• Do More People Have Celiac Disease in the North vs the South?

Do More People Have Celiac Disease in the North vs the South?

A higher proportion of persons living at latitudes of 35° North or greater have celiac disease or avoid gluten than persons living south of this latitude, researchers report in the June issue of Gastroenterology. This difference was independent of race or ethnicity, socioeconomic status, or body mass index. Several autoimmune

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  • How Could the Intestinal Microbiota Contribute to Celiac Disease?

How Could the Intestinal Microbiota Contribute to Celiac Disease?

Bacteria in the small intestine metabolize gluten differently, to increase or decrease its immunogenicity, researchers report in the October issue of Gastroenterology. This interaction between microbes and gluten could help determine the risk for autoimmune enteropathy in genetically susceptible individuals and underlie the reported association between dysbiosis and celiac disease.

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  • What Happens to Patients With Markers of Celiac Disease but no Symptoms?

What Happens to Patients With Markers of Celiac Disease but no Symptoms?

A 3-year study of adults with potential celiac disease found most to have symptoms, and that these adults improve after gluten withdrawal, as reported in the May issue of Clinical Gastroenterology and Hepatology. The study also shows that patients without symptoms should not go on gluten-free diets, because they are unlikely

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  • Should All Patients with IBS be Screened for Celiac Disease?

Should All Patients with IBS be Screened for Celiac Disease?

Screening patients with irritable bowel syndrome (IBS) or other functional gastrointestinal disorders for celiac disease isn’t much more effective than screening the general population, researchers report in the November issue of Clinical Gastroenterology and Hepatology. Celiac disease produces symptoms similar to those of IBS, such as lower abdominal pain, diarrhea,

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  • Is Nonceliac Gluten Sensitivity Real?

Is Nonceliac Gluten Sensitivity Real?

When patients with nonceliac gluten sensitivity (NCGS) unknowingly ingested small amounts of gluten for 1 week, they developed more severe abdominal pain and bloating that patients who ingested a matched placebo, researchers report in the September issue of Clinical Gastroenterology and Hepatology. The study provides evidence for a form of

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  • A Point of Care Test to Identify Patients With Celiac Disease Before Endoscopy

A Point of Care Test to Identify Patients With Celiac Disease Before Endoscopy

A rapid, point-of-care test for deamidated gliadin peptide antibody (DGP) identifies patients with celiac disease with similar levels of sensitivity and specificity as standard serologic analysis of antibodies to tissue transglutaminase (anti-tTG). Use of this test before endoscopy could identify the best candidates for duodenal biopsy analysis, leading to cost

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  • Special Issue: Food, the Immune System, and the GI Tract

Special Issue: Food, the Immune System, and the GI Tract

The digestion of food and absorption of nutrients is the principal role of the gastrointestinal (GI) tract—everyone wants to know what we should eat and how it affects our body. Interactions between food and the immune system affect our microbiome, development of food allergies, nutrition, risk for inflammatory disorders or cancer, and even

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  • Celiac Disease Risk Not Affected by Early Diet

Celiac Disease Risk Not Affected by Early Diet

Two studies have shown that neither breastfeeding nor timing the start of gluten-containing foods makes a difference in development of celiac disease in children at risk. The AP reported that the studies, published October 2 in the New England Journal of Medicine, show that there is no early window of

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  • Can Gluten-free Diets Benefit People with Asymptomatic Celiac Disease?

Can Gluten-free Diets Benefit People with Asymptomatic Celiac Disease?

A gluten-free diet (GFD) can benefit asymptomatic patients who test positive for celiac disease based on detection of with endomysial antibodies (EMA), researchers report in the September issue of Gastroenterology. This finding supports screening of patients at risk for celiac disease. Celiac disease is a lifelong disorder caused by ingested

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Does EGD Identify Causes of Abdominal Pain in Children?

Esophagogastroduodenoscopy (EGD) is a useful tool for the diagnosis of children with abdominal pain, researchers report in the June issue of Clinical Gastroenterology and Hepatology. The procedure identified disorders for which medical therapy was effective in 67% of children. Chronic abdominal pain is the most common indication for EGD in children.

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