• Does Mucosal Healing Mean Transmural Healing in Children With Crohn’s Disease?

Does Mucosal Healing Mean Transmural Healing in Children With Crohn’s Disease?

 One-third of children with Crohn’s disease have healing in only the mucosa or the bowel wall (not both), researchers report in the July issue of Clinical Gastroenterology and Hepatology. Levels of fecal calprotectin below 300 μg/identify children with mucosal healing. In patients with CD, mucosal healing is associated with reduced risk of relapse,

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  • What Happens When Patients With Crohn’s Disease in Remission Stop Taking Infliximab?

What Happens When Patients With Crohn’s Disease in Remission Stop Taking Infliximab?

When patients with Crohn’s disease in sustained remission stopped taking infliximab for a median 7 years, almost one fifth did not require retreatment or have a major complication, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Fewer than one fifth of patients required surgery or developed a complex perianal fistula. Increasing numbers of patients

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  • Does Immunomodulator Therapy for IBD During Pregnancy Affect Newborn Response to Vaccines?

Does Immunomodulator Therapy for IBD During Pregnancy Affect Newborn Response to Vaccines?

Rates of adequate serologic response to Haemophilus influenzae B (HiB) and tetanus vaccines are similar among infants born to women with inflammatory bowel diseases (IBD) treated with immunomodulator or biologic agents compared to women who did not receive these immunosuppressive drugs during pregnancy, researchers report in the January issue of Clinical Gastroenterology

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  • Which Patients With Flat Low-grade Dysplasia are at High Risk for Colorectal Cancer?

Which Patients With Flat Low-grade Dysplasia are at High Risk for Colorectal Cancer?

Detection of flat low-grade dysplasia (fLGD) and aneuploidy in colon tissues increases risk for high-grade dysplaisa (HGD) or colorectal cancer (CRC) more than 5-fold in patients with inflammatory bowel disease (IBD), researchers report in the December issue of Gastroenterology. Aneuploidy was also detected in almost all cases of flat HGD (fHGD) IBD is a risk

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  • Does Asthma Increase Risk for Inflammatory Bowel Diseases?

Does Asthma Increase Risk for Inflammatory Bowel Diseases?

A population-based case–control study published in the September issue of Clinical Gastroenterology and Hepatology associates asthma with later development of Crohn’s disease (CD) and with ulcerative colitis (UC). Although the etiology of asthma and inflammatory bowel diseases (IBD) are not well understood, they both involve complex interactions among genetic and environmental factors and the

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  • Is Endoscopic Balloon Dilation Better Than Surgery for Patients With Crohn’s Disease-related Strictures?

Is Endoscopic Balloon Dilation Better Than Surgery for Patients With Crohn’s Disease-related Strictures?

In patients with Crohn’s disease (CD), surgical treatment of ileocolonic anastomosis strictures reduces risk of further surgery compared with endoscopic balloon dilation (EBD), researchers report in the August issue of Clinical Gastroenterology and Hepatology. However, endoscopic balloon dilation (EBD) delays time until need for a second surgery; EBD should be therefore attempted first

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  • Does Good Oral Health Increase Risk for IBD?

Does Good Oral Health Increase Risk for IBD?

A population-based cohort study of more than 20,000 people in Sweden associated poor oral health with reduced risk for inflammatory bowel diseases (IBD). The article, in the April issue of Clinical Gastroenterology and Hepatology, reports that the protective effect increases with the severity of poor dental hygiene. Environmental factors, such as

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  • Can Vitamin D Affect Risk of Ulcerative Colitis Relapse?

Can Vitamin D Affect Risk of Ulcerative Colitis Relapse?

Serum levels of vitamin D of 35 ng/mL or less in patients with ulcerative colitis (UC) in clinical remission are associated with disease relapse, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Increasing patients’ levels of vitamin D might reduce their risk for UC relapse. Vitamin D

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  • Do Relatives of Patients With IBD Also Have Intestinal Dysbiosis?

Do Relatives of Patients With IBD Also Have Intestinal Dysbiosis?

The intestinal microbiota of many healthy, first-degree relatives of patients with inflammatory bowel diseases (IBD) is dysbiotic, signifying a pre-disease state, low-level inflammation, and susceptibility to IBD, researchers report in the November issue of Cellular and Molecular Gastroenterology and Hepatology. Changes in the intestinal microbiome are involved in the pathogenesis

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  • Can Microbial Dysbiosis Cause Colonic Inflammation?

Can Microbial Dysbiosis Cause Colonic Inflammation?

Dysbiosis contributes to the pathogenesis of inflammatory bowel diseases (IBD) by altering colonic expression of genes that regulate inflammation and the immune response, researchers report in the July issue of Cellular and Molecular Gastroenterology and Hepatology. An altered intestinal microbiota composition has been associated with IBD. However, it is not

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