• How do Differentiated Tumor Cells Support Cancer Stem Cells?

How do Differentiated Tumor Cells Support Cancer Stem Cells?

Differentiated colorectal cells produce stem cell factor (SCF) to activate KIT signaling in tumor-initiating cells, researchers report in the September issue of Gastroenterology. This pathway maintains the stem-like features of these tumor cells, predominantly under conditions of hypoxia. Colorectal tumors are organized hierarchically and their growth is mediated by an

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Could Bone Marrow Cells Contribute to Stomach Cancer?

H pylori recruit bone marrow-derived cells to the gastric mucosa that contribute to tumor development, according to the February issue of Gastroenterology. H pylori infection promotes gastric carcinogenesis through many mechanisms, such as causing inflammation and producing virulence factors that alter gastric cell activity. Over time, these lead to metaplasia, dysplasia,

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