• Intestinal Microbes as Carcinogens

Intestinal Microbes as Carcinogens

Fecal microbiota from patients with colorectal cancer (CRC) have carcinogenic properties, researchers report in the December issue of Gastroenterology. Feeding mice stool from patients with colorectal cancer (CRC) increased numbers of polyps, levels of intestinal dysplasia and proliferation, and markers of inflammation in colon, compared with stool from individuals without CRC, the scientists found.

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  • FUSE Outperforms Forward-viewing Colonoscopy in Detecting Dysplasia in Patients With IBD

FUSE Outperforms Forward-viewing Colonoscopy in Detecting Dysplasia in Patients With IBD

The panoramic views obtained with full-spectrum endoscopy (FUSE) increase the number of dysplastic lesions detected in the colon, compared with conventional forward-viewing colonoscopy, researchers report in the May issue of Gastroenterology. Inflammatory bowel diseases (IBDs) increase the risk of colorectal cancer. Surveillance colonoscopy with chromoendoscopy is recommended, but conventional forward-viewing colonoscopy

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  • What Gene Mutations Cause Familial Colorectal Cancers?

What Gene Mutations Cause Familial Colorectal Cancers?

Mutations in the DNA repair gene, FAN1, cause some inherited forms of colorectal cancer (CRC), researchers report in the September issue of Gastroenterology. Identification of another gene associated with this hereditary cancer will facilitate management of patients with family histories of cancer. Germline mutations in EPCAM, APC, MUTYH, POLE, POLD1, GREM1,

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Are All Patients With IBD at Increased Risk for Colorectal Cancer?

Although inflammatory bowel disease (IBD) increases risk for colorectal cancer (CRC), the risk is only substantial among patients with long-term, extensive colitis. Furthermore, CRC risk is reduced by thiopurine therapy, according to the July issue of Gastroenterology. Laurent Beaugerie et al. collected data from 19,486 patients with IBD (60% with

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What are the Risks for Relatives of Patients With Colorectal Cancer?

Close relatives of people with colorectal cancer (CRC) have a significant increase in prevalence of advanced neoplasms and should be screened for cancer, according to the March issue of Gastroenterology. Relatives of patients with CRC have been shown to be at increased risk for colorectal neoplasms, but little is known

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Colorectal Cancer in Cowden Syndrome

Patients with Cowden syndrome (CS) are at high risk for early-onset colorectal cancer, according to the December issue of Gastroenterology. CS is caused by mutations in the tumor suppressor gene phosphatase and tensin homolog (PTEN). Patients typically have mucocutaneous lesions, large-sized heads, and increased risk for breast, thyroid, and endometrial

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