• How Does Estrogen Receptor Signaling Promote Growth of Liver Tumors?

How Does Estrogen Receptor Signaling Promote Growth of Liver Tumors?

The G-protein–coupled estrogen receptor (GPER1) is a hepatic sensor of estrogen that regulates liver growth during development, regeneration, and tumorigenesis, researchers show in a study of zebrafish and human liver published in the May issue of Gastroenterology. Inhibitors of GPER1 might be developed for liver cancer prevention or treatment. Liver cancer

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Stem Cells Account for Different Fates of Adenomatous and Hyperplastic Polyps

Adenomatous polyps expand the pool of colon stem cells to become malignant, whereas hyperplastic polyps (HPPs) do not, and therefore remain benign, according to a study published in the September issue of Gastroenterology. Many colorectal cancers arise from adenomatous polyps, which contain mutations that inactivate the tumor suppressor APC. These

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