Technology

Colon Complications from Anti-Inflammatory Drugs?

Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) are known to cause stomach problems, but a large prospective study by Lisa Strate et al. in the May issue of Gastroenterology shows that they can also damage the colon, causing diverticulitis and diverticular bleeding. Strate et al. tracked the use of aspirin,

Read more

What is the Best Strategy for Children with Celiac Disease?

Most children with potential celiac disease, based on serologic markers, remain healthy after 3 years—only about a third develop villous atrophy, report Antonella Tosco et al. in the April issue of Clinical Gastroenterology and Hepatology. However, antibody tests can identify children at greatest risk for the changes in the intestinal

Read more

Cleaning for Colonoscopy

GoLytely better prepares the colon for screening colonoscopy than MiraLAX, report Michael Hjelkrem et al. in the April issue of Clinical Gastroenterology and Hepatology. Efficient cleansing of the colon is one of the most important factors for successful colonscopy examination, but also a major reason that patients avoid screening—because of

Read more

As Incidence of HCV Infection Increases, a New Mouse Model to Study

The incidence of hepatitis C virus (HCV) infection and its complications—hepatocellular carcinoma (HCC) and cirrhosis—are increasing, according to Fasiha Kanwal et al. Fortunately, a new mouse model has been created to study disease progression and treatment, as described by Michael Washburn et al. These findings were reported in separate articles

Read more

Advance Against Hepatitis B

Long-term treatment with entecavir, an inhibitor of hepatitis B virus (HBV) replication, reduces cirrhosis and fibrosis in patients with chronic hepatitis B infection, report Eugene Schiff et al. in the March issue of Clinical Gastroenterology and Hepatology.  Patients with chronic hepatitis B can develop liver fibrosis or cirrhosis and have

Read more

Tracking Pancreatic Cancer Cells

Tumors spread to other parts of the body when cancer cells can escape into the bloodstream, although it is not exactly clear how they enter the circulation or decide where to form new tumors. Andrew Rhim and colleagues at the University of Pennsylvania have developed a technology to label tumor

Read more

Anti-Inflammatory Drugs Prevent Colorectal Cancer (for Some)

Aspirin and other anti-inflammatory drugs prevent colorectal cancer (CRC) in some people but not others, according to the March issue of Gastroenterology. Andrew Chan et al. found that these drugs reduce the risk of CRC only in women with high levels of soluble tumor necrosis factor receptor 2 (sTNFR-2), a

Read more

What Causes Weight Gain After Gastric Bypass?

A surgical complication, rather than eating habits, can cause patients to regain lost weight after gastric bypass surgery, reports Barham K. Abu Dayyeh et al. in the March issue of Clinical Gastroenterology and Hepatology. The authors correlated increased diameter of the gastrojejunal stoma with long-term weight gain after this common

Read more

Same Liver, New Location

Functional liver tissue can be grown in lymph nodes of mice and rescue them from lethal hepatic disease, reports Toshitaka Hoppo et al. in the February issue of Gastroenterology—lymph nodes therefore might someday be used as sites for hepatocyte transplantation in patients with end-stage liver disease. Many patients with chronic hepatic

Read more

What is the Best Strategy for Treating Pediatric Autoimmune Hepatitis?

Immunosuppressant therapy causes permanent recovery from liver failure in most children with autoimmune hepatitis (AIH), reports Miriam Cuarterolo et al. in the February issue of Clinical Gastroenterology and Hepatology. AIH is a progressive, inflammatory liver disease that predominantly affects girls before puberty. Without treatment, it progresses to cirrhosis and liver

Read more