Technology
  • This is Your Brain on Anti-TNF Therapy

This is Your Brain on Anti-TNF Therapy

Anti-tumor necrosis factor (anti-TNF) agents rapidly reduce pain perception in brains of patients with Crohn’s disease, researchers show in the October issue of Gastroenterology. This observation could explain how clinical disease activity is often reduced long before signs of mucosal healing. Patients with Crohn’s disease treated with anti-TNF agents often report reductions in abdominal pain

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  • How Might PPIs Promote C difficile infection?

How Might PPIs Promote C difficile infection?

Proton pump inhibitors (PPIs) do not have a large effect on microbial diversity of the colon, but do affect specific taxa, including Streptococcaceae and Enterococcaceae, which mediate resistance to Clostridium difficile infection (CDI), researchers report in the October issue of Gastroenterology. This finding might provide a mechanism by which these drugs increase risk for CDI.

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  • Special Issue: Genetics, Genetic Testing, and Biomarkers of Digestive Diseases

Special Issue: Genetics, Genetic Testing, and Biomarkers of Digestive Diseases

A special issue of Gastroenterology features 14 articles discussing the genetic factors that contribute to a range of gastrointestinal (GI),  hepatobiliary, and pancreatic diseases, and how this information can be used in diagnosis and treatment of patients. An introduction to the special issue explains the value of associating diseases with specific genetic variants, which can help

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  • VIDEO: Endoscopic Management of Gastrointestinal Leaks and Fistulae

VIDEO: Endoscopic Management of Gastrointestinal Leaks and Fistulae

Gastrointestinal leaks and fistulae can be serious acute complications or chronic conditions caused by inflammation, malignancy, or surgery. In a Perspective article in the October issue of Clinical Gastroenterology and Hepatology, Field F. Willingham and Jonathan M. Buscaglia discuss advanced endoscopic methods for less invasive treatment of these luminal defects. They explain that the main goal of

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  • ORCID: A System to Tie Authors With Their Publications
  • ORCID: A System to Tie Authors With Their Publications

ORCID: A System to Tie Authors With Their Publications

Wondering what to do if other researchers have the same name as you, or if you have published articles under different name formats? How can people tell which publications are yours? There is a solution: ORCID. ORCID (Open Researcher and Contributor ID) provides researchers with a unique digital identifier (an ORCID

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  • A Temperature-sensitive Gel For Topical Administration of Colitis Drugs

A Temperature-sensitive Gel For Topical Administration of Colitis Drugs

Researchers describe a system for topical delivery of drugs to patients with ulcerative colitis (UC). A polymer that holds and then releases UC drugs such as budesonide and mesalamine is liquid at room temperature, but turns into a viscous gel upon reaching body temperature, they report in the July issue of Gastroenterology. Systemic therapies for inflammatory

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  • A Quantitative Ultrasound Technology to Identify Patients with NAFLD and Quantify Steatohepatitis

A Quantitative Ultrasound Technology to Identify Patients with NAFLD and Quantify Steatohepatitis

A new quantitative ultrasound (QUS)  can accurately identify patients with non-alcoholic fatty liver disease (NAFLD) and quantify hepatic steatosis, researchers report in the July issue of Clinical Gastroenterology and Hepatology. With further validation, QUS could be an inexpensive, widely used technique to screen the general or at-risk population for NAFLD. The estimated prevalence of NAFLD

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  • Is FMT Ready for IBD?

Is FMT Ready for IBD?

Despite promising findings from 2 studies of fecal microbiota transplantation (FMT) in patients with ulcerative colitis, the technology should remain in clinical trials and is not ready for routine practice in patients with inflammatory bowel diseases (IBD), write Ari M. Grinspan and Colleen R. Kelly in an editorial. The success of FMT

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  • A Point of Care Test to Identify Patients With Celiac Disease Before Endoscopy

A Point of Care Test to Identify Patients With Celiac Disease Before Endoscopy

A rapid, point-of-care test for deamidated gliadin peptide antibody (DGP) identifies patients with celiac disease with similar levels of sensitivity and specificity as standard serologic analysis of antibodies to tissue transglutaminase (anti-tTG). Use of this test before endoscopy could identify the best candidates for duodenal biopsy analysis, leading to cost

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VIDEO: Endoscopic Suturing for Ulcer Exclusion

Researchers report the use of endoscopic surgical suturing for ulcer exclusion in the July issue of Gastroenterology, and provide a video of their procedure. It is important to prevent rebleeding of peptic ulcers. A prototype endoscopic suturing device has been developed to provide hemostasis in patients with massively bleeding gastric ulcers. Philip Wai Yan Chiu et

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