A Special Issue on Viral Hepatitis

The May issue of Gastroenterology features a very special supplement—“Viral Hepatitis: A Changing Field”—comprising 17 review and commentary articles from international leaders in hepatitis treatment and research. The issue provides insight into the rapid progress made in the treatment and management of patients with viral hepatitis, as well as our

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Is Cardiac Surgery Safe for Patients With Cirrhosis?

Patients with compensated cirrhosis who undergo cardiac surgery with cardiopulmonary bypass do not have greater post-operative mortality or morbidity than other patients who receive this surgery, according to the May issue of Clinical Gastroenterology and Hepatology. Advanced liver disease is a significant risk factor for complications after cardiac surgery, but

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A Better Way to Make Pluripotent Cells From Liver Cells

Researchers have identified an efficient method for creating pluripotent stem cells from differentiated liver cells, according to the April issue of Gastroenterology. This technology could lead to new methods for therapeutic regeneration of diseased or damaged tissues. Embryonic stem cells are pluripotent, in that they can form the 3 germ

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Why are Some Immunized Children Still At Risk for HBV Infection?

Despite immunization, children born to mothers with replicating HBV (marked by hepatitis B e antigen, or HBeAg) are still at risk for infection, according to the April issue of Gastroenterology. Mother-to-infant transmission is the major cause of hepatitis B virus (HBV) infection among immunized children. There have been proposals to

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What Factors Predict Recovery From Chronic HBV Infection?

A low and rapidly decreasing level of Hepatitis B surface antigen (HBsAg) is a good sign for patients with chronic HBV infection, according to the March issue of Clinical Gastroenterology and Hepatology. Tracking progression of chronic HBV infection can be complicated—patients can have high viral loads with no symptoms, and

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How Do Lipids Affect Liver Disease?

Changes in lipid intake or metabolism can affect development of liver injury and fibrosis, according to two studies in mice published in the January issue of Gastroenterology. The liver is an important site of energy production and lipid metabolism. However, accumulation of excess fat in the liver promotes development of fibrosis, cirrhosis

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Can We Treat Chronic HCV Infection Without Interferon?

A potent combination of 2 drugs that directly target the hepatitis C virus (HCV) is effective in patients with chronic infection, and doesn’t require interferon therapy, according to an article in the December issue of Gastroenterology. Patients infected with HCV genotype-1 are usually treated with peginterferon and ribavirin, but approximately

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How Does Deferasirox Reduce Liver Fibrosis?

Liver fibrosis is reduced in patients with iron overload β-thalassemia and hepatitis C given the iron chelator deferasirox, according to Yves Deugnier et al. in the October issue of Gastroenterology. The liver is the main site of iron accumulation in patients with iron-overload disorders. Storage of excess iron in the

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What is the Best Strategy for Treating Pediatric Autoimmune Hepatitis?

Immunosuppressant therapy causes permanent recovery from liver failure in most children with autoimmune hepatitis (AIH), reports Miriam Cuarterolo et al. in the February issue of Clinical Gastroenterology and Hepatology. AIH is a progressive, inflammatory liver disease that predominantly affects girls before puberty. Without treatment, it progresses to cirrhosis and liver

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