Does IBD Increase Risk for Oral Cancer?

Patients with inflammatory bowel diseases (IBD) have an increased risk of oral cancers—especially tongue cancer—researchers report in the March issue of Clinical Gastroenterology and Hepatology. Women are at higher risk than men. Oral cancers develop in the mucosal surfaces of the lips, floor of mouth, tongue, buccal mucosa, lower and

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Should Patients with Crohn’s Disease Continue Receiving Immunomodulators When Starting Anti-TNF Therapy?

Continued use of immunomodulator therapy in patients with Crohn’s disease receiving anti-tumor necrosis factor (TNF) therapy is no more effective than anti-TNF monotherapy in inducing or maintaining response or remission, researchers show. The meta-analysis of randomized controlled trials is published in the December issue of Clinical Gastroenterology and Hepatology. There is debate

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  • What Loci Determine Susceptibility to IBD in African Americans?

What Loci Determine Susceptibility to IBD in African Americans?

Although many of the same genetic variants determine susceptibility to inflammatory bowel diseases (IBD) in Caucasians and African Americans, researchers report the identification of variants and loci not previously associated with IBD in African American populations. Analyses of these could provide insight into the pathogenesis of IBD, researchers state in

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  • This is Your Brain on Anti-TNF Therapy

This is Your Brain on Anti-TNF Therapy

Anti-tumor necrosis factor (anti-TNF) agents rapidly reduce pain perception in brains of patients with Crohn’s disease, researchers show in the October issue of Gastroenterology. This observation could explain how clinical disease activity is often reduced long before signs of mucosal healing. Patients with Crohn’s disease treated with anti-TNF agents often report reductions in abdominal pain

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  • Anemia—a Real Problem for Patients With IBD

Anemia—a Real Problem for Patients With IBD

Persistent or recurrent anemia is associated with severe and disabling inflammatory bowel disease (IBD), researchers report in the October issue of Clinical Gastroenterology and Hepatology. Persistent or recurrent anemia could be used as a marker of severe disease and to identify patients who require aggressive management. Anemia is a well-recognized but underestimated problem

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  • What are the Effects of Antiviral Therapy in Patients With IBD and CMV Infection?

What are the Effects of Antiviral Therapy in Patients With IBD and CMV Infection?

Cytomegalovirus (CMV) infection complicates inflammatory bowel disease (IBD), but anti-viral therapy reduces the need for bowel surgery, researchers report in the May issue of Clinical Gastroenterology and Hepatology. The benefits of anti-viral treatment are greatest for patients with high-grade disease, they show. CMV infection is more common in patients with

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  • Special Issue: Food, the Immune System, and the GI Tract

Special Issue: Food, the Immune System, and the GI Tract

The digestion of food and absorption of nutrients is the principal role of the gastrointestinal (GI) tract—everyone wants to know what we should eat and how it affects our body. Interactions between food and the immune system affect our microbiome, development of food allergies, nutrition, risk for inflammatory disorders or cancer, and even

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Video Abstract: Increased Risk of Cervical Cancer in Women with IBD

Women with ulcerative colitis or Crohn’s disease are at increased risk for cervical neoplasias, researchers report in the April issue of Clinical Gastroenterology and Hepatology. Christine Rungoe et al performed a population-based cohort study of 27,408 women with inflammatory bowel diseases (IBD). In her video abstract, she says “we observed that women with ulcerative

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  • Are People of Indian Origin at Higher Risk for IBD?

Are People of Indian Origin at Higher Risk for IBD?

People of Indian origin living in the United States have a greater than average risk for all types of inflammatory bowel diseases (IBD) than other American populations, researchers report in the April issue of Clinical Gastroenterology and Hepatology. East Asians and Hispanics have a lower risk, similar to that of the populations still

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  • Food Emulsifiers Increase Intestinal Permeability to Promote Inflammation

Food Emulsifiers Increase Intestinal Permeability to Promote Inflammation

Food additives commonly used to thicken and stabilize processed foods disrupt the intestinal microbiota to cause inflammation, researchers found in a study of mice. Emulsifiers are added to foods to hold together mixtures of fat and water, which would otherwise separate. Healthy mice fed a diet containing commonly used emulsifiers (1%

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