• An Ex-vivo Model for Electrolyte Transport Along the Small Intestine

An Ex-vivo Model for Electrolyte Transport Along the Small Intestine

Undifferentiated or crypt-like, and differentiated or villus-like, human intestinal enteroids represent distinct points along the crypt–villus axis and can be used to characterize electrolyte transport processes along the small intestine, researchers report in the March issue of Gastroenterology. Studies of their duodenal enteroid model showed that electrogenic Na+/HCO3– cotransporter 1 in the

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  • The Same Path to Pancreatitis From Alcohol Abuse or Cystic Fibrosis?

The Same Path to Pancreatitis From Alcohol Abuse or Cystic Fibrosis?

Excessive alcohol consumption disrupts expression and localization of the cystic fibrosis transmembrane conductance regulator (CFTR), researchers report in the February issue of Gastroenterology. People with loss-of-function mutations in the CFTR develop cystic fibrosis and are at risk for pancreatitis—the finding that alcohol intake also alters this protein could provide insight

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