• What Causes Wheat Sensitivity in People Without Celiac Disease?

What Causes Wheat Sensitivity in People Without Celiac Disease?

Gluten-containing cereals have high concentrations of amylase-trypsin inhibitors (ATIs), which activate innate immunity via the toll-like receptor 4 (TLR4), researchers report in the April issue of Gastroenterology. These ATIs are resistant to proteases and heat, and increase intestinal inflammation by activating intestinal and mesenteric lymph node myeloid cells. Wheat is

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  • What Happens to Patients With Markers of Celiac Disease but no Symptoms?

What Happens to Patients With Markers of Celiac Disease but no Symptoms?

A 3-year study of adults with potential celiac disease found most to have symptoms, and that these adults improve after gluten withdrawal, as reported in the May issue of Clinical Gastroenterology and Hepatology. The study also shows that patients without symptoms should not go on gluten-free diets, because they are unlikely

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  • A Point of Care Test to Identify Patients With Celiac Disease Before Endoscopy

A Point of Care Test to Identify Patients With Celiac Disease Before Endoscopy

A rapid, point-of-care test for deamidated gliadin peptide antibody (DGP) identifies patients with celiac disease with similar levels of sensitivity and specificity as standard serologic analysis of antibodies to tissue transglutaminase (anti-tTG). Use of this test before endoscopy could identify the best candidates for duodenal biopsy analysis, leading to cost

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  • Can Gluten-free Diets Benefit People with Asymptomatic Celiac Disease?

Can Gluten-free Diets Benefit People with Asymptomatic Celiac Disease?

A gluten-free diet (GFD) can benefit asymptomatic patients who test positive for celiac disease based on detection of with endomysial antibodies (EMA), researchers report in the September issue of Gastroenterology. This finding supports screening of patients at risk for celiac disease. Celiac disease is a lifelong disorder caused by ingested

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What Happens After Patients are Diagnosed With Celiac Disease?

Most patients with celiac disease are not adequately followed, according to the August issue of Clinical Gastroenterology and Hepatology (CGH). Improving follow-up strategies for patients with celiac disease could improve their outcomes. Adherence to a gluten-free diet is the only effective treatment for celiac disease. This is a difficult diet

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What is the Best Strategy for Children with Celiac Disease?

Most children with potential celiac disease, based on serologic markers, remain healthy after 3 years—only about a third develop villous atrophy, report Antonella Tosco et al. in the April issue of Clinical Gastroenterology and Hepatology. However, antibody tests can identify children at greatest risk for the changes in the intestinal

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