• What Changes Occur in the Esophageal Epithelial Barrier During Disease Development?

What Changes Occur in the Esophageal Epithelial Barrier During Disease Development?

A review article in the May issue of Clinical Gastroenterology and Hepatology discusses esophageal epithelial barrier structure and function, new and old techniques for studying this barrier, and changes that occur during development of esophageal diseases. To identify mechanisms of diseases associated with barrier dysfunction, such as gastroesophageal reflux disease (GERD), eosinophilic esophagitis,

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  • Can Disruption of the Intestinal Epithelial Barrier Contribute to Steatohepatitis?

Can Disruption of the Intestinal Epithelial Barrier Contribute to Steatohepatitis?

Mice with defects in intestinal epithelial permeability develop more severe steatohepatitis when placed on a diet high in saturated fat, fructose, and cholesterol (HFCD) than control mice, and colon tissues from patients with non-alcoholic fatty liver disease (NAFLD) have similar defects in intestinal epithelial permeability, researchers report in the October

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  • How is Notch Activated in Intestinal Stem Cells?

How is Notch Activated in Intestinal Stem Cells?

The enzyme ADAM10 serves as a cellular scissors that clips and activates Notch in the intestine, required for subsequent cell lineage specification and intestinal stem cell survival, researchers report in the October issue of Gastroenterology. These Notch-activated stem cells appear to have a competitive advantage for replenishing the stem cell

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