What Causes Weight Gain After Gastric Bypass?

A surgical complication, rather than eating habits, can cause patients to regain lost weight after gastric bypass surgery, reports Barham K. Abu Dayyeh et al. in the March issue of Clinical Gastroenterology and Hepatology. The authors correlated increased diameter of the gastrojejunal stoma with long-term weight gain after this common

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Same Liver, New Location

Functional liver tissue can be grown in lymph nodes of mice and rescue them from lethal hepatic disease, reports Toshitaka Hoppo et al. in the February issue of Gastroenterology—lymph nodes therefore might someday be used as sites for hepatocyte transplantation in patients with end-stage liver disease. Many patients with chronic hepatic

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What is the Best Strategy for Treating Pediatric Autoimmune Hepatitis?

Immunosuppressant therapy causes permanent recovery from liver failure in most children with autoimmune hepatitis (AIH), reports Miriam Cuarterolo et al. in the February issue of Clinical Gastroenterology and Hepatology. AIH is a progressive, inflammatory liver disease that predominantly affects girls before puberty. Without treatment, it progresses to cirrhosis and liver

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IBD Guardian

Researchers have identified a molecule that protects colon cells from injury in a mouse model of inflammatory bowel disease (IBD). The study, published by Beth McConnell et al. in the February issue of Gastroenterology, reports that Klf5 controls genes that mediate recovery from colonic injury. Klf5 regulates transcription of genes

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Unsafe at Any Speed?

Driving privileges of people with hepatic encephalopathy (HE) should be restricted until they demonstrate that they are safe on the road, according to Stanley Martin Cohen et al. in the February issue of Clinical Gastroenterology and Hepatology. Because there are few laws about which patients with HE or other mental

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Which Patients with Cystic Fibrosis are at Greatest Risk for Pancreatitis?

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause well-known lung defects, but in the January issue of Gastroenterology, Chee Y. Ooi et al. describe specific CFTR genotypes that increase risk for pancreatitis. Most patients with cystic fibrosis that carry mutations that severely disrupt CFTR function have a pancreatic

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For Pancreatic Cysts—(Change in) Size Matters

The speed of cyst growth predicts whether branch duct intraductal papillary mucinous neoplasms (Br-IPMNs) will become malignant, according to a study by Mee Joo Kang et al. in the January issue of Clinical Gastroenterology and Hepatology. IPMN is a premalignant pancreatic lesion that progresses from adenoma to carcinoma; cysts are

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An HIV Protein and Telomerase Inhibitor Join Forces Against Cancer

Researchers have found a way to specifically kill liver cancer cells and stop tumor growth. In the January issue of Gastroenterology, Guangming Chen et al. report that fusion of a natural inhibitor of telomerase to an HIV protein stops proliferation of hepatocellular carcinoma (HCC) cells and growth of liver tumors

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Safe Bread for Celiacs

Baked goods made from fully hydrolyzed wheat flour, manufactured with sourdough lactobacilli and fungal proteases, are safe for patients with celiac disease, according to the January issue of Clinical Gastroenterology and Hepatology. Celiac disease is caused by an inflammatory response to wheat gluten. Luigi Greco et al. gave patients with celiac

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Colorectal Cancer in Cowden Syndrome

Patients with Cowden syndrome (CS) are at high risk for early-onset colorectal cancer, according to the December issue of Gastroenterology. CS is caused by mutations in the tumor suppressor gene phosphatase and tensin homolog (PTEN). Patients typically have mucocutaneous lesions, large-sized heads, and increased risk for breast, thyroid, and endometrial

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Fibrosis in Patients with HIV and Hepatitis C

HIV infection does not speed the progression of fibrosis in patients with Hepatitis C, according to findings from Richard Sterling et al. in the December issue of Clinical Gastroenterology and Hepatology. Sterling et al. compared liver biopsies taken from more than 300 patients with HIV/HCV co-infection and more than 200

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Relief from Irritable Bowel Syndrome

Patients with irritable bowel syndrome (IBS) had significant improvements in bowel habits and reductions in abdominal pain after taking a new drug called linaclotide, reports a study published in the December issue of Gastroenterology. Jeffrey M. Johnston et al. performed a placebo-controlled phase 2 trial of 4 different doses of

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Skin Problems from IBD Therapy?

Recurring and intense skin lesions cause one-third of patients that take anti-tumor necrosis factor (TNF) therapy for inflammatory bowel disease (IBD) to discontinue treatment, reports Jean–François Rahier et al. in the December issue of Clinical Gastroenterology and Hepatology. Anti-TNF agents are used to treat patients with a variety of immune

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Eating Away at Crohn’s Disease

Genetic features of many patients with Crohn’s disease affect the ability of their intestinal cells to undergo autophagy—a form of self-digestion that allows them to fight pathogenic bacteria, according to a study by Craig Homer et al. in the November issue of Gastroenterology. Crohn’s disease is believed to be caused

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