• How Does Transforming Growth Factor beta Suppress Colorectal Tumor Development?

How Does Transforming Growth Factor beta Suppress Colorectal Tumor Development?

Researchers review the mechanisms by which loss of transforming growth factor beta (TGFB) proteins contribute to development and progression of colorectal cancer in the January 2017 issue of Gastroenterology. Development and progression of colorectal cancerĀ involve loss of tumor suppressor proteins, including transforming growth factor beta (TGFB) family members. In colon

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  • Biomarker of Early-stage Aggressive Colon Cancer

Biomarker of Early-stage Aggressive Colon Cancer

Lack of the biomarker CDX2 identifies a subgroup of patients with high-risk stage II colon cancer who appeared to benefit from adjuvant chemotherapy. These patients are usually treated with surgery alone. The findings come from a study published online January 21 in the New England Journal of Medicine. Piero Dalerba

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  • Can a Cocktail Prevent Colorectal Adenoma Recurrence?

Can a Cocktail Prevent Colorectal Adenoma Recurrence?

The combination of calcitriol, aspirin, and calcium carbonate did not prevent recurrence of colorectal adenomas over a 3-year period, found a prospective study published in the January issue of Gastroenterology. This negative result might have been affected by the numbers of smokers included in the study or low doses of

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  • Expert Panel Recommends Aspirin Therapy for Prevention of Colorectal Cancer

Expert Panel Recommends Aspirin Therapy for Prevention of Colorectal Cancer

For the first time, an expert panel has recommended aspirin therapy to prevent not only heart attacks but also colorectal cancer. The guideline for those at high risk of heart disease, published September 14 in a draft report from the USĀ Preventive Services Task Force is the first time a major

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  • How do Differentiated Tumor Cells Support Cancer Stem Cells?

How do Differentiated Tumor Cells Support Cancer Stem Cells?

Differentiated colorectal cells produce stem cell factor (SCF) to activate KIT signaling in tumor-initiating cells, researchers report in the September issue of Gastroenterology. This pathway maintains the stem-like features of these tumor cells, predominantly under conditions of hypoxia. Colorectal tumors are organized hierarchically and their growth is mediated by an

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  • Veggie Diets, Especially With Fish, Cut Colorectal Cancer Risk

Veggie Diets, Especially With Fish, Cut Colorectal Cancer Risk

A vegetarian diet, especially one that includes fish, significantly reduces the risk of colorectal cancer, a large new study reports. These findings could lead to new strategies for cancer prevention. In the Adventist Health Study 2, researchers had 77,659 men and women from Seventh-day Adventist churches nationwide complete well-validated questionnaires

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Are All Patients With IBD at Increased Risk for Colorectal Cancer?

Although inflammatory bowel disease (IBD) increases risk for colorectal cancer (CRC), the risk is only substantial among patients with long-term, extensive colitis. Furthermore, CRC risk is reduced by thiopurine therapy, according to the July issue of Gastroenterology. Laurent Beaugerie et al. collected data from 19,486 patients with IBD (60% with

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What are the Risks for Relatives of Patients With Colorectal Cancer?

Close relatives of people with colorectal cancer (CRC) have a significant increase in prevalence of advanced neoplasms and should be screened for cancer, according to the March issue of Gastroenterology. Relatives of patients with CRC have been shown to be at increased risk for colorectal neoplasms, but little is known

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What Can We Learn from a Pig Model of FAP?

A pig model of intestinal adenoma development, described in the November issue of Gastroenterology, will improve our understanding of colorectal cancer development and could be used to evaluate new therapeutics. Familial adenomatous polyposis (FAP) is an inherited disease; patients develop dysplasias in the colon and rectum that develop to adenomatous

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New Cell Culture Technology for Colon Cancer and Barrett’s Esophagus

A new method for long-term culture of human primary colonic epithelium provides an important tool for studying colon stem cells, adenocarcinoma, colon cancer, and even Barrett’s esophagus, according to the November issue of Gastroenterology. Self-renewal of the small intestinal and colonic epithelium is mediated by proliferation of stem cells and

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