• FISH and Mutations Best Identify Biliary Stricture Malignancies

FISH and Mutations Best Identify Biliary Stricture Malignancies

Addition of fluorescence in situ hybridization (FISH) and mutation analyses to cytology analysis significantly increases the sensitivity of detection of malignancies in biliary strictures, researchers report in the June issue of Clinical Gastroenterology and Hepatology. These techniques can be performed using standard brush samples collected during endoscopic retrograde cholangiopancreatography, with mutations detected in

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Pancreaticobiliary Maljunction and Neuroendocrine Carcinoma

Researchers describe an unusual case—a patient with a neuroendocrine carcinoma of the gallbladder accompanied by pancreaticobiliary maljunction—in the March issue of Clinical Gastroenterology and Hepatology. Tomonori Matsumoto et al examined a 58-year-old man with epigastric pain. Computed tomography (A) and fluoro-2-deoxy-d-glucose positron emission tomography (B) revealed angular diffuse thickening of the gallbladder

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A New Way to Detect Pancreatic Tumors?

Researchers have developed an ultrasound technique to image pancreatic tumors in mice, described in the October issue of Gastroenterology. This approach might useful in early detection of pancreatic ductal adenocarcinoma (PDAC). PDAC is the fourth leading cause of cancer death in the United States. It is usually diagnosed at an

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For Pancreatic Cysts—(Change in) Size Matters

The speed of cyst growth predicts whether branch duct intraductal papillary mucinous neoplasms (Br-IPMNs) will become malignant, according to a study by Mee Joo Kang et al. in the January issue of Clinical Gastroenterology and Hepatology. IPMN is a premalignant pancreatic lesion that progresses from adenoma to carcinoma; cysts are

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