• Can We Use a Yeast Lipase in Enzyme Replacement Therapy for Pancreatic Exocrine Insufficiency?

Can We Use a Yeast Lipase in Enzyme Replacement Therapy for Pancreatic Exocrine Insufficiency?

An orally administered yeast lipase increases digestion of fat in a minipig model of pancreatic exocrine insufficiency (PEI), similar to that of pancreatin used in pancreatic enzyme replacement therapy, researchers report in the December issue of Gastroenterology. Patients with PEI have decreased pancreatic secretion of digestive enzymes such as lipase. This

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Fishing for Genes that Cause Biliary Atresia

A study of zebrafish has helped identify a susceptibility gene for biliary atresia, as reported in the May issue of Gastroenterology. Biliary atresia is a progressive fibro-inflammatory disorder of infants that involves the extrahepatic and intrahepatic biliary tree and causes obliteration of the ducts, leading to cholestasis, fibrosis, and cirrhosis.

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What Can We Learn from a Pig Model of FAP?

A pig model of intestinal adenoma development, described in the November issue of Gastroenterology, will improve our understanding of colorectal cancer development and could be used to evaluate new therapeutics. Familial adenomatous polyposis (FAP) is an inherited disease; patients develop dysplasias in the colon and rectum that develop to adenomatous

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IBD Guardian

Researchers have identified a molecule that protects colon cells from injury in a mouse model of inflammatory bowel disease (IBD). The study, published by Beth McConnell et al. in the February issue of Gastroenterology, reports that Klf5 controls genes that mediate recovery from colonic injury. Klf5 regulates transcription of genes

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