• Are People of Indian Origin at Higher Risk for IBD?

Are People of Indian Origin at Higher Risk for IBD?

People of Indian origin living in the United States have a greater than average risk for all types of inflammatory bowel diseases (IBD) than other American populations, researchers report in the April issue of Clinical Gastroenterology and Hepatology. East Asians and Hispanics have a lower risk, similar to that of the populations still

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  • Food Emulsifiers Increase Intestinal Permeability to Promote Inflammation

Food Emulsifiers Increase Intestinal Permeability to Promote Inflammation

Food additives commonly used to thicken and stabilize processed foods disrupt the intestinal microbiota to cause inflammation, researchers found in a study of mice. Emulsifiers are added to foods to hold together mixtures of fat and water, which would otherwise separate. Healthy mice fed a diet containing commonly used emulsifiers (1%

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  • Chronic use of Narcotics Among Children with IBD

Chronic use of Narcotics Among Children with IBD

Chronic use of narcotics is common among children with inflammatory bowel disease (IBD)—particularly among those with anxiety and depression, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Identifying and treating psychological disorders could reduce symptoms that lead to narcotic use and their complications in these patients. Narcotics are prescribed

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Podcast: Efficacy of Vedolizumab in Patients with Moderately to Severely Active Crohn’s disease

Listen to Bruce Sands discuss his article in the September issue of Gastroenterology discussing results from placebo-controlled, phase 3 double-blind trial of the efficacy of vedolizumab  in patients with moderately to severely active Crohn’s disease, including those for whom previous anti-TNF treatment had failed. Sands et al. report that vedolizumab, an antibody against the integrin α4β7, is no more effective

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Does EGD Identify Causes of Abdominal Pain in Children?

Esophagogastroduodenoscopy (EGD) is a useful tool for the diagnosis of children with abdominal pain, researchers report in the June issue of Clinical Gastroenterology and Hepatology. The procedure identified disorders for which medical therapy was effective in 67% of children. Chronic abdominal pain is the most common indication for EGD in children.

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Are IBD Drugs Safe During Pregnancy?

Researchers find no evidence that inflammatory bowel disease (IBD) during pregnancy, or medical treatment for IBD during pregnancy, increases risk for congenital abnormalities in children. The findings, based on a large database analysis, are published in the January issue of Gastroenterology. IBD frequently affects women of reproductive age, and is often

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  • Cannabis for Crohn’s Disease?

Cannabis for Crohn’s Disease?

Eight weeks of therapy with Δ9-tetrahydrocannabinol (THC)-rich cannabis reduced symptoms in patients with active Crohn’s disease, according to a controlled trial published in the October issue of Clinical Gastroenterology and Hepatology. However, these effects were only temporary. The marijuana plant Cannabis sativa has been used for centuries to treat a

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Are All Patients With IBD at Increased Risk for Colorectal Cancer?

Although inflammatory bowel disease (IBD) increases risk for colorectal cancer (CRC), the risk is only substantial among patients with long-term, extensive colitis. Furthermore, CRC risk is reduced by thiopurine therapy, according to the July issue of Gastroenterology. Laurent Beaugerie et al. collected data from 19,486 patients with IBD (60% with

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How Does PSC Lead to IBD?

Many patients with primary sclerosing cholangitis (PSC) also have inflammatory bowel disease (IBD), which becomes more severe after liver transplantation, researchers report in the May issue of Clinical Gastroenterology and Hepatology. These patients might require special immunosuppressive regimens. PSC is a chronic, cholestatic liver disease that eventually leads to cirrhosis

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What are the Effects of IBD Therapy During Pregnancy?

In pregnant women treated for inflammatory bowel diseases (IBD),  infliximab and adalimumab, but not certolizumab, cross the placenta and are detected in infants up to 6 months after birth, according to the March issue of Clinical Gastroenterology and Hepatology (CGH). However, they do not appear to cause birth defects, and women

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