• Intestinal Microbes as Carcinogens

Intestinal Microbes as Carcinogens

Fecal microbiota from patients with colorectal cancer (CRC) have carcinogenic properties, researchers report in the December issue of Gastroenterology. Feeding mice stool from patients with colorectal cancer (CRC) increased numbers of polyps, levels of intestinal dysplasia and proliferation, and markers of inflammation in colon, compared with stool from individuals without CRC, the scientists found.

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  • What do Enteric Glial Cells Do?

What do Enteric Glial Cells Do?

Enteric glial cells (EGCs) are important regulators of intestinal homeostasis—disruption of their activities can lead to digestive and extradigestive diseases. Michael Neunlist et al describe the neuroprotective effects of EGCs, how they regulate expression of neuromediators, and their roles as neuronal and glial progenitors in the enteric nervous system in a review article in the

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  • What are the Roles for Chemokines in Liver Disease?

What are the Roles for Chemokines in Liver Disease?

Sustained hepatic inflammation contributes to the progression of chronic liver diseases such as hepatitis C and non-alcoholic steatohepatitis. In the September issue of Gastroenterology, Fabio Marra and Frank Tacke review the roles of chemokines in liver inflammation and disease progression. In the liver, chemokines regulate the migration and activities of hepatocytes, Kupffer

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