• Do NSAIDs Prevent PEP?

Do NSAIDs Prevent PEP?

Rectal indomethacin does not prevent pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP), researchers report from a randomized controlled study published in the April issue of Gastroenterology. These findings contradict more than a decade of evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the risk of post-ERCP pancreatitis (PEP). Acute pancreatitis is the

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  • Expert Panel Recommends Aspirin Therapy for Prevention of Colorectal Cancer

Expert Panel Recommends Aspirin Therapy for Prevention of Colorectal Cancer

For the first time, an expert panel has recommended aspirin therapy to prevent not only heart attacks but also colorectal cancer. The guideline for those at high risk of heart disease, published September 14 in a draft report from the US Preventive Services Task Force is the first time a major

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  • Do Selective Serotonin Reuptake Inhibitors Increase Risk for GI Bleeding?

Do Selective Serotonin Reuptake Inhibitors Increase Risk for GI Bleeding?

Use of selective serotonin reuptake inhibitors increases risk for upper gastrointestinal bleeding (UGIB) by 55%—and even more among patients also taking nonsteroidal anti-inflammatory or antiplatelet drugs, researchers report in the January issue of Clinical Gastroenterology and Hepatology. Risk might be reduced significantly by concomitant use of acid-suppressing drugs. Selective serotonin

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  • Video: Risk of Upper Gastrointestinal Bleeding From Different Drug Combinations

Video: Risk of Upper Gastrointestinal Bleeding From Different Drug Combinations

Combined use of nonselective nonsteroidal anti-inflammatory drugs (nNSAIDs), COX-2 selective inhibitors, or low-dose aspirin with selective serotonin reuptake inhibitors significantly increases the risk of upper gastrointestinal (GI) bleeding, researchers report in the October issue of Gastroenterology. In their case series analysis of data from 114,835 patients with upper GI bleeding (930,888 person-years of follow-up),

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An Aspirin a Day Won’t Kill You, But it Might Cause GI Bleeding

Taking an aspirin a day reduces the risk for death, but increases odds of gastrointestinal (GI) bleeding, according to a large meta-analysis published in the September issue of Clinical Gastroenterology and Hepatology. Daily low doses of acetylsalicylic acid (ASA, also known as aspirin, 75 to 325 mg per day) are

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