• Do Patients Really Prefer Colon Capsule Endoscopy Over Colonoscopy?

Do Patients Really Prefer Colon Capsule Endoscopy Over Colonoscopy?

Slightly more than 50% of people with an inherited risk for colorectal cancer (CRC) agree to undergo screening for this cancer, and most prefer colonoscopy to colon capsule endoscopy—even though these are equally effective screening tools—researchers report in the December issue of Clinical Gastroenterology and Hepatology. Colonoscopy should therefore remain

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  • Special Issue: Genetics, Genetic Testing, and Biomarkers of Digestive Diseases

Special Issue: Genetics, Genetic Testing, and Biomarkers of Digestive Diseases

A special issue of Gastroenterology features 14 articles discussing the genetic factors that contribute to a range of gastrointestinal (GI),  hepatobiliary, and pancreatic diseases, and how this information can be used in diagnosis and treatment of patients. An introduction to the special issue explains the value of associating diseases with specific genetic variants, which can help

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  • Expert Panel Recommends Aspirin Therapy for Prevention of Colorectal Cancer

Expert Panel Recommends Aspirin Therapy for Prevention of Colorectal Cancer

For the first time, an expert panel has recommended aspirin therapy to prevent not only heart attacks but also colorectal cancer. The guideline for those at high risk of heart disease, published September 14 in a draft report from the US Preventive Services Task Force is the first time a major

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  • How do Differentiated Tumor Cells Support Cancer Stem Cells?

How do Differentiated Tumor Cells Support Cancer Stem Cells?

Differentiated colorectal cells produce stem cell factor (SCF) to activate KIT signaling in tumor-initiating cells, researchers report in the September issue of Gastroenterology. This pathway maintains the stem-like features of these tumor cells, predominantly under conditions of hypoxia. Colorectal tumors are organized hierarchically and their growth is mediated by an

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  • VEGF Signaling Prevents Senescence in Colorectal Tumors

VEGF Signaling Prevents Senescence in Colorectal Tumors

Vascular endothelial growth factor receptor-2 (VEGFR2) signaling prevents senescence of colorectal cancer cells by inactivating p21, researchers report in the July issue of Gastroenterology. Inactivation of this pathway correlates with survival of patients treated with anti-VEGF cancer drug bevacizumab. VEGF, a growth factor that has been well studied for its

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  • Can Capsule Colonoscopy Accurately Detect Polyps and Adenomas?

Can Capsule Colonoscopy Accurately Detect Polyps and Adenomas?

In an average-risk screening population, capsule colonoscopy identified individuals with polyps and adenomas with high levels of specificity, researchers report in the May issue of Gastroenterology. This procedure might be useful for patients who cannot undergo colonoscopy or who had incomplete colonoscopies. Capsule endoscopy, which involves an ingestible pill-sized endoscope that

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  • Veggie Diets, Especially With Fish, Cut Colorectal Cancer Risk

Veggie Diets, Especially With Fish, Cut Colorectal Cancer Risk

A vegetarian diet, especially one that includes fish, significantly reduces the risk of colorectal cancer, a large new study reports. These findings could lead to new strategies for cancer prevention. In the Adventist Health Study 2, researchers had 77,659 men and women from Seventh-day Adventist churches nationwide complete well-validated questionnaires

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  • What to do About Sessile Serrated Adenomas

What to do About Sessile Serrated Adenomas

Sessile serrated adenomas (SSAs), characterized by the saw-toothed appearance of the colonic crypts, form and progress to colorectal cancers (CRCs) via a different pathway than conventional adenomas and are thought to contribute to 20% to 35% of all cases of CRC. Although little is known about their pathogenesis, endoscopists must be aware of the unique features of SSAs to efficiently detect

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  • Review: LGR5 and Intestinal Stem Cells

Review: LGR5 and Intestinal Stem Cells

Since the discovery of LGR5 as a marker of intestinal stem cells, we have learned a great deal about the intestinal crypt stem cell niche. In the August issue of Gastroenterology Bon-Kyoung Koo and Hans Clevers review the discovery of crypt base columnar cells as LGR5+ adult stem cells and

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Video: New Tool Aids Determination of Colonoscopy Surveillance Intervals

With an increased emphasis on improving quality and decreasing costs, new tools are needed to improve adherence to evidence-based practices and guidelines in endoscopy. In a video abstract, Timothy D. Imler describes an automated system that uses natural language processing (NLP) and clinical decision support to facilitate determination of colonoscopy surveillance

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