• Do More People Have Celiac Disease in the North vs the South?

Do More People Have Celiac Disease in the North vs the South?

A higher proportion of persons living at latitudes of 35° North or greater have celiac disease or avoid gluten than persons living south of this latitude, researchers report in the June issue of Gastroenterology. This difference was independent of race or ethnicity, socioeconomic status, or body mass index. Several autoimmune

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  • What Causes Wheat Sensitivity in People Without Celiac Disease?

What Causes Wheat Sensitivity in People Without Celiac Disease?

Gluten-containing cereals have high concentrations of amylase-trypsin inhibitors (ATIs), which activate innate immunity via the toll-like receptor 4 (TLR4), researchers report in the April issue of Gastroenterology. These ATIs are resistant to proteases and heat, and increase intestinal inflammation by activating intestinal and mesenteric lymph node myeloid cells. Wheat is

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  • How Could the Intestinal Microbiota Contribute to Celiac Disease?

How Could the Intestinal Microbiota Contribute to Celiac Disease?

Bacteria in the small intestine metabolize gluten differently, to increase or decrease its immunogenicity, researchers report in the October issue of Gastroenterology. This interaction between microbes and gluten could help determine the risk for autoimmune enteropathy in genetically susceptible individuals and underlie the reported association between dysbiosis and celiac disease.

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  • Should All Patients with IBS be Screened for Celiac Disease?

Should All Patients with IBS be Screened for Celiac Disease?

Screening patients with irritable bowel syndrome (IBS) or other functional gastrointestinal disorders for celiac disease isn’t much more effective than screening the general population, researchers report in the November issue of Clinical Gastroenterology and Hepatology. Celiac disease produces symptoms similar to those of IBS, such as lower abdominal pain, diarrhea,

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  • Is Nonceliac Gluten Sensitivity Real?

Is Nonceliac Gluten Sensitivity Real?

When patients with nonceliac gluten sensitivity (NCGS) unknowingly ingested small amounts of gluten for 1 week, they developed more severe abdominal pain and bloating that patients who ingested a matched placebo, researchers report in the September issue of Clinical Gastroenterology and Hepatology. The study provides evidence for a form of

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Does Celiac Disease Increase the Risk of GI Cancer?

People with celiac disease do not have an increased risk of developing gastrointestinal (GI) cancers, according to a large population-based study from Peter Elfström et al. in the January issue of Clinical Gastroenterology and Hepatology. Celiac disease has been associated with GI cancers in small studies, but there have been

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