• What is the Active Ingredient in FMT for CDI?

What is the Active Ingredient in FMT for CDI?

Sterile fecal filtrates—containing bacterial debris, proteins, antimicrobial compounds, metabolic products, and microbial DNA, rather than intact microorganisms—appear to be effective for treatment of recurrent Clostridium difficile infection (CDI), researchers report in the March issue of Gastroenterology. Fecal microbiota transplantation (FMT) is an effective therapy of recurrent CDI—a single treatment resolves

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  • Long-term Efficacy of Octreotide in Patients with Polycystic Kidney and Liver Disease

Long-term Efficacy of Octreotide in Patients with Polycystic Kidney and Liver Disease

Three years of long-acting release octreotide (octreotide LAR) significantly reduced liver volume in patients with polycystic kidney and liver disease, researchers found in a placebo-controlled study. These reductions, reported in the July issue of Clinical Gastroenterology and Hepatology, were maintained for 2 years after treatment ended. Polycystic liver disease (PLD)

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  • Do NSAIDs Prevent PEP?

Do NSAIDs Prevent PEP?

Rectal indomethacin does not prevent pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP), researchers report from a randomized controlled study published in the April issue of Gastroenterology. These findings contradict more than a decade of evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the risk of post-ERCP pancreatitis (PEP). Acute pancreatitis is the

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  • Is Combination Therapy Most Effective for HBV Infection?

Is Combination Therapy Most Effective for HBV Infection?

A significantly greater proportion of patients receiving a combination of tenofovir disoproxil fumarate (TDF) and pegylated interferon-α (peginterferon) for 48 weeks lost hepatitis B surface antigen (HBsAg), a marker of hepatitis B virus (HBV) DNA transcriptional activity, compared to patients given the standard care (peginterferon or TDF alone), researchers report

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Is Stretta an Effective Treatment for GERD?

An expensive radiofrequency ablation technique known as Stretta does not benefit patients with gastroesophageal reflux disease (GERD), researchers report in the June issue of Clinical Gastroenterology and Hepatology. In a meta-analysis of randomized controlled studies, Seth Lipka et al found no evidence that Stretta normalized esophageal pH values, augmented lower esophageal

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  • An Effective and Long-lasting Hepatitis E Vaccine

An Effective and Long-lasting Hepatitis E Vaccine

A long-term study of a hepatitis E virus (HEV) vaccine showed that it is 86.8% effective and that immunity can last for up to 4.5 years. In a blinded, placebo-controlled, phase 3 trial, Jun Zhang et al randomly assigned 112,604 healthy adults in Dongtai (in the Jiangsu province of China)

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New Ways to Treat HCV Infection After Liver Transplant

New direct-acting agents against hepatitis C virus (HCV) can cure the infection when it recurs in patients with liver transplants. Researchers reported findings from 3 separate studies at the 65th Annual Meeting of the American Association for the Study of Liver Diseases last week in Boston. HCV is the leading

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  • Can Mesalamine Prevent Diverticulitis Recurrence?

Can Mesalamine Prevent Diverticulitis Recurrence?

Mesalamine is no better than placebo in preventing recurrent diverticulitis, and is not recommended for its treatment, researchers conclude from 2 international phase 3 studies. The findings are published in the October issue of Gastroenterology. Diverticular disease is characterized by formation of small pouches (diverticula) that push outward through weak spots in the colon wall.  Diverticulitis

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What Patient Factors Affect Bowel Preparation for Colonoscopy?

Bowel preparation is suboptimal for about one third of adults older than 55 undergoing outpatient colonoscopy, says the March issue of Clinical Gastroenterology and Hepatology. Diabetes and low level of patient engagement in their own health care contribute to less-than-optimal preparation, the researchers show. Colonoscopy is an important screening tool for

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Should Everybody Be Tested for Celiac Disease?

Not only does celiac disease cause abdominal pain, diarrhea, and bloating—untreated disease leads to progressive bone loss and derangements, increasing the risk for early osteoporosis and fractures of the hip and vertebrae. The June issue of Clinical Gastroenterology and Hepatology reports that current screening strategies to identify people with celiac

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