Genetic Analysis of Icelandic Population Provides Disease Insights

Scientists in Iceland have performed an unprecedentated genetic analysis of an entire nation, associating previously undiscovered mutations with disorders such as liver disease and gallstones. In 4 articles published last week in Nature Genetics, researchers at DeCODE, an Icelandic genetics firm owned by Amgen, described sequencing the genomes of 2636

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What is the Best Way to Assess Bile Duct Strictures?

Researchers describe new methods to collect and process bile duct biopsies for evaluation of strictures, in the September issue of Clinical Gastroenterology and Hepatology. These approaches should provide a greater quantity of material for analysis and increase the accuracy of diagnosis. A biliary stricture is an abnormal narrowing of the

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Treatment for Gallstones?

Cholesterol gallstone disease might be treated with activators of the pregnane X receptor (PXR) such as St. John’s Wort, according to a study in the June issue of Gastroenterology. Cholesterol gallstone disease is caused by a biochemical imbalance of lipids and bile salts in the gallbladder bile. Jinhan He et

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