• What are the Most Accurate Non-invasive Techniques for Measuring Liver Fibrosis and Steatosis?

What are the Most Accurate Non-invasive Techniques for Measuring Liver Fibrosis and Steatosis?

Magnetic resonance elastography (MRE) is more accurate than transient elastography (TE) in identifying liver fibrosis of stage 1 or more, researchers report in the February issue of Gastroenterology, using biopsy analysis as the standard. They also show that MRI-based proton density fat fraction (MRI-PDFF) analysis is more accurate than TE-based

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  • Can Disruption of the Intestinal Epithelial Barrier Contribute to Steatohepatitis?

Can Disruption of the Intestinal Epithelial Barrier Contribute to Steatohepatitis?

Mice with defects in intestinal epithelial permeability develop more severe steatohepatitis when placed on a diet high in saturated fat, fructose, and cholesterol (HFCD) than control mice, and colon tissues from patients with non-alcoholic fatty liver disease (NAFLD) have similar defects in intestinal epithelial permeability, researchers report in the October

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  • Can Blood Levels of Ammonia Predict Risk and Frequency of Hepatic Encephalopathy in Patients With Cirrhosis?

Can Blood Levels of Ammonia Predict Risk and Frequency of Hepatic Encephalopathy in Patients With Cirrhosis?

Fasting levels of ammonia (NH3) in blood identify patients at risk for complications of overt hepatic encephalopathy (HE), researchers report in the June issue of Clinical Gastroenterology and Hepatology. Patients with HE might benefit from NH3-lowering therapy. Humans have no repository for excess dietary nitrogen, so we convert excess dietary

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  • What is the Best Treatment for Severe Alcoholic Hepatitis?

What is the Best Treatment for Severe Alcoholic Hepatitis?

Corticosteroids, alone or in combination with pentoxifylline or N-acetylcysteine (NAC), reduce short-term mortality in patients with severe alcoholic hepatitis, a meta-analysis shows in the October issue of Gastroenterology. However, there is no treatment to reduce medium-term mortality, the authors find. Severe alcoholic hepatitis is characterized by progressive inflammatory injury to hepatocytes and

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  • Video: Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis

Video: Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis

Obeticholic acid significantly reduces biochemical features of primary biliary cirrhosis (PBC) in patients with an inadequate response to ursodeoxycholic acid (UDCA) therapy, Gideon M. Hirschfield et al report in the April issue of Gastroenterology. Hirschfield discusses the details of the study and its findings in a video abstract: PBC is a progressive, autoimmune

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  • Does FibroScan Accurately Assess Liver Fibrosis?

Does FibroScan Accurately Assess Liver Fibrosis?

Vibration-controlled transient elastography (VCTE) with FibroScan can provide an accurate assessment of liver fibrosis in patients with chronic viral hepatitis, but operator-related and patient-related factors affect measurements, report 2 articles published in the April issue of Clinical Gastroenterology and Hepatology. The lowest levels of variation occur in patients with no

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  • Probiotics for Cirrhosis?

Probiotics for Cirrhosis?

A probiotic solution significantly reduced the risk of hospitalization for hepatic encephalopathy and markers of liver disease severity in patients with cirrhosis, researchers report in the December issue of Gastroenterology. Hepatic encephalopathy develops in 50%–70% of patients with cirrhosis; fewer than 50% of these patients survive for 1 year. Rifaximin and

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  • Can Exercise Help Patients with Cirrhosis?

Can Exercise Help Patients with Cirrhosis?

Eight weeks of aerobic exercise training increased peak oxygen uptake by muscle and muscle mass, and reduced fatigue, in patients with cirrhosis, researchers report in the November issue of Clinical Gastroenterology and Hepatology. Cirrhosis is characterized not only by hepatic fibrosis and progressive liver dysfunction, but also reduced exercise tolerance, based on decreased peak exercise

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  • What are the Roles for Chemokines in Liver Disease?

What are the Roles for Chemokines in Liver Disease?

Sustained hepatic inflammation contributes to the progression of chronic liver diseases such as hepatitis C and non-alcoholic steatohepatitis. In the September issue of Gastroenterology, Fabio Marra and Frank Tacke review the roles of chemokines in liver inflammation and disease progression. In the liver, chemokines regulate the migration and activities of hepatocytes, Kupffer

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Podcast: How Does Fatty Liver Affect Risk for Cardiovascular Disease?

Modification of risk factors for cardiovascular disease—particularly dyslipidemia—is required to reduce morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). In a Perspective article published in the July issue of Clinical Gastroenterology and Hepatology, Kathleen E. Corey and Naga Chalasani discuss the increased risk of cardiovascular disease among patients with NAFLD, and strategies

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