Technology
  • Can an Antibody Against IL13 Be Used to Treat Eosinophilic Esophagitis?

Can an Antibody Against IL13 Be Used to Treat Eosinophilic Esophagitis?

A monoclonal antibody against IL13 reduced histologic and endoscopic features of eosinophilic esophagitis (EoE) in a placebo-controlled phase 2 trial, researchers report in the February issue of Gastroenterology. The antibody, called RPC4046, was well tolerated. EoE is a chronic, immune-mediated disease of the esophagus characterized by eosinophil-mediated mucosal inflammation and

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Is Endoscopic Submucosal Dissection the Best Treatment for Esophageal Cancer?

Lower proportions of patients with T1am2/m3 or T1b early-stage esophageal squamous cell carcinomas (EESCCs) treated with endoscopic submucosal dissection (ESD) have perioperative adverse events or disease-specific death after a median follow-up time of 21 months, researchers report in the January issue of Clinical Gastroenterology and Hepatology. The authors found no difference

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  • Simple Process for Generating Unlimited Intestinal Stem Cells From Endoscopic Biopsies

Simple Process for Generating Unlimited Intestinal Stem Cells From Endoscopic Biopsies

An efficient method for cloning gastrointestinal stem cells from biopsies collected during endoscopy is reported in the January isssue of Gastroenterology. A system is needed to isolate, clone, and examine the mucosal stem cells away from confounding effects of immune, stromal, and microbe cells. Markers of stem cells such as

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Identification of Human Monoclonal Antibodies That Neutralize Pandemic GII.4 Noroviruses

Human monoclonal antibodies able to neutralize live human norovirus GII.4 Sydney 2012—the predominant strain responsible for recent outbreaks—are reported in the December issue of Gastroenterology. Researchers analyzed these antibodies and identified the neutralizing epitopes, providing insight into the human immune response to this deadly virus. Human noroviruses are the major

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  • What Endoscopic Techniques are Available for Weight Loss?

What Endoscopic Techniques are Available for Weight Loss?

Endoscopic techniques have been approved by the FDA for management of obesity, with many new devices and technologies in development. The pros and cons of these approaches, and the questions to be answered, are covered in a review article by Andrew C. Storm et al in the November issue of Clinical

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  • Decreased Microvilli Length, and Associated Gene Expression Changes, in Patients With Crohn’s Disease

Decreased Microvilli Length, and Associated Gene Expression Changes, in Patients With Crohn’s Disease

In an analysis of intestinal tissues from patients with Crohn’s disease (CD), researchers identified specific changes in gene expression patterns that associate with histologic changes, such as differences in microvilli length. Decreased microvilli length, via decreased expression of the microvilli gene set, might contribute to epithelial malfunction and the chronic

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  • 500 Posts by the AGA Journals Blog

500 Posts by the AGA Journals Blog

This week the AGA Journals Blog has reached an important milestone — its 500th post! The blog was started in 2010 to help disseminate the important discoveries published in the AGA Journals to a broader audience. Eight years and over 132,000 views later, it has updated its readers on everything from biomarkers for colon

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  • Can Nonlytic T cells be Engineered to Fight HBV Infection?

Can Nonlytic T cells be Engineered to Fight HBV Infection?

Nonlytic T cells with receptors engineered to recognize HBV suppress virus replication in hepatocytes and limit infection of mice by activating APOBEC3, researchers report in the July issue of Gastroenterology. These cells are not hepatotoxic and might be developed for treatment of chronic HBV infection. T cells control chronic viral infections, and virus-specific

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  • Does Mucosal Healing Mean Transmural Healing in Children With Crohn’s Disease?

Does Mucosal Healing Mean Transmural Healing in Children With Crohn’s Disease?

 One-third of children with Crohn’s disease have healing in only the mucosa or the bowel wall (not both), researchers report in the July issue of Clinical Gastroenterology and Hepatology. Levels of fecal calprotectin below 300 μg/identify children with mucosal healing. In patients with CD, mucosal healing is associated with reduced risk of relapse,

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Gastroenterology Special Issue on Endoscopy

A special issue of Gastroenterology, Advances in Endoscopic Therapy, presents the latest advances in gastrointestinal endoscopy, including endoscopic images and videos. In their introductory article, Jacques J. Bergman and Patrick S. Yachimski explain that endoscopy is central to gastroenterology clinical practice and research, allowing examination of healthy and diseased tissue from the organ level, to the

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