• How Does Smoking Lead to Pancreatic Cancer?

How Does Smoking Lead to Pancreatic Cancer?

Nicotine promotes pancreatic carcinogenesis by disrupting signaling and transcriptional pathways to cause dedifferentiation of acinar cells, researchers report in the November issue of Gastroenterology. One fourth of all deaths from pancreatic ductal adenocarcinoma (PDAC) are associated with tobacco use, and heavy smoking increases risk for PDAC 6-fold. Although smokers develop PDAC

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