• Efficacy of Endoscopic Sleeve Gastroplasty In Reducing Body Weight and Metabolic Complications

Efficacy of Endoscopic Sleeve Gastroplasty In Reducing Body Weight and Metabolic Complications

Endoscopic sleeve gastroplasty (ESG) sustains loss of total body weight for up to 24 months, and also reduces markers of hypertension, diabetes, and hypertriglyceridemia, researchers report from a prospective study published in the April issue of Clinical Gastroenterology and Hepatology. ESG is an incisionless, minimally invasive bariatric procedure that reduces the

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  • Does Pancreatectomy With Islet Autotransplantation Benefit Patients With Recurrent Acute Pancreatitis?

Does Pancreatectomy With Islet Autotransplantation Benefit Patients With Recurrent Acute Pancreatitis?

In patients with recurrent acute pancreatitis, total pancreatectomy with islet autotransplantation (TPIAT) reduces pain and requirements for narcotic therapy, and increases quality of life, researchers report in the September issue of Clinical Gastroenterology and Hepatology. This treatment should be considered when medical and endoscopic therapies have failed. Recurrent acute pancreatitis, caused

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  • What Changes Occur in the Intestine After Gastric Bypass vs Vertical Sleeve Gastrectomy ?

What Changes Occur in the Intestine After Gastric Bypass vs Vertical Sleeve Gastrectomy ?

The intestine adapts differently to Roux-en-Y gastric bypass (RYGB) than to vertical sleeve gastrectomy (VSG), researchers show in the February issue of Gastroenterology. RYGB increases intestinal glucose disposal whereas VSG delays glucose absorption, but each reduces glycemia. Bariatric surgeries such as RYGB and VSG are the most effective ways to resolve

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  • Does Controlling Glycemia Increase Gastric Emptying in Patients with Diabetes?

Does Controlling Glycemia Increase Gastric Emptying in Patients with Diabetes?

Two-thirds of patients with poorly controlled type 2 diabetes have mostly asymptomatic yet abnormal gastric emptying, researchers report in the March issue of Clinical Gastroenterology and Hepatology. However, sustained improvements in glycemic control do not affect gastric emptying, the researchers found in a prospective study. Diabetes is associated with delayed

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  • Food Emulsifiers Increase Intestinal Permeability to Promote Inflammation

Food Emulsifiers Increase Intestinal Permeability to Promote Inflammation

Food additives commonly used to thicken and stabilize processed foods disrupt the intestinal microbiota to cause inflammation, researchers found in a study of mice. Emulsifiers are added to foods to hold together mixtures of fat and water, which would otherwise separate. Healthy mice fed a diet containing commonly used emulsifiers (1%

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  • Who is on the Liver Transplant Waitlist?

Who is on the Liver Transplant Waitlist?

The number of adults with nonalcoholic steatohepatitis (NASH) waiting for liver transplants has almost tripled in the last 10 years, researchers report in the March issue of Gastroenterology. NASH is now the second leading liver disease of adults awaiting liver transplantation in the United States, the researchers found. The prevalence of nonalcoholic fatty

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FDA Approves New Obesity Drug

The US Food and Drug Administration (FDA) approved the third new prescription drug for obesity since 2012. The drug, Contrave, to be used along with a low-calorie diet and exercise regimen, was approved for treatment of obese adults (body mass index [BMI] of 30 or greater) or overweight adults (BMI

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Preventing Hypoglycemia After Gastric Bypass

Many patients who undergo gastric bypass surgery experience hypoglycemia after meals. Researchers report in the March issue of Gastroenterology that they can correct this condition with an agent that blocks the receptor for the glucagon-like peptide 1 (GLP1). Roux-en-Y gastric bypass surgery, widely used to treat obesity, alters glucose metabolism in

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Which Patients With Barrett’s Esophagus Will Develop Esophageal Cancer?

Researchers have found markers to identify patients with Barrett’s esophagus (BE) at greatest risk of developing esophageal adenocarcinoma. These are described in the August issue of Clinical Gastroenterology and Hepatology. In patients with BE, part of the normal stratified squamous epithelium of the lower esophagus is replaced with metaplastic columnar

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Could Intestinal Microbes Reduce Insulin Resistance?

The intestinal microbiota can be manipulated to increase insulin sensitivity in people with metabolic syndrome, according to a study published in the October issue of Gastroenterology. The trillions of microorganisms that reside in the human intestine are important regulators of metabolism. Changes in their composition and metabolic function have been

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