• FISH and Mutations Best Identify Biliary Stricture Malignancies

FISH and Mutations Best Identify Biliary Stricture Malignancies

Addition of fluorescence in situ hybridization (FISH) and mutation analyses to cytology analysis significantly increases the sensitivity of detection of malignancies in biliary strictures, researchers report in the June issue of Clinical Gastroenterology and Hepatology. These techniques can be performed using standard brush samples collected during endoscopic retrograde cholangiopancreatography, with mutations detected in

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  • A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease
  • A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease

A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease

A man with sickle cell disease with generalized pain and progressive jaundice originally thought to have cholangiocarcinoma was eventually found to have Rosai-Dorfman disease, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Arian Teymoorian et al describe the case of a 38-year-old black man with a history of

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  • A Mouse Model for Studying Pancreatic Tumor Resection and Adjuvant Therapy

A Mouse Model for Studying Pancreatic Tumor Resection and Adjuvant Therapy

Researchers have developed mice that develop focal, resectable pancreatic tumors closely resembling human pancreatic ductal adenocarcinomas (PDACs) that can be used to test adjuvant therapies, according to new research in the August issue of Gastroenterology. The authors show that administration of gemcitabine after resection of the tumors activates natural killer (NK) cell-mediated

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Pancreaticobiliary Maljunction and Neuroendocrine Carcinoma

Researchers describe an unusual case—a patient with a neuroendocrine carcinoma of the gallbladder accompanied by pancreaticobiliary maljunction—in the March issue of Clinical Gastroenterology and Hepatology. Tomonori Matsumoto et al examined a 58-year-old man with epigastric pain. Computed tomography (A) and fluoro-2-deoxy-d-glucose positron emission tomography (B) revealed angular diffuse thickening of the gallbladder

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  • Does a PNPLA3 Polymorphism Promote Fibrosis Progression in Patients with Hepatitis C?

Does a PNPLA3 Polymorphism Promote Fibrosis Progression in Patients with Hepatitis C?

A single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain containing 3 gene (PNPLA3) is associated with baseline level of fibrosis and its progression, but not development of hepatocellular carcinoma (HCC), in patients with hepatitis C virus (HCV) infection, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Most

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  • Gut Microbiome Determines Efficacy of Cancer Immunotherapy

Gut Microbiome Determines Efficacy of Cancer Immunotherapy

Specific groups of intestinal microbes can boost the anti-tumor effects of cancer immunotherapies in mice, researchers show. Cancer immunotherapies that block immune inhibitory pathways have been tested in patients with several tumor types, but responses have varied. A study published in Science, while not the first to link gut microbes

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  • Should Patients Undergo Endoscopic Sphincterotomy Before Receiving Self-expandable Metallic Stents?

Should Patients Undergo Endoscopic Sphincterotomy Before Receiving Self-expandable Metallic Stents?

Endoscopic sphincterotomy (ES) provides no benefit to patients receiving self-expandable metallic stents (SEMS) for a biliary stricture caused by pancreatic cancer, researchers report in the June issue of Clinical Gastroenterology and Hepatology. The randomized controlled trial showed that ES procedure did not affect number of adverse events, SEMS patency, or

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  • Special Issue: Food, the Immune System, and the GI Tract

Special Issue: Food, the Immune System, and the GI Tract

The digestion of food and absorption of nutrients is the principal role of the gastrointestinal (GI) tract—everyone wants to know what we should eat and how it affects our body. Interactions between food and the immune system affect our microbiome, development of food allergies, nutrition, risk for inflammatory disorders or cancer, and even

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  • Genetic Analysis of Tumors Could Improve With Proper Controls

Genetic Analysis of Tumors Could Improve With Proper Controls

Up to two thirds of mutations identified in tumors also exist in matched, non-tumor tissues, researchers have found. It is therefore important for oncologists to identify the mutations that actually promote the progression of a patient’s tumor before selecting therapy. The finding, published in Science Translational Medicine on 15 April, comes

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Genetic Analysis of Icelandic Population Provides Disease Insights

Scientists in Iceland have performed an unprecedentated genetic analysis of an entire nation, associating previously undiscovered mutations with disorders such as liver disease and gallstones. In 4 articles published last week in Nature Genetics, researchers at DeCODE, an Icelandic genetics firm owned by Amgen, described sequencing the genomes of 2636

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