Gastrointestinal Bleeding Caused by Gastric Tuberculosis

Researchers describe a case of gastric tuberculosis that led to GI bleeding in the June issue of Clinical Gastroenterology and Hepatology. Vishal Sharma et al report that a 30-year-old man who was a resident of North India presented to emergency services with 2 episodes of painless hematemesis. He did not have a history of

Read more
  • Bioinformatic Search Identifies Tapeworm Drug for Treatment of Hepatocellular Carcinoma

Bioinformatic Search Identifies Tapeworm Drug for Treatment of Hepatocellular Carcinoma

In a bioinformatic search for agents that alter the hepatocellular carcinoma (HCC)-specific gene expression pattern, researchers identified the anthelmintic drug niclosamide as a potential anti-tumor agent, described in the June issue of Gastroenterology. Niclosamide and its ethanolamine salt (NEN), with greater bioavailability, slowed growth of genetically induced liver tumors and

Read more
  • FUSE Outperforms Forward-viewing Colonoscopy in Detecting Dysplasia in Patients With IBD

FUSE Outperforms Forward-viewing Colonoscopy in Detecting Dysplasia in Patients With IBD

The panoramic views obtained with full-spectrum endoscopy (FUSE) increase the number of dysplastic lesions detected in the colon, compared with conventional forward-viewing colonoscopy, researchers report in the May issue of Gastroenterology. Inflammatory bowel diseases (IBDs) increase the risk of colorectal cancer. Surveillance colonoscopy with chromoendoscopy is recommended, but conventional forward-viewing colonoscopy

Read more
  • What Factors Associate With Symptom Recurrence After Anti-reflux Surgery for GERD?

What Factors Associate With Symptom Recurrence After Anti-reflux Surgery for GERD?

The most reliable factors associated with symptom recurrence after anti-reflux surgery for patients with gastroesophageal reflux disease (GERD) are a primary complaint of extraesophageal reflux symptoms and lack preoperative response to acid-suppression therapy, researchers report in the May issue of Clinical Gastroenterology and Hepatology. Approximately 10% of the US population has

Read more
  • Gastroduodenal Metastases from Melanoma

Gastroduodenal Metastases from Melanoma

Researchers describe a case of gastroduodenal metastases from cutaneous melanoma, in the May issue of Gastroenterology. Inês Pita et al present the case of a 76-year-old man who arrived at the emergency department with exertional dyspnea and melena for the past 3 weeks, and an episode of presyncope. He denied orthopnea, paroxysmal nocturnal dyspnea,

Read more
  • Which Patients Are at Greatest Risk From Mushroom Poisoning?

Which Patients Are at Greatest Risk From Mushroom Poisoning?

Almost 20% of patients with liver damage from mushroom (Amanita) poisoning and peak levels of total bilirubin greater than 2 mg/dL require liver transplantation or die, researchers report in the May issue of Clinical Gastroenterology and Hepatology. The authors show that peak level of aspartate aminotransferase (AST) below 4000 IU/L identifies

Read more
  • What are the Effects of Prednisolone in Patients With Severe Alcoholic Liver Disease?

What are the Effects of Prednisolone in Patients With Severe Alcoholic Liver Disease?

Infections are frequent in patients with severe alcoholic liver disease, but are only independently associated with mortality when patients receive prednisolone, researchers report in the April issue of Gastroenterology. This could offset prednisolone’s therapeutic benefit. This study’s senior author, Mark Thursz, discusses the findings in a video abstract. As with

Read more
  • Does Good Oral Health Increase Risk for IBD?

Does Good Oral Health Increase Risk for IBD?

A population-based cohort study of more than 20,000 people in Sweden associated poor oral health with reduced risk for inflammatory bowel diseases (IBD). The article, in the April issue of Clinical Gastroenterology and Hepatology, reports that the protective effect increases with the severity of poor dental hygiene. Environmental factors, such as

Read more
  • What Causes Wheat Sensitivity in People Without Celiac Disease?

What Causes Wheat Sensitivity in People Without Celiac Disease?

Gluten-containing cereals have high concentrations of amylase-trypsin inhibitors (ATIs), which activate innate immunity via the toll-like receptor 4 (TLR4), researchers report in the April issue of Gastroenterology. These ATIs are resistant to proteases and heat, and increase intestinal inflammation by activating intestinal and mesenteric lymph node myeloid cells. Wheat is

Read more
  • Hemosuccus Pancreaticus Caused by a Pancreatic Tumor

Hemosuccus Pancreaticus Caused by a Pancreatic Tumor

Researchers describe a rare cause of hemosuccus pancreaticus in a patient with pancreatic cancer. The gastrointestinal bleeding was caused by erosion of pancreatic adenocarcinoma into the colon, they show in the April issue of Clinical Gastroenterology and Hepatology. Hemosuccus pancreaticus is defined as hemorrhage from the ampulla of Vater via the pancreatic

Read more
  • Efficacy of Endoscopic Sleeve Gastroplasty In Reducing Body Weight and Metabolic Complications

Efficacy of Endoscopic Sleeve Gastroplasty In Reducing Body Weight and Metabolic Complications

Endoscopic sleeve gastroplasty (ESG) sustains loss of total body weight for up to 24 months, and also reduces markers of hypertension, diabetes, and hypertriglyceridemia, researchers report from a prospective study published in the April issue of Clinical Gastroenterology and Hepatology. ESG is an incisionless, minimally invasive bariatric procedure that reduces the

Read more
  • What are the Different Types of Liver Cancer, and How do They Develop?

What are the Different Types of Liver Cancer, and How do They Develop?

A review article in the March issue of Gastroenterology discusses different hypotheses about the cells responsible for liver tumorigenesis. The article also reviews the different classes of liver tumors, based on the molecular features, and how these affect patient prognosis. Daniela Sia et al describe the distinct molecular and clinical features of hepatocellular

Read more
  • What is the Incidence of Achalasia?

What is the Incidence of Achalasia?

The incidence of achalasia is at least twice as high as previously believed, 2 studies (one from Chicago, the other from Australia) show in the March issue of Clinical Gastroenterology and Hepatology. Achalasia is characterized by dysphagia, regurgitation of undigested food, and chest pain. Patients lose weight due to the

Read more
  • What is the Active Ingredient in FMT for CDI?

What is the Active Ingredient in FMT for CDI?

Sterile fecal filtrates—containing bacterial debris, proteins, antimicrobial compounds, metabolic products, and microbial DNA, rather than intact microorganisms—appear to be effective for treatment of recurrent Clostridium difficile infection (CDI), researchers report in the March issue of Gastroenterology. Fecal microbiota transplantation (FMT) is an effective therapy of recurrent CDI—a single treatment resolves

Read more