• Why do Pancreatic Tumor Cells Love the Liver?

Why do Pancreatic Tumor Cells Love the Liver?

Pancreatic ductal adenocarcinoma (PDAC) and its precursors secrete high levels of tissue inhibitor of metalloproteinases 1 (TIMP1) into the circulation, which activates hepatic stellate cells (HSCs) in liver. These cells help create a niche that promotes metastasis of pancreatic tumors to liver, researchers report in the November issue of Gastroenterology.

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  • Do Patients Really Prefer Colon Capsule Endoscopy Over Colonoscopy?

Do Patients Really Prefer Colon Capsule Endoscopy Over Colonoscopy?

Slightly more than 50% of people with an inherited risk for colorectal cancer (CRC) agree to undergo screening for this cancer, and most prefer colonoscopy to colon capsule endoscopy—even though these are equally effective screening tools—researchers report in the December issue of Clinical Gastroenterology and Hepatology. Colonoscopy should therefore remain

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How Can We Tell if Patients are Still at Risk for HCC after HCV Therapy?

For patients with chronic Hepatitis C virus infection, high levels of α-fetoprotein after therapy can identify those at risk for hepatocellular carcinoma (HCC), researchers report in the July issue of Clinical Gastroenterology and Hepatology. In persons with chronic HCV infection, lack of sustained virologic response (SVR) 24 weeks after the end

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Video: New Tool Aids Determination of Colonoscopy Surveillance Intervals

With an increased emphasis on improving quality and decreasing costs, new tools are needed to improve adherence to evidence-based practices and guidelines in endoscopy. In a video abstract, Timothy D. Imler describes an automated system that uses natural language processing (NLP) and clinical decision support to facilitate determination of colonoscopy surveillance

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  • Cancer Cells in Circulation

Cancer Cells in Circulation

Pancreatic cancer cells can be detected in patients’ circulation before tumors are discovered, researchers report in the March issue of Gastroenterology. Cancer cells have long been believed to acquire metastatic potential after large primary tumors are established. However, many patients undergoing pancreatectomy for chronic pancreatitis are found to have disseminated pancreatic

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Why Does Colonoscopy Protect Against Left-Sided Cancers?

Polyps with advanced pathology are significantly smaller in the right than left colon, and are therefore more likely to be missed during colonoscopy examinations, according to the December issue of Clinical Gastroenterology and Hepatology. Mortality from colorectal cancer (CRC) is decreasing, in part because colonoscopy screening is increasing, leading to

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What are the Barriers to CRC Screening?

Waiving copayments for colonoscopy examinations to detect colorectal cancer (CRC) increases the number of patients that undergo screening, according to a study published in the July issue of Clinical Gastroenterology and Hepatology. Colonoscopy is a recommended, cost-effective method of CRC screening that appears to reduce mortality, yet only half of

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