• Special Issue: Managing Patients With Liver Disease

Special Issue: Managing Patients With Liver Disease


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A special issue of Clinical Gastroenterology and Hepatology is dedicated to the clinical management of hepatic disorders, including nonalcoholic fatty liver disease (NAFLD), viral hepatitis, autoimmune hepatitis, and primary sclerosing cholangitis (PSC).

The issue comprises 14 review articles that aim to present clinicians with evidence-based guidance and expert opinions on management of patients with liver diseases.

W. Ray Kim et al present a comprehensive overview of the  burden of chronic, nonmalignant liver disease in the United States. Chronic liver diseases currently cause more than 2 million deaths each year, and incidence is increasing.

Yamini Natarajan and Fasiha Kanwal explain pay-for-performance programs in the United States, which started off as pay-for-performance initiatives, but evolved into a penalty-based program. The authors explain current measures in chronic liver disease, rates of submission, as well as the submission process and associated challenges.

Kavish R. Patidar and Jasmohan S. Bajaj discuss the diagnosis and management of covert and overt hepatic encephalopathy, and Stephen A. Harrison et al describe treatment and prevention strategies, and their outcomes, for patients with NAFLD.

Ira M. Jacobson et al provide the latest management algorithm for patients with chronic hepatitis B virus (HBV) infection, and John M. Vierling explains the features of autoimmune hepatitis.

Guadalupe Garcia-Tsao and Jaime Bosch review risk stratification of varices and variceal hemorrhage in patients with cirrhosis, David S. Goldberg and Michael B. Fallon discuss the heart and lung complications of liver disease, while Patrick S. Kamath et al describe scoring systems proposed for predicting outcomes of patients with acute-on-chronic liver failure. They say that treatment strategies depend on early recognition, supportive intensive care, and liver transplantation before organ failure.

Malignancies associated with PSC

Malignancies associated with PSC

Amit G. Singal and Hashem B. El-Serag explain how findings from liver epidemiology studies have been translated into treatment and prevention strategies.

Gregory J. Gores et al provide important information about risk factors for PSC and how it can lead to development of cholangiocarcinoma (see figure). These authors also report on advances in early detection and therapies.

Andrew J. Muir and Susanna Naggie ask whether it is possible to cure all patients with hepatitis C virus (HCV) infection, James H. Lewis provides the latest update on drug-induced liver injury, and Sumeet K. Asrani tells us how to incorporate noninvasive markers of liver fibrosis into clinical practice.

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