• What Factors Associate With Symptom Recurrence After Anti-reflux Surgery for GERD?

What Factors Associate With Symptom Recurrence After Anti-reflux Surgery for GERD?

The most reliable factors associated with symptom recurrence after anti-reflux surgery for patients with gastroesophageal reflux disease (GERD) are a primary complaint of extraesophageal reflux symptoms and lack preoperative response to acid-suppression therapy, researchers report in the May issue of Clinical Gastroenterology and Hepatology. Approximately 10% of the US population has

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  • Can Histologic Features Identify Patients with GERD?

Can Histologic Features Identify Patients with GERD?

Total epithelial thickness is a robust histologic marker that can be used in detection of gastroesophageal reflux disease (GERD), researchers report in the November issue of Clinical Gastroenterology and Hepatology. GERD can be a challenge to diagnose because its symptoms overlap with those of other disorders. Endoscopy and esophageal pH

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  • LARS vs PPIs for Treatment of GERD?

LARS vs PPIs for Treatment of GERD?

Patients receiving laparoscopic anti-reflux surgery (LARS) for chronic gastroesophageal reflux disease (GERD) had significantly greater long-term reductions in 24-hour esophageal acid exposure than patients given esomeprazole, researchers report in the May issue of Clinical Gastroenterology and Hepatology. However, both treatments controlled symptoms in most patients, and esophageal and gastric pH were not

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Obesity Appears to Contribute to Increasing Use of Prescription Drugs

Prescription drug use in the United States increased by 8% over a 10 year period, and users of 5 or more prescription drugs almost doubled. Increases in prescriptions for specific agents appears to reflect the growing need for treatment of complications associated with the increase in overweight and obesity. The

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Is Stretta an Effective Treatment for GERD?

An expensive radiofrequency ablation technique known as Stretta does not benefit patients with gastroesophageal reflux disease (GERD), researchers report in the June issue of Clinical Gastroenterology and Hepatology. In a meta-analysis of randomized controlled studies, Seth Lipka et al found no evidence that Stretta normalized esophageal pH values, augmented lower esophageal

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Putting a Cap on Acid Reflux

Researchers show that a polysaccharide ‘raft’ can float on top of acid in the stomach to block its backflow into the esophagus. It reduces reflux symptoms in patients with gastroesophageal reflux disease (GERD), according to a clinical trial the December issue of Clinical Gastroenterology and Hepatology. GERD is a common condition

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Are There Stem Cells in the Esophagus and Stomach?

Researchers have identified potential stem cells in human esophagus and stomach, as well as those in metaplastic esophagus that could lead to esophageal cancer, according to the April issue of Gastroenterology. Stem cells have been reported to exist in the basal layer of the human esophagus—their progeny are believed to

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Does a Response to Proton Pump Inhibitor Therapy Indicate GERD?

Just because a patient’s upper gastrointestinal symptoms are alleviated by proton pump inhibitors (PPIs) doesn’t necessarily mean that they have gastroesophageal reflux disease (GERD), according to the December issue of Clinical Gastroenterology and Hepatology. The efficacy of PPI therapy often is tested to determine whether patients’ symptoms are acid-related and

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Many Patients Without GERD Continue to Take PPIs

More than 42% of patients with negative results from pH monitoring studies continue proton pump inhibitor (PPI) therapy, despite evidence that they do not have gastroesophageal reflux disease (GERD), according to the June issue of Clinical Gastroenterology and Hepatology. PPI therapy is effective for about 75% of patients with GERD

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Reflux and Laryngitis—a Complicated Relationship

Results from a large clinical trial show that proton pump inhibitors relieve some, but not all the symptoms of chronic laryngitis. One type of laryngitis, laryngopharyngeal reflux (LPR), is characterized by hoarseness, chronic cough, frequent throat clearing, and the feeling of something in the throat. Because it is believed to

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