Patients With Crohn’s Disease

In an analysis of intestinal tissues from patients with Crohn’s disease (CD), researchers identified specific changes in gene expression patterns that associate with histologic changes, such as differences in microvilli length. Decreased microvilli length, via decreased expression of the microvilli gene set, might contribute to epithelial malfunction and the chronic

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  • 500 Posts by the AGA Journals Blog

500 Posts by the AGA Journals Blog

This week the AGA Journals Blog has reached an important milestone — its 500th post! The blog was started in 2010 to help disseminate the important discoveries published in the AGA Journals to a broader audience. Eight years and over 132,000 views later, it has updated its readers on everything from biomarkers for colon

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  • Can Nonlytic T cells be Engineered to Fight HBV Infection?

Can Nonlytic T cells be Engineered to Fight HBV Infection?

Nonlytic T cells with receptors engineered to recognize HBV suppress virus replication in hepatocytes and limit infection of mice by activating APOBEC3, researchers report in the July issue of Gastroenterology. These cells are not hepatotoxic and might be developed for treatment of chronic HBV infection. T cells control chronic viral infections, and virus-specific

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  • Does Mucosal Healing Mean Transmural Healing in Children With Crohn’s Disease?

Does Mucosal Healing Mean Transmural Healing in Children With Crohn’s Disease?

 One-third of children with Crohn’s disease have healing in only the mucosa or the bowel wall (not both), researchers report in the July issue of Clinical Gastroenterology and Hepatology. Levels of fecal calprotectin below 300 μg/identify children with mucosal healing. In patients with CD, mucosal healing is associated with reduced risk of relapse,

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Gastroenterology Special Issue on Endoscopy

A special issue of Gastroenterology, Advances in Endoscopic Therapy, presents the latest advances in gastrointestinal endoscopy, including endoscopic images and videos. In their introductory article, Jacques J. Bergman and Patrick S. Yachimski explain that endoscopy is central to gastroenterology clinical practice and research, allowing examination of healthy and diseased tissue from the organ level, to the

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  • What are the Challenges to In Vitro Maturation of Hepatic Stem Cells?

What are the Challenges to In Vitro Maturation of Hepatic Stem Cells?

New approaches are needed to generate and maintain stable and mature adult liver cells ex vivo. In the April issue of Gastroenterology, Bart Spee and colleagues review factors that promote hepatocyte differentiation and maturation, and consider criteria for establishing whether cells derived from stem cells are fully mature hepatocytes. They discuss challenges to cell transplantation and

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  • VIDEO: Non-invasive Detection of Early- and Late-Stage PDAC

VIDEO: Non-invasive Detection of Early- and Late-Stage PDAC

Specific patterns of volatile organic compounds (VOCs) in urine samples can identify patients with pancreatic ductal adenocarcinoma (PDAC), researchers report in the February issue of Gastroenterology. The noninvasive technology, based on ion mobility spectrometry, can be used to discriminate between healthy individuals vs individuals with early- or advanced-stage cancer. VOCs are metabolic products of microbes that can

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  • Model: Microfabricated Crypt Scaffolds for Studying Human Colon Stem Cells

Model: Microfabricated Crypt Scaffolds for Studying Human Colon Stem Cells

Researchers created an in vitro human colon crypt array that provides an accurate representation of human intestinal crypts, reported in the February issue of Cellular and Molecular Gastroenterology and Hepatology. This system re-creates an intestinal epithelium with a high density of polarized crypts that respond in a physiologic manner to growth factors, metabolites, or

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  • Review: Diagnosis, Pathogenesis, and Treatment of Hepatorenal Syndrome in Patients With Cirrhosis

Review: Diagnosis, Pathogenesis, and Treatment of Hepatorenal Syndrome in Patients With Cirrhosis

Hepatorenal syndrome (HRS), a frequently fatal complication of decompensated cirrhosis, is difficult to evaluate due to challenges in assessment of glomerular filtration rate and level of renal dysfunction. In the February issue of Clinical Gastroenterology and Hepatology Ayse L. Mindikoglu and Stephen C. Pappas review strategies for diagnosis and assessment of renal function in patients with

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