What Can We Learn from a Pig Model of FAP?

A pig model of intestinal adenoma development, described in the November issue of Gastroenterology, will improve our understanding of colorectal cancer development and could be used to evaluate new therapeutics. Familial adenomatous polyposis (FAP) is an inherited disease; patients develop dysplasias in the colon and rectum that develop to adenomatous

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New Cell Culture Technology for Colon Cancer and Barrett’s Esophagus

A new method for long-term culture of human primary colonic epithelium provides an important tool for studying colon stem cells, adenocarcinoma, colon cancer, and even Barrett’s esophagus, according to the November issue of Gastroenterology. Self-renewal of the small intestinal and colonic epithelium is mediated by proliferation of stem cells and

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