• What Comes First — the Psychological Disorder or the Gastrointestinal Disorder?

What Comes First — the Psychological Disorder or the Gastrointestinal Disorder?

More patients receive a diagnosis of a mood or anxiety disorder before diagnosis of a functional gastrointestinal disorder (FGID), researchers report in the July issue of Clinical Gastroenterology and Hepatology. The findings indicate opportunities for prevention and support the role of adverse socioeconomic factors in development of FGIDs in patients

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  • Gut Microbiome Determines Efficacy of Cancer Immunotherapy

Gut Microbiome Determines Efficacy of Cancer Immunotherapy

Specific groups of intestinal microbes can boost the anti-tumor effects of cancer immunotherapies in mice, researchers show. Cancer immunotherapies that block immune inhibitory pathways have been tested in patients with several tumor types, but responses have varied. A study published in Science, while not the first to link gut microbes

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  • How Might PPIs Promote C difficile infection?

How Might PPIs Promote C difficile infection?

Proton pump inhibitors (PPIs) do not have a large effect on microbial diversity of the colon, but do affect specific taxa, including Streptococcaceae and Enterococcaceae, which mediate resistance to Clostridium difficile infection (CDI), researchers report in the October issue of Gastroenterology. This finding might provide a mechanism by which these drugs increase risk for CDI.

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  • Food Emulsifiers Increase Intestinal Permeability to Promote Inflammation

Food Emulsifiers Increase Intestinal Permeability to Promote Inflammation

Food additives commonly used to thicken and stabilize processed foods disrupt the intestinal microbiota to cause inflammation, researchers found in a study of mice. Emulsifiers are added to foods to hold together mixtures of fat and water, which would otherwise separate. Healthy mice fed a diet containing commonly used emulsifiers (1%

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How Good Gut Microbes Resist Inflammation

Gut commensal bacteria survive inflammation by making a simple switch to their protective coats, researchers show. When harmful microbes like salmonella infect the gut, the innate immune system produces antimicrobial peptides to kill them. But these pathogenic microbes are often similar to the commensal microbes that live in the gut—it was

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  • Author Q and A Series: Alcohol, the Microbiota, and Liver Disease

Author Q and A Series: Alcohol, the Microbiota, and Liver Disease

Chronic alcohol consumption disrupts the intestinal microbiota to reduce production of saturated long-chain fatty acids and subsequently the proportion and functions of hepatoprotective lactobacilli, Peng Chen et al report in the January issue of Gastroenterology. Dietary approaches to restore levels of saturated fatty acids in the intestine might therefore reduce ethanol-induced liver injury in patients with

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  • Special Issue: The Gut Microbiome

Special Issue: The Gut Microbiome

Gastroenterology is proud to present a special issue devoted to ‘The Gut Microbiome in Health and Disease’. The human body contains over 10 times more microbial cells than human cells. This microbiome (the commensal, symbiotic, and pathogenic microorganisms that share our body space) maintains the health and function of many

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Fecal Transplantation for C difficile Infection?

Transplantation of feces, via colonoscopy, can cure patients with recurring Clostridium difficile infection (CDI) — even those with the virulent C difficile 027 strain—according to the March issue of Gastroenterology. CDI is a common cause of diarrhea in patients taking antibiotics. Infections have recently become more frequent, severe, refractory to treatment and likely

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