Who Will Develop Colorectal Cancer at a Young Age?

A screen for mutations in mismatch repair (MMR) genes could be used to identify young people at risk for colorectal cancer, report Paul Limburg et al. in the June issue of Clinical Gastroenterology and Hepatology. It is a challenge to identify people who are less than 50 years old that

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Which Patients with Cystic Fibrosis are at Greatest Risk for Pancreatitis?

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause well-known lung defects, but in the January issue of Gastroenterology, Chee Y. Ooi et al. describe specific CFTR genotypes that increase risk for pancreatitis. Most patients with cystic fibrosis that carry mutations that severely disrupt CFTR function have a pancreatic

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Eating Away at Crohn’s Disease

Genetic features of many patients with Crohn’s disease affect the ability of their intestinal cells to undergo autophagy—a form of self-digestion that allows them to fight pathogenic bacteria, according to a study by Craig Homer et al. in the November issue of Gastroenterology. Crohn’s disease is believed to be caused

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